Patents by Inventor Mark G. Frei

Mark G. Frei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11026622
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: June 8, 2021
    Assignee: FLINT HILLS SCIENTIFIC, L.L.C.
    Inventors: Ivan Osorio, Mark G. Frei
  • Patent number: 10130294
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: November 20, 2018
    Assignee: FLINT HILLS SCIENTIFIC, L.L.C.
    Inventors: Ivan Osorio, Mark G. Frei
  • Patent number: 9974956
    Abstract: Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: May 22, 2018
    Assignee: Cyberonics, Inc.
    Inventors: Mark G Frei, Ivan Osorio
  • Patent number: 9750448
    Abstract: Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: September 5, 2017
    Assignee: CYBERONICS, INC.
    Inventors: Mark G Frei, Ivan Osorio
  • Patent number: 9700256
    Abstract: Methods, systems, and apparatus for detecting the seizure in a patient using a medical device. The determination is performed by collecting cardiac data; determining valid heart beats suitable for seizure detection from the cardiac data; calculating heart rate data of interest from the valid heart beats; and identifying a seizure event from the heart rate data. The medical device may then take a responsive action, such as warning, logging the time of the seizure, computing and storing one or more seizure severity indices, and/or treating the seizure.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: July 11, 2017
    Assignee: Cyberonics, Inc.
    Inventors: Ivan Osorio, Mark G. Frei
  • Patent number: 9659216
    Abstract: A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, or rank-order filters). Given a raw input signal of arbitrary type, origin, or scale, the present invention enables automated quantification and detection of changes in the distribution of any set of quantifiable features of that signal as they occur in time. Furthermore, the present invention's ability to rapidly and accurately detect changes in certain features of an input signal can also enable prediction in cases where the detected changes associated with an increased likelihood of future signal changes.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: May 23, 2017
    Assignee: Flint Hills Scientific, L.L.C.
    Inventors: Alexei V. Nikitin, Mark G. Frei, Naresh C. Bhavaraju, Ivan Osorio, Ruslan L. Davidchack
  • Publication number: 20160375245
    Abstract: Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test.
    Type: Application
    Filed: September 7, 2016
    Publication date: December 29, 2016
    Applicant: CYBERONICS, INC.
    Inventors: Mark G. Frei, Ivan Osorio
  • Publication number: 20160361008
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Application
    Filed: August 24, 2016
    Publication date: December 15, 2016
    Applicant: Flint Hills Scientific, LLC
    Inventors: IVAN OSORIO, Mark G. Frei
  • Patent number: 9468761
    Abstract: Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: October 18, 2016
    Assignee: CYBERONICS, INC.
    Inventors: Mark G Frei, Ivan Osorio
  • Patent number: 9451894
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Grant
    Filed: December 25, 2014
    Date of Patent: September 27, 2016
    Assignee: FLINT HILLS SCIENTIFIC L.L.C.
    Inventors: Ivan Osorio, Mark G. Frei
  • Publication number: 20160213271
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Application
    Filed: January 28, 2016
    Publication date: July 28, 2016
    Applicant: Flint Hills Scientific, L.L.C.
    Inventors: Ivan Osorio, Mark G. Frei
  • Publication number: 20160081610
    Abstract: Methods, systems, and apparatus for detecting the seizure in a patient using a medical device. The determination is performed by collecting cardiac data; determining valid heart beats suitable for seizure detection from the cardiac data; calculating heart rate data of interest from the valid heart beats; and identifying a seizure event from the heart rate data. The medical device may then take a responsive action, such as warning, logging the time of the seizure, computing and storing one or more seizure severity indices, and/or treating the seizure.
    Type: Application
    Filed: December 7, 2015
    Publication date: March 24, 2016
    Applicant: Cyberonics Inc.
    Inventors: IVAN OSORIO, MARK G. FREI
  • Patent number: 9265433
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: February 23, 2016
    Assignee: Flint Hills Scientific, LLC
    Inventors: Ivan Osorio, Mark G. Frei
  • Patent number: 9241647
    Abstract: Methods, systems, and apparatus for detecting the seizure in a patient using a medical device. The determination is performed by collecting cardiac data determining valid heart beats suitable for seizure detection from the cardiac data; calculating heart rate data of interest from the valid heart beats; and identifying a seizure event from the heart rate data. The medical device may then take a responsive action, such as warning, logging the time of the seizure, computing and storing one or more seizure severity indices, and/or treating the seizure.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: January 26, 2016
    Assignee: CYBERONICS, INC.
    Inventors: Ivan Osorio, Mark G. Frei
  • Publication number: 20150223714
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Application
    Filed: March 13, 2015
    Publication date: August 13, 2015
    Applicant: FLINT HILLS SCIENTIFIC, LLC
    Inventors: Ivan Osorio, Mark G. Frei
  • Patent number: 9095314
    Abstract: A failure detection and warning system for monitoring a medical device wherein the system structured to passively or actively detect faults occurring in the medical device being monitored, and wherein the fault includes an unprogrammed and/or undesired shut off of the medical device being monitored or an unprogrammed and/or undesired shut-off of the output of the medical device being monitored by the system.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: August 4, 2015
    Assignee: FLINT HILLS SCIENTIFIC, LLC
    Inventors: Ivan Osorio, Mark G. Frei, Naresh C. Bhavaraju
  • Patent number: 9072832
    Abstract: Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: July 7, 2015
    Assignee: Medtronic, Inc.
    Inventors: Mark G. Frei, Ivan Osorio, Nina M. Graves, Scott F. Schaffner, Mark T. Rise, Jonathon E. Giftakis, David L. Carlson
  • Publication number: 20150173641
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Application
    Filed: December 25, 2014
    Publication date: June 25, 2015
    Inventors: Ivan Osorio, Mark G. Frei
  • Patent number: 9050469
    Abstract: A system and method for analyzing and logging changes in brain state of a subject for administering therapy to the subject based on the at least one cardiac signal wherein the system and method comprises the steps of receiving at least one cardiac signal of the subject into a processor, analyzing the cardiac signal to detect at least one cardiac signal change indicative of a brain state change, and logging at least one characteristic of the detected signal change or the brain state change.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: June 9, 2015
    Assignee: FLINT HILLS SCIENTIFIC, LLC
    Inventors: Ivan Osorio, Mark G. Frei
  • Patent number: 9031655
    Abstract: The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as heart rate. The heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. In yet another embodiment, the invention may be simply a modified pacemaker having circuitry that determines whether a vagus nerve is being stimulated. In the event that the vagus nerve is being stimulated, the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: May 12, 2015
    Assignee: Flint Hills Scientific, LLC
    Inventors: Ivan Osorio, Mark G. Frei