Abstract: A photonic element includes a substrate; a plurality of layers disposed in a stack configuration in a first direction on the substrate; and a first optical transmission component, a second optical transmission component, a third optical transmission component, and a fourth optical transmission component. The first optical transmission component includes two optical transmission structures that are disposed in a first layer, the second optical transmission component includes two optical transmission structures that are disposed in a second layer, the third optical transmission component includes two optical transmission structures that disposed in a third layer, and the fourth optical transmission component includes two optical transmission structures that are disposed in a fourth layer. The second layer and the third layer are each disposed between the first layer and the fourth layer in the stack configuration.

Abstract: The invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Serpina1 gene, and methods of using such RNAi agents to inhibit expression of Serpina1 and methods of treating subjects having a Serpina1 associated disease, such as a liver disorder.

Abstract: Devices, systems, and methods for anchoring a drill rig at a borehole are disclosed. An anchor assembly includes a rod mountable within a borehole, an adapter positioned on an end of the rod, an anchor face unit having a plurality of drill rig assembly mounting features, and an anchor clamp mounted to the anchor face unit. The anchor clamp has a plurality of jaws movable from an engagement position wherein said plurality of jaws are positioned within an adapter groove to a disengagement position wherein said plurality of jaws are positioned away from said adapter groove.

Abstract: Systems and methods for taking, processing, retrieving, and/or displaying images from unmanned aerial vehicles are disclosed, including an unmanned aerial vehicle, comprising: an image capture device; and a controller configured to: determine a flight plan of the unmanned aerial vehicle, the flight plan configured such that the unmanned aerial vehicle and fields of view of the image capture device are restricted to a geographic area within boundaries of a geographic location identified by coordinates of the geographic location; execute the flight plan; and capture, with the image capture device, one or more aerial images restricted to fields of view within the boundaries of the geographic location while executing the flight plan, such that items outside of the boundaries are not captured in the one or more aerial images.

Abstract: Methods for the treatment of condition associated with bromodomain and extraterminal domain (BET) protein activity are disclosed. The methods include administering a therapeutically effective amount of a piperazine BET protein inhibitor or a piperidine BET protein inhibitor to a subject in need thereof. Piperazine BET protein inhibitors, piperidine BET protein inhibitors, and pharmaceutical compositions comprising the BET proteins inhibitors are also described.

Abstract: A spectral imaging system includes an objective lens system, an optical splitter, a dispersion system, and an optical combiner. The optical splitter is arranged to be in an optical path of an object being imaged through the objective lens system to provide an imaging optical path and a spectrometer optical path. The dispersion system is arranged in the spectrometer optical path. The optical combiner is arranged in the imaging optical path and a path of dispersed light from the dispersion system to combined dispersed light with a corresponding optical image of the object.

Abstract: An additive manufacturing apparatus includes a laser and a detection system. The laser emits a laser beam to heat a powder bed to form a melt pool, and the melt pool emits light proportional to a temperature of the melt pool. The detection system includes a spectral disperser and one of a) two or more on-axis sensors or b) a line scanner. The two or more on-axis sensors or the line scanner are/is located along an axis of the emitted light, the detection system receives the emitted light from the melt pool, and an intensity of the emitted light detected by the a) two or more on-axis sensors or the b) line scanner is compared with a blackbody spectral map at a particular wavelength of the emitted light to determine a temperature of the melt pool.

Abstract: Systems and methods for taking, processing, retrieving, and/or displaying images from unmanned aerial vehicles are disclosed, including an unmanned aerial vehicle, comprising: an image capture device; and a controller configured to: determine a flight plan of the unmanned aerial vehicle, the flight plan configured such that the unmanned aerial vehicle and fields of view of the image capture device are restricted to a geographic area within boundaries of a geographic location identified by coordinates of the geographic location; execute the flight plan; and capture, with the image capture device, one or more aerial images restricted to fields of view within the boundaries of the geographic location while executing the flight plan, such that items outside of the boundaries are not captured in the one or more aerial images.

Abstract: A system and method is provided for a cryptographic primitive and authentication protocol comprised of micro-cavity resonators at optical wavelengths. A micro-cavity resonator is illuminated with an optical challenge signal and the cavity returns an output response that is dependent on the input signal. Digital signal processing is performed on the output signal to generate a corresponding digital representation. This process is repeated for variations of the input signal with its digital output being stored in a database. A user or object claiming an identity presents a token to the system. The system selects a subset of the available challenge-response pairs and presents the challenges to the token. The system compares the digitized responses with the original responses expected for that token. The system will approve or deny the claimed identity corresponding to the presented token.

