Abstract: A device for detecting the presence of, or measuring the concentration or amount of, at least one analyte in a sample fluid is disclosed. The device includes at least one electrode; a sample fluid; and a plurality of affinity-based probes capable of binding to the analyte, wherein the affinity-based probes each carry a plurality of redox tags. Further, the detection or measurement of an analyte is caused by analyte binding to the affinity-based probe which further causes a change in electron transfer from the redox tags.

Abstract: Described are sensing devices and methods that continuously sense an analyte included in an interstitial fluid. The device includes at least one ex-vivo sensor specific to the a least one analyte in interstitial fluid. The device further includes at least one sample collection component in the dermis that defines at least in part an advective pathway to transport interstitial fluid to the at least one sensor. The advective pathway is air-tight, and at least one integrated pump applies negative pressure to cause advective transport of interstitial fluid from the dermis, to the sensor, and onto the pump.

Abstract: Described are sensing devices and methods for detecting at least one analyte in a sample solution. The sensor is capable of a pre-storage state, a storage state and a sensing state. The sensor includes at least one substrate-adjacent aptamer; where the sensor, in the absence of a material to reduce or prevent degradation, would incur significant degradation when the sensor is placed in a storage state. The sensor further includes at least one material which reduces or prevents the significant degradation during the storage state.

Abstract: Devices and methods for measuring an analyte. A sensing device 156 includes a sensor and a detection circuit operatively coupled to the sensor. The sensor includes a working electrode having an aptamer and an attached redox couple to electrochemically measure the analyte. The detection circuit is configured to perform a partial scan of the sensor, wherein the partial scan includes only a portion of a full scan. The working electrode may be one of a plurality of working electrodes, and the detection circuit may perform the partial scan on a different subset of the plurality of working electrodes on each of a plurality of measurement cycles. Partial scans may include partial voltage scans, partial current scans, or partial frequency scans.

Abstract: Described are sensing devices and methods that continuously sense at least one analyte in an invasive biofluid are described. The devices include at least one affinity-based sensor with a plurality of probes. The probes include a binding that is specific to the at least one analyte. The device further includes at least one diffusion pathway between the affinity-based sensor and the source of the invasive biofluid.

Abstract: A video signal distribution hub for a video conferencing network in which workstations generate RF video signals. The hub includes a plurality of workstation ports, a plurality of hub ports, a first circuit module and a second circuit module. The first circuit module generates an output signal for each of the workstation ports by combining all of the video signals received over the input lines of all of the workstation ports and all of the hub ports to generate a combined signal. The video signal sent to the workstation port is derived from the combined signal. The second circuit module includes an RF amplifier for each of the hub ports. For each of the hub ports, the second circuit module combines the video signals received over the input lines of all of the workstation ports with the video signals received over the input lines of all of the other hub ports to generate a composite signal that is supplied to the input of the RF amplifier for that hub port.

Abstract: A packaged additive cap adapted for use with containers for parenteral solutions and the like including a continuous side wall, a top, a continuous flange, and a removable backing sheet. The top is integral with the side wall at the upper extremity thereof and the flange is integral with the side wall at the lower extremity thereof. The backing sheet is removably sealed to the underside of the flange to maintain the interior of the cap in sterile condition for use.