Abstract: A system includes a first sensor positioned to sense presence of a contrail in a first volume, wherein the first volume at least partially overlaps an expected volume of a contrail proximate an aircraft. A second sensor is positioned to sense a background reference in a second volume, where the second volume does not overlap the expected volume of a contrail proximate an aircraft. A controller is operatively connected to the first and second sensors. The controller includes machine readable instructions configured to cause the controller to utilize data input from both the first and second volumes to determine if a contrail is present from the aircraft. A system includes machine readable instructions configured to cause the controller to predict persistence of contrails on an intended route through the volume of airspace and to determine an improved route and/or propulsion operation to reduce contrail formation and persistence relative to the intended route.

Abstract: In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. The mutant toxin may include a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to methods and compositions for use in culturing Clostridium difficile and in producing C. difficile toxins.

Abstract: A hybrid photovoltaic-thermal system provides co-generation of electrical energy and thermal energy. Electrical energy is efficiently generated by photovoltaic panels that are cooled by heat exchangers attached thereto, and the cooling of the photovoltaic panels improves the energy output efficiency of the photovoltaic panels. The heat exchangers flow fluid through its channels, and the fluid collects heat from the photovoltaic panels to which the heat exchangers are attached. The heated fluid is then received at and stored in a thermal battery. The thermal battery can be a fluid tank that encourages the fluid to retain the heat collected from the photovoltaic panels. The thermal battery can then supply the heated fluid to thermal loads as thermal energy.

Abstract: The present disclosure provides antibody drug conjugates that bind human cMET, their methods of making, and their uses to treat patients having cancer.

Abstract: The present invention relates to identifying the presence or absence of one or more copy number gains in the ABCB1 gene, the ABCB4 gene or combinations thereof, identifying patients eligible to receive Aurora kinase inhibitor therapy, either as monotherapy or as part of combination therapy, and monitoring patients' response to such therapy.

Abstract: Methods for identifying cancer patients eligible to receive Bcl-2 family inhibitor therapy and for monitoring patient response to Bcl-2 family inhibitor therapy comprise assessment of the expression levels of the biomarker combinations set out in TABLES 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 in a patient tissue sample. The methods of the invention allow more effective identification of patients to receive Bcl-2 family inhibitor therapy and of determination of patient response to the therapy.

Abstract: Methods for identifying cancer patients eligible to receive Bcl-2 family inhibitor therapy and for monitoring patient response to Bcl-2 family inhibitor therapy comprise assessment of the expression levels of the biomarker combinations set out in TABLES 1, 2, 3, 4, 5 or 6 in a patient tissue sample. The methods of the invention allow more effective identification of patients to receive Bcl-2 family inhibitor therapy and of determination of patient response to the therapy.