Abstract: A surgical instrument includes a body, a shaft assembly, a stapling head assembly, an anvil, an anvil adjustment assembly, a trigger, and a lockout assembly. The stapling head assembly is operable to drive an annular array of staples. The anvil is configured to couple with the stapling head assembly. The anvil adjustment assembly includes a translating member, which translates relative to the body to thereby adjust the longitudinal position of the anvil relative to the stapling head assembly. The trigger is operable to actuate the stapling head assembly. The lockout assembly includes an electrically powered braking feature. A method of operating the surgical instrument includes providing the lockout assembly in a first state to permit translation of the translating member. The translating member is then translated. The lockout assembly is then transitioned to a second state to prevent further translation of the translating member.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A system and method for operation of an autonomous vehicle (AV) yard truck is provided. A processor facilitates autonomous movement of the AV yard truck, and connection to and disconnection from trailers. A plurality of sensors are interconnected with the processor that sense terrain/objects and assist in automatically connecting/disconnecting trailers. A server, interconnected, wirelessly with the processor, that tracks movement of the truck around and determines locations for trailer connection and disconnection. A door station unlatches/opens rear doors of the trailer when adjacent thereto, securing them in an opened position via clamps, etc. The system computes a height of the trailer, and/or if landing gear of the trailer is on the ground and interoperates with the fifth wheel to change height, and whether docking is safe, allowing a user to take manual control, and optimum charge time(s). Reversing sensors/safety, automated chocking, and intermodal container organization are also provided.

Abstract: An apparatus includes a body, a shaft, a stapling head assembly, and an anvil. The body includes a motor, a first user input feature, and a second user input feature. The first user input feature is operable to activate the motor. The shaft extends distally from the body. The stapling head assembly is positioned at a distal end of the shaft. The stapling head assembly includes an anvil coupling feature, at least one annular array of staples, and a staple driver. The second user input feature is operable to drive the anvil coupling feature longitudinally. The staple driver is operable to drive the at least one annular array of staples. The motor is operable to drive the staple driver. The anvil is configured to couple with the anvil coupling feature. The anvil is further configured to deform the staples driven by the staple driver.

Abstract: A system and method for operation of an autonomous vehicle (AV) yard truck is provided. A processor facilitates autonomous movement of the AV yard truck, and connection to and disconnection from trailers. A plurality of sensors are interconnected with the processor that sense terrain/objects and assist in automatically connecting/disconnecting trailers. A server, interconnected, wirelessly with the processor, that tracks movement of the truck around and determines locations for trailer connection and disconnection. A door station unlatches/opens rear doors of the trailer when adjacent thereto, securing them in an opened position via clamps, etc. The system computes a height of the trailer, and/or if landing gear of the trailer is on the ground and interoperates with the fifth wheel to change height, and whether docking is safe, allowing a user to take manual control, and optimum charge time(s). Reversing sensors/safety, automated chocking, and intermodal container organization are also provided.

Abstract: Methods and systems for reducing electrical leakage current between a patient and a medical device include sensing electrical current in a fluid line and inducing a cancelling electrical current or voltage to reduce the electrical leakage current. A system for implementing the method includes one or more sensors/transducers and a controller that drives the transducer(s) based on signals from the sensor(s).

Abstract: A bone plate can be used to fixate one or more bones. In some examples, a bone plate has first, second, third, and fourth fixation holes. The first and second fixation holes may be located in a distal body region of the bone plate and co-linear with a bridge central longitudinal axis. The third and fourth fixation holes may be located in a proximal body region of the bone plate, with the third fixation hole co-linear with the bridge central longitudinal axis and the fourth fixation hole offset from the bridge central longitudinal axis in a first plane by a first angle and in a second plane by a second angle.

Abstract: A variety of surgical procedures may be performed on the bones of the foot, such as on one or more lesser metatarsals of the foot positioned laterally of the first metatarsal. For example, a surgical procedure may involve cutting an end of one or both of a second metatarsal and an intermediate cuneiform and/or cutting an end of one or both of a third metatarsal and a lateral cuneiform. The tarsometatarsal joints defined be one or both sets of bones may be cut to treat an arthritic joint, metatarsus adductus, and/or other clinical condition. In any case, various surgical instruments can be utilized during a procedure to help increase the accuracy and repeatability of the procedure patient-to-patient, improving overall patient outcomes. For example, one or more cut guides, compressor-distractor devices, and/or other instruments designed to accommodate the specific anatomical conditions of the procedure being performed may be utilized during procedure.