Abstract: A system and method is provided for a cryptographic primitive and authentication protocol comprised of micro-cavity resonators at optical wavelengths. A micro-cavity resonator is illuminated with an optical challenge signal and the cavity returns an output response that is dependent on the input signal. Digital signal processing is performed on the output signal to generate a corresponding digital representation. This process is repeated for variations of the input signal with its digital output being stored in a database. A user or object claiming an identity presents a token to the system. The system selects a subset of the available challenge-response pairs and presents the challenges to the token. The system compares the digitized responses with the original responses expected for that token. The system will approve or deny the claimed identity corresponding to the presented token.

Abstract: A roll-formed steel slat for use in a reciprocating floor slat conveyor system. The roll-formed steel slat is formed in a manner so as to have an upper, load-carrying surface, and a pair of downwardly depending side legs. Each side leg terminates in a foot. One foot is vertically offset from the other to provide a “hold-down” function that prevents the slat from vertically rising as the slat reciprocates back-and-forth.

Abstract: A roll-formed steel slat for use in a reciprocating floor slat conveyor system. The roll-formed steel slat is formed in a manner so as to have an upper, load-carrying surface, and a pair of downwardly depending side legs. Each side leg terminates in a foot. One foot is vertically offset from the other to provide a “hold-down” function that prevents the slat from vertically rising as the slat reciprocates back-and-forth.

Abstract: A roll-formed steel slat for use in a reciprocating floor slat conveyor system. The roll-formed steel slat is formed in a manner so as to have an upper, load-carrying surface, and a pair of downwardly depending side legs. Each side leg terminates in a foot. One foot is vertically offset from the other to provide a “hold-down” function that prevents the slat from vertically rising as the slat reciprocates back-and-forth.

Abstract: A roll-formed steel slat for use in a reciprocating floor slat conveyor system. The roll-formed steel slat is formed in a manner so as to have an upper, load-carrying surface, and a pair of downwardly depending side legs. Each side leg terminates in a foot. One foot is vertically offset from the other to provide a “hold-down” function that prevents the slat from vertically rising as the slat reciprocates back-and-forth.

Abstract: An all-aluminum cross-drive member for a drive unit assembly that is used to reciprocate floor slats back and forth in a conveyor system, The cross-drive member is extruded or milled from a single piece of aluminum, One side of the member carries connecting pieces for linking the member to floor slats, with the member driving the floor slats back and forth as the member is likewise moved lengthwise in back and forth movement, The other side of the member has stiffening ribs that extend lengthwise for giving the member sufficient stiffness to carry loading forces in lieu of the steel cross-drives used in the past.

Abstract: A roll-formed steel slat for use in a reciprocating floor slat conveyor system. The roll-formed steel slat is formed in a manner so as to have an upper, load-carrying surface, and a pair of downwardly depending side legs. Each side leg terminates in a foot. One foot is vertically offset from the other to provide a “hold-down” function that prevents the slat from vertically rising as the slat reciprocates back-and-forth.

Abstract: A roll-formed steel slat for use in a reciprocating floor slat conveyor system. The roll-formed steel slat is formed in a manner so as to have an upper, load-carrying surface, and a pair of downwardly depending side legs. Each side leg terminates in a foot. One foot is vertically offset from the other to provide a “hold-down” function that prevents the slat from vertically rising as the slat reciprocates back-and-forth.

Abstract: A roll-formed steel slat for use in a reciprocating floor slat conveyor system. The roll-formed steel slat is formed in a manner so as to have an upper, load-carrying surface, and a pair of downwardly depending side legs. Each side leg terminates in a foot. One foot is vertically offset from the other to provide a “hold-down” function that prevents the slat from vertically rising as the slat reciprocates back-and-forth.

Abstract: A method comprising receiving aerial images captured by one or more unmanned aerial vehicle; receiving metadata associated with the aerial images captured by the one or more unmanned aerial vehicle; geo-referencing the aerial images based on a geographic location of a surface to determine geographic coordinates of pixels of the aerial images; receiving a geographic location from a user; retrieving one or more of the aerial images associated with the geographic location based on the determined geographic coordinates; and displaying to the user one or more overview image depicting the geographic location and overlaid with one or more icons indicative of and associated with the retrieved aerial images associated with the geographic location.

Abstract: A phase-modulated optical link and methods are provided to suppress distortions in phase-encoded analog photonic links. The phase-modulated optical link includes a distortion compensation element. The distortion compensation element includes an optical comb generator that is seeded by a phase-encoded optical signal. The methods include generating an optical comb seeded by a portion of a phase-encoded optical signal and isolating desired peaks to be combined with a separate portion of the phase-encoded optical signal.