Patents by Inventor Mark Frei

Mark Frei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200375525
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Application
    Filed: August 18, 2020
    Publication date: December 3, 2020
    Applicant: FLINT HILLS SCIENTIFIC, L.L.C.
    Inventors: Ivan Osorio, Mark Frei
  • Publication number: 20190076079
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Application
    Filed: November 13, 2018
    Publication date: March 14, 2019
    Applicant: FLINT HILLS SCIENTIFIC, L.L.C.
    Inventors: IVAN OSORIO, MARK FREI
  • Patent number: 9592003
    Abstract: The system, device, and method may use electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as heart rate. The heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. In yet another embodiment, the system, device, and method may be simply a modified pacemaker having circuitry that determines whether a vagus nerve is being stimulated. In the event that the vagus nerve is being stimulated, the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: March 14, 2017
    Assignee: CYBERONICS, INC.
    Inventors: Ivan Osorio, Mark Frei
  • Publication number: 20150208978
    Abstract: The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as heart rate. The heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. In yet another embodiment, the invention may be simply a modified pacemaker having circuitry that determines whether a vagus nerve is being stimulated. In the event that the vagus nerve is being stimulated, the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.
    Type: Application
    Filed: April 6, 2015
    Publication date: July 30, 2015
    Applicant: FLINT HILLS SCIENTIFIC, L.L.C.
    Inventors: Ivan Osorio, Mark Frei
  • Patent number: 8831732
    Abstract: Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: September 9, 2014
    Assignee: Cyberonics, Inc.
    Inventors: Mark Frei, Ivan Osorio
  • Patent number: 8649871
    Abstract: Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: February 11, 2014
    Assignee: Cyberonics, Inc.
    Inventors: Mark Frei, Ivan Osorio
  • Patent number: 8571643
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: October 29, 2013
    Assignee: Flint Hills Scientific, LLC
    Inventors: Ivan Osorio, Mark Frei
  • Patent number: 8562536
    Abstract: Methods, systems, and apparatus for detecting the seizure in a patient using a medical device. The determination is performed by collecting cardiac data; determining valid heart beats suitable for seizure detection from the cardiac data; calculating heart rate data of interest from the valid heart beats; and identifying a seizure event from the heart rate data. The medical device may then take a responsive action, such as warning, logging the time of the seizure, computing and storing one or more seizure severity indices, and/or treating the seizure.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: October 22, 2013
    Assignee: Flint Hills Scientific, LLC
    Inventors: Ivan Osorio, Mark Frei
  • Publication number: 20120071775
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Application
    Filed: September 20, 2010
    Publication date: March 22, 2012
    Inventors: Ivan Osorio, Mark Frei
  • Publication number: 20120071774
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Application
    Filed: September 16, 2010
    Publication date: March 22, 2012
    Inventors: Ivan Osorio, Mark Frei
  • Publication number: 20110270347
    Abstract: Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test.
    Type: Application
    Filed: April 30, 2010
    Publication date: November 3, 2011
    Inventors: Mark Frei, Ivan Osorio
  • Publication number: 20110270096
    Abstract: Methods, systems, and apparatus for detecting the seizure in a patient using a medical device. The determination is performed by collecting cardiac data; determining valid heart beats suitable for seizure detection from the cardiac data; calculating heart rate data of interest from the valid heart beats; and identifying a seizure event from the heart rate data. The medical device may then take a responsive action, such as warning, logging the time of the seizure, computing and storing one or more seizure severity indices, and/or treating the seizure.
    Type: Application
    Filed: April 29, 2010
    Publication date: November 3, 2011
    Inventors: Ivan Osorio, Mark Frei
  • Publication number: 20110270346
    Abstract: Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test.
    Type: Application
    Filed: April 30, 2010
    Publication date: November 3, 2011
    Inventors: Mark Frei, Ivan Osorio
  • Publication number: 20100198098
    Abstract: A system (10) analyzes signals representative of a subject's brain activity in a signal processor (12) for information indicating the subject's current activity state and for predicting a change in the activity state. One preferred embodiment uses a combination of nonlinear filtering methods to perform real-time analysis of the electro-encephalogram (EEG) or electro-corticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.
    Type: Application
    Filed: December 5, 2009
    Publication date: August 5, 2010
    Inventors: Ivan Osorio, Mark Frei, David Lerner, John Ralston, Josef Dorfmeister
  • Patent number: 7630757
    Abstract: A system (10) analyzes signals representative of a subject's brain activity in a signal processor (12) for information indicating the subject's current activity state and for predicting a change in the activity state. One preferred embodiment uses a combination of nonlinear filtering methods to perform real-time analysis of the electro-encephalogram (EEG) or electro-corticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: December 8, 2009
    Assignee: Flint Hills Scientific LLC
    Inventors: Josef Dorfmeister, Mark Frei, David Lerner, Ivan Osorio, John Ralston
  • Publication number: 20080064934
    Abstract: Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination.
    Type: Application
    Filed: August 13, 2007
    Publication date: March 13, 2008
    Applicant: MEDTRONIC, INC.
    Inventors: Mark Frei, Ivan Osorio, Nina Graves, Scott Schaffner, Mark Rise, Jonathon Giftakis, David Carlson
  • Publication number: 20080033508
    Abstract: Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination.
    Type: Application
    Filed: August 13, 2007
    Publication date: February 7, 2008
    Applicant: MEDTRONIC, INC.
    Inventors: Mark Frei, Ivan Osorio, Nina Graves, Scott Schaffner, Mark Rise, Jonathon Giftakis, David Carlson
  • Publication number: 20070272260
    Abstract: An implantable interface system for a medical device system providing selective interconnectivity between conduits and therapy elements. The interface system contains connecting elements that each provide a robust connection between a selected conduit and a selected therapy element. The interface system enables the use of a surplus of therapy elements so that treatment to the same site (in the case of electrode migration or failure), or to different sites but within the spatial domain of the interface's elements may be delivered through the spare/excess therapy elements without the need for additional major surgical procedures.
    Type: Application
    Filed: April 28, 2006
    Publication date: November 29, 2007
    Inventors: Alexei Nikitin, Ivan Osorio, Mark Frei, Naresh Bhavaraju
  • Publication number: 20070271066
    Abstract: A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, or rank-order filters). Given a raw input signal of arbitrary type, origin, or scale, the present invention enables automated quantification and detection of changes in the distribution of any set of quantifiable features of that signal as they occur in time. Furthermore, the present invention's ability to rapidly and accurately detect changes in certain features of an input signal can also enable prediction in cases where the detected changes associated with an increased likelihood of future signal changes.
    Type: Application
    Filed: March 16, 2007
    Publication date: November 22, 2007
    Inventors: Alexei Nikitin, Mark Frei, Naresh Bhavaraju, Ivan Osorio, Ruslan Davidchack
  • Publication number: 20070249953
    Abstract: Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
    Type: Application
    Filed: December 12, 2006
    Publication date: October 25, 2007
    Applicant: MEDTRONIC, INC.
    Inventors: Mark Frei, Ivan Osorio, David Carlson, Eric Panken, Touby Drew