Patents by Inventor Mark Fraley

Mark Fraley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mitotic kinesin inhibitors
    Publication number: 20060105997
    Abstract: The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
    Type: Application
    Filed: June 12, 2003
    Publication date: May 18, 2006
    Inventors: Kenneth Arrington, Paul Coleman, Christopher Cox, Mark Fraley, Robert Garbaccio, George Hartman, William Hoffman, Edward Tasber
  • Mitotic kinesin inhibitors
    Publication number: 20060063942
    Abstract: The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
    Type: Application
    Filed: June 12, 2003
    Publication date: March 23, 2006
    Inventors: Kenneth Arrington, Mark Fraley
  • Mitotic kinesin inhibitors
    Publication number: 20060058327
    Abstract: The present invention relates to tetrahydropyridine compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
    Type: Application
    Filed: December 16, 2003
    Publication date: March 16, 2006
    Inventors: Mark Fraley, Robert Garbaccio
  • Mitotic kinesin inhibitors
    Publication number: 20060052611
    Abstract: The present invention relates to tetrahydropyridine compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin.
    Type: Application
    Filed: December 16, 2003
    Publication date: March 9, 2006
    Inventors: Mark Fraley, Robert Garbaccio, Christy Olson, Edward Tasber
  • Tyrosine kinase inhibitors
    Publication number: 20060025426
    Abstract: The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, macular edema, retinal ischemia, inflammatory diseases, and the like in mammals.
    Type: Application
    Filed: December 5, 2003
    Publication date: February 2, 2006
    Inventor: Mark Fraley
  • Mitotic kinesin inhibitors
    Publication number: 20050228003
    Abstract: The present invention relates to thienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
    Type: Application
    Filed: December 2, 2002
    Publication date: October 13, 2005
    Inventors: Mark Fraley, George Hartman, William Hoffman
  • Mitotic kinesin inhibitors
    Publication number: 20050203110
    Abstract: The present invention relates to azaquinazolinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
    Type: Application
    Filed: May 19, 2003
    Publication date: September 15, 2005
    Inventors: Paul Coleman, Mark Fraley, William Hoffman
  • Tyrosine kinase inhibitors
    Publication number: 20050176753
    Abstract: The present invention relates to imidazopyridine compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
    Type: Application
    Filed: April 28, 2003
    Publication date: August 11, 2005
    Inventors: Mark Bilodeau, Mark Fraley, Zhicai Wu
  • Mitotic kinesin inhibitors
    Publication number: 20050176737
    Abstract: The present invention relates to azolopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
    Type: Application
    Filed: December 2, 2002
    Publication date: August 11, 2005
    Inventors: Mark Fraley, George Hartman, William Hoffman
  • Mitotic kinesin inhibitors
    Publication number: 20050171122
    Abstract: The present invention relates to azolopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
    Type: Application
    Filed: December 2, 2002
    Publication date: August 4, 2005
    Inventors: Mark Fraley, George Hartman, William Hoffman
  • Mitotic kinesin inhibitors
    Publication number: 20050107404
    Abstract: The present invention relates to cycloalkylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
    Type: Application
    Filed: December 2, 2002
    Publication date: May 19, 2005
    Inventors: Mark Fraley, Robert Garbaccio
  • Tyrosine kinase inhibitors
    Publication number: 20050096344
    Abstract: The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
    Type: Application
    Filed: July 28, 2004
    Publication date: May 5, 2005
    Inventors: Mark Fraley, Kenneth Arrington, Mark Bilodeau, George Hartman, William Hoffman, Yuntae Kim, Randall Hungate
  • Tyrosine kinase inhibitors
    Publication number: 20050070546
    Abstract: The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
    Type: Application
    Filed: September 10, 2002
    Publication date: March 31, 2005
    Inventors: Kenneth Arrington, Mark Fraley, Barbara Hanney, Yuntae Kim, Keith Spencer
  • Mitotic kinesin inhibitors
    Publication number: 20050032817
    Abstract: The present invention relates to furanopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
    Type: Application
    Filed: December 2, 2002
    Publication date: February 10, 2005
    Inventors: Mark Fraley, George Hartman