Abstract: The provided examples of systems, devices and techniques improve systems and methods for keeping users of automatic drug delivery systems engaged and assisting with the optimal use of the drug delivery system. The automatic drug delivery system may include a drug delivery device and a controller. Through the use of an attrition prevention engine in a cloud-based services system that cooperates with an attrition prevention application executing on the controller of the drug delivery device, notifications that include instructions for adjusting operation of the drug delivery device as well as offer assistance to the patient to optimize performance of the drug delivery system for the patient may be provided. Optimizing the performance of the drug delivery system has been shown to prevent attrition of patients from using the drug delivery system.

Abstract: In a general aspect, junction properties of tunnel junctions are altered by voltage-assisted annealing processes. In some cases, a method includes obtaining a circuit comprising a tunnel junction, modifying a junction resistance of the tunnel junction by applying a voltage across the tunnel junction, and obtaining a measured value of the junction resistance. The tunnel junction may include a metal and a metal oxide.

Abstract: In a general aspect, junction properties of tunnel junctions are altered by voltage-assisted annealing processes. In some cases, a method includes obtaining a circuit comprising a tunnel junction, modifying a junction resistance of the tunnel junction by applying a voltage across the tunnel junction, and obtaining a measured value of the junction resistance. The tunnel junction may include a metal and a metal oxide.

Abstract: In a general aspect, a superconducting quantum processing unit (QPU) includes a cap wafer that has multiple connected circuitry portions. In some cases, a QPU includes first and second substrates. The first substrate includes a first surface, a recess, and first superconducting circuitry. The recess is defined by sidewalls and a recessed surface. The recessed surface resides at a depth in the first substrate. The first superconducting circuitry includes a first circuitry portion on the first surface of the first substrate; a second circuitry portion on the recessed surface of the first substrate; and a connection disposed on at least one of the sidewalls and connecting the first and second circuitry portions. The second substrate includes second superconducting circuitry, which includes a quantum circuit device. The first and second substrates are arranged such that the recess forms an enclosure that houses the quantum circuit device.

Abstract: In a general aspect, a modular quantum processing unit (QPU) includes quantum processor chips inter-connected by a cap structure. In some cases, a modular quantum processing unit includes a tunable-frequency coupler device, a first quantum processor chip, a second quantum processor chip, and a cap structure. The tunable-frequency coupler device includes a superconducting quantum interference device (SQUID) loop, a shunt capacitor, and a flux bias control line that controls a magnetic flux through the SQUID loop. The first quantum processor chip includes a first qubit device, the SQUID loop, the flux bias control line, and a first capacitive coupler device galvanically connected between the first qubit device and the tunable-frequency coupler device. The second quantum processor chip includes a second qubit device.

Abstract: In a general aspect, signals are converted between regimes in a quantum computing system. In some cases, a quantum computing system includes: a quantum processing unit, a control system, a transmission medium, and circuitry. The quantum processing unit includes a superconducting circuit, which includes a plurality of qubit devices. The control system includes a signal generator configured to generate a first control signal and encode qubit control information in the first control signal. The transmission medium is configured to couple the signal generator with a signal conversion system. The signal conversion system is configured to: receive the first control signal generated by the signal generator; and generate a second control signal based on the qubit control information encoded in the first control signal. The circuitry is configured to deliver the second control signal to the plurality of qubit devices.

Abstract: A system including a display output device, a computer including instructions that when executed by the computer, cause the computer to generate a virtual environment, instantiate one or more virtual devices into the virtual environment, instantiate a user representation into the virtual environment, and display the virtual environment, the one or more virtual devices, and the user representation on the display output device, an input device to receive a movement input associated with movement by the user representation in the virtual environment, and the computer further configured with instructions to move or rotate the one or more virtual devices relative to a point of reference in the virtual environment in response to the movement input, while maintaining the user representation stationary.

Abstract: The provided examples of systems, devices and techniques improve systems and methods for keeping users of automatic drug delivery systems engaged and assisting with the optimal use of the drug delivery system. The automatic drug delivery system may include a drug delivery device and a controller. Through the use of an attrition prevention engine in a cloud-based services system that cooperates with an attrition prevention application executing on the controller of the drug delivery device, notifications that include instructions for adjusting operation of the drug delivery device as well as offer assistance to the patient to optimize performance of the drug delivery system for the patient may be provided. Optimizing the performance of the drug delivery system has been shown to prevent attrition of patients from using the drug delivery system.

Abstract: A system including a display output device, a computer including instructions that when executed by the computer, cause the computer to generate a virtual environment, instantiate one or more virtual devices into the virtual environment, instantiate a user representation into the virtual environment, and display the virtual environment, the one or more virtual devices, and the user representation on the display output device, an input device to receive a movement input associated with movement by the user representation in the virtual environment, and the computer further configured with instructions to move or rotate the one or more virtual devices relative to a point of reference in the virtual environment in response to the movement input, while maintaining the user representation stationary.

Abstract: Data visualizations and user interfaces help managers view the totality of deal opportunities in progress and identify potential shortfalls. A deal stage visualization includes deal stage regions corresponding with deal stages and arranged along a first axis. Deal icons represent individual pending deals and are assigned to one of the deal stages. The set of deal icons associated with each deal stage form a deal icon set. The deal stage visualization also includes a second axis representing aggregate values of the deal stages. Each deal icon set is associated with a display region having a displayed size along the second axis that is proportional to an aggregate value of its included deal icons. Different icon sets with different aggregate deal values will have different size scrollable display areas. The size of the display area associated with an icon set remains unchanged during scrolling.

