Abstract: Described herein are compositions for delivering fluoride ions and nitric oxide to a subject. The compositions described herein include a poloxamer, an alginate, a nitric oxide releasing compound, fluoride ions, and calcium ions. In one aspect, the compositions are hydrogels. The compositions described herein can eradicate oral pathogens and prevent demineralization of teeth in a subject.

Abstract: Described herein are methods for controlling the release of nitric oxide from a nitric oxide releasing material. The method involves exposing the nitric oxide releasing material to light having a discrete wavelength, wherein the nitric oxide releasing material comprises a (i) a polysiloxane network and (ii) a plurality of nitric oxide-donating moieties covalently bonded to the polysiloxane network. The tunability of nitric oxide release from the nitric oxide releasing materials described herein provides unique therapeutic profiles that correspond to endogenous thresholds of nitric oxide for desired physiological response. The methods described herein can prevent bacterial growth as well as the formation of biofilms and fibrinogen on articles such as, for example, medical devices.