Abstract: A system and method for operation of an autonomous vehicle (AV) yard truck is provided. A processor facilitates autonomous movement of the AV yard truck, and connection to and disconnection from trailers. A plurality of sensors are interconnected with the processor that sense terrain/objects and assist in automatically connecting/disconnecting trailers. A server, interconnected, wirelessly with the processor, that tracks movement of the truck around and determines locations for trailer connection and disconnection. A door station unlatches/opens rear doors of the trailer when adjacent thereto, securing them in an opened position via clamps, etc. The system computes a height of the trailer, and/or if landing gear of the trailer is on the ground and interoperates with the fifth wheel to change height, and whether docking is safe, allowing a user to take manual control, and optimum charge time(s). Reversing sensors/safety, automated chocking, and intermodal container organization are also provided.

Abstract: A performance scanning system that operates to detect and measure surface parameters of a portion of an athlete and uses the surface parameters to determine the likelihood that the athlete's physical performance has been or will be impaired.

Abstract: A sensor/transducer for use in reducing leakage current from a patient fluidly connected to a medical device by tubing filled with a conductive fluid (e.g., blood or dialysate (a “fluid line”)) includes a magnetically conductive core with 1) a centrally located support for a coil of fluid line, and 2) coiled electrical conductors located at positions that are spaced from the centrally located support, on opposite sides of the centrally located support. The sensor/transducer can be used to measure leakage current carried by the conductive fluid in the fluid line, or it can be used to induce current in the fluid line in a manner that reduces the leakage current.

Abstract: A performance scanning system that operates to detect and measure surface parameters of a portion of an athlete and uses the surface parameters to determine the likelihood that the athlete's physical performance has been or will be impaired.

Abstract: The present invention is directed toward a dialysis unit that is modular and portable, with improved functionality. In one embodiment, the dialysis system comprises a top unit that is detachably affixed to a base that comprises a reservoir for fluid storage. Among numerous other features, the portable, modular dialysis system of the present invention has improved power door locking, zoned leak detection, fluid handling, and mechanical design features that enable improved modularity.

Abstract: The present invention is directed toward a dialysis unit that is modular and portable, with improved functionality. In one embodiment, the dialysis system comprises a top unit that is detachably affixed to a base that comprises a reservoir for fluid storage. Among numerous other features, the portable, modular dialysis system of the present invention has improved power door locking, zoned leak detection, fluid handling, and mechanical design features that enable improved modularity.

Abstract: A packaging system and method for receiving articles from a first location, such as a product delivery system, transporting the articles to a second location for unloading the articles such that they are placed in a desired orientation and number of columns, rows, and stacks.

Abstract: The present invention is directed toward a dialysis unit that is modular and portable, with improved functionality. In one embodiment, the dialysis system comprises a top unit that is detachably affixed to a base that comprises a reservoir for fluid storage. Among numerous other features, the portable, modular dialysis system of the present invention has improved power door locking, zoned leak detection, fluid handling, and mechanical design features that enable improved modularity.

Abstract: A packaging system and method for receiving articles from a first location, such as a product delivery system, transporting the articles to a second location for unloading the articles such that they are placed in a desired orientation and number of columns, rows, and stacks.

Abstract: The present invention is directed toward a dialysis unit that is modular and portable, with improved functionality. In one embodiment, the dialysis system comprises a top unit that is detachably affixed to a base that comprises a reservoir for fluid storage. Among numerous other features, the portable, modular dialysis system of the present invention has improved power door locking, zoned leak detection, fluid handling, and mechanical design features that enable improved modularity.

Abstract: A packaging system and method for receiving articles from a first location, such as a product delivery system, transporting the articles to a second location for unloading the articles such that they are placed in a desired orientation and number of columns, rows, and stacks.

Abstract: The subject invention is a scanning system and display and more particularly a scanning system and display for detecting and quantifying similarities or differences between stored data and data collected from a scan. The system operates to perform surface scans and/or deep scans or a combination thereof and utilizes a method or process that decreases the time required for calculating a pose estimate thus increasing its performance thereby making it more practical for many applications that require real-time operations. In a preferred embodiment of the invention the system comprises one or more sensing components for scanning and measuring various surface or internal features of an object and determines differences between data obtained from two or more scans.