Abstract: Lateral collection architecture for a photodetector is achieved by depositing electrically conducting SLS layers onto a planar substrate and diffusing dopants of a carrier type opposite that of the layers through the layers at selected regions to disorder the superlattice and create diode junctions oriented transversely to the naturally enhanced lateral mobility of photogenerated charge carriers within the superlattice. The diode junctions are terminated at a top surface of the photodetector within an SLS layer of wide bandgap material to minimize unwanted currents. A related architecture disorders the superlattice of topmost SLS layers by diffusing therethrough a dopant configured as a grid and penetrating to a lower SLS layer having the same carrier type as the dopant and opposite that of the topmost layers to isolate pixels within the topmost layers. Ohmic contacts may be deposited on doped regions, pixels, and substrate to provide desired external connections.

Abstract: A waveguide component encapsulation device may include a housing having first and second surfaces, the housing defining a channel extending through the first and second surfaces, a micromachined waveguide component configured to be positioned in the channel, the waveguide component having first and second ends extending outside the channel and beyond the first and second surfaces of the housing by a finite length, and a pair of spacing members configured to align and stabilize the waveguide component within the channel.

Abstract: Lateral collection architecture for a photodetector is achieved by depositing electrically conducting SLS layers onto a planar substrate and diffusing dopants of a carrier type opposite that of the layers through the layers at selected regions to disorder the superlattice and create diode junctions oriented transversely to the naturally enhanced lateral mobility of photogenerated charge carriers within the superlattice. The diode junctions are terminated at a top surface of the photodetector within an SLS layer of wide bandgap material to minimize unwanted currents. A related architecture disorders the superlattice of topmost SLS layers by diffusing therethrough a dopant configured as a grid and penetrating to a lower SLS layer having the same carrier type as the dopant and opposite that of the topmost layers to isolate pixels within the topmost layers. Ohmic contacts may be deposited on doped regions, pixels, and substrate to provide desired external connections.

Abstract: A waveguide component encapsulation device may include a housing having first and second surfaces, the housing defining a channel extending through the first and second surfaces, a micromachined waveguide component configured to be positioned in the channel, the waveguide component having first and second ends extending outside the channel and beyond the first and second surfaces of the housing by a finite length, and a pair of spacing members configured to align and stabilize the waveguide component within the channel.

Abstract: Lateral collection architecture for a photodetector is achieved by depositing electrically conducting SLS layers onto a planar substrate and diffusing dopants of a carrier type opposite that of the layers through the layers at selected regions to disorder the superlattice and create diode junctions oriented transversely to the naturally enhanced lateral mobility of photogenerated charge carriers within the superlattice. The diode junctions are terminated at a top surface of the photodetector within an SLS layer of wide bandgap material to minimize unwanted currents. A related architecture disorders the superlattice of topmost SLS layers by diffusing therethrough a dopant configured as a grid and penetrating to a lower SLS layer having the same carrier type as the dopant and opposite that of the topmost layers to isolate pixels within the topmost layers. Ohmic contacts may be deposited on doped regions, pixels, and substrate to provide desired external connections.

Abstract: Lateral collection architecture for a photodetector is achieved by depositing electrically conducting SLS layers onto a planar substrate and diffusing dopants of a carrier type opposite that of the layers through the layers at selected regions to disorder the superlattice and create diode junctions oriented transversely to the naturally enhanced lateral mobility of photogenerated charge carriers within the superlattice. The diode junctions are terminated at a top surface of the photodetector within an SLS layer of wide bandgap material to minimize unwanted currents. A related architecture disorders the superlattice of topmost SLS layers by diffusing therethrough a dopant configured as a grid and penetrating to a lower SLS layer having the same carrier type as the dopant and opposite that of the topmost layers to isolate pixels within the topmost layers. Ohmic contacts may be deposited on doped regions, pixels, and substrate to provide desired external connections.

Abstract: The instant invention relates to a combination, particularly a synergistic combination, of an alpha-2-delta ligand and an atypical antipsychotic, and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof and their use in the treatment of pain, particularly neuropathic pain.

Abstract: The instant invention relates to a combination of an alpha-2-delta ligand and an AChE inhibitor for use in therapy, particularly in the treatment of pain, particularly neuropathic pain. Particularly preferred alpha-2-delta ligands are gabapentin and pregabalin. Particularly preferred ACHE inhibitors are donepezil (Aricept®), tacrine (cognex®), rivastigmine (Exelon®), physostgmine (Synapton®), galantamine (Reminyl), metrifonate (Promem), neostigmine (Prostigmin) and icopezil.

Abstract: The instant invention relates to a combination, particularly a synergistic combination, of an alpha-2-delta ligand and a dual serotonin-noradrenaline re-uptake inhibitor (DSNRI) or one or both of a selective serotonin re-uptake inhibitor (SSRI) and a selective noradrenaline re-uptake inhibitor (SNRI), and pharmaceutically acceptable salths thereof, pharmaceutical compositions thereof and their use in the treatment of pain, particularly neuropathic pain.