Patents by Inventor Mark Gartner

Mark Gartner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10456227
    Abstract: A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: October 29, 2019
    Assignee: ENSION INC.
    Inventors: Ali Hussain, Linda Cahalan, Greg Johnson, Mark Gartner, Patrick Cahalan, Brian J Fill, Jeffrey W. Speakman
  • Publication number: 20190125946
    Abstract: A highly portable advanced adult and pediatric compact ECLS system is based around an integrated pump-oxygenator. The system includes a central a blood inlet and flow path extending along a general longitudinal axis of the system; a pump housing defining a pump inlet in fluid communication with the central blood flow path; an impeller rotationally received within the area of the pump inlet, wherein the impeller is magnetically supported and magnetically driven; an array of hollow fiber membranes configured for gas transfer within the system for oxygenation of blood flowing across the hollow fiber membranes, wherein the membranes include a covalently-bonded heparin-based bioactive surface, and wherein the blood flow path extends from the impeller to a position to flow perpendicular over the array of hollow fiber membranes; and a blood outlet configured to receive blood flowing past the array of hollow fiber membranes.
    Type: Application
    Filed: December 14, 2018
    Publication date: May 2, 2019
    Inventors: Mark Gartner, Minkyun Noh, David L. Trumper
  • Publication number: 20180125620
    Abstract: A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.
    Type: Application
    Filed: July 3, 2017
    Publication date: May 10, 2018
    Inventors: Ali Hussain, Linda Cahalan, Greg Johnson, Mark Gartner, Patrick Cahalan, Brian J. Fill, Jeffrey W. Speakman
  • Patent number: 9693841
    Abstract: A variety of medical devices including staples sutures and dental floss with surface treatment on at least one tissue-facing surface to improve biologic function such as to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm2, and ii) a thrombin deactivation of at least 0.2 IU/cm2; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 4, 2017
    Assignee: ENSION, INC.
    Inventors: Ali Hussain, Linda Cahalan, Greg Johnson, Mark Gartner, Patrick Cahalan, Brian J Fill, Jeffrey W. Speakman
  • Publication number: 20140288592
    Abstract: A variety of medical devices including staples sutures and dental floss with surface treatment on at least one tissue-facing surface to improve biologic function such as to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm2, and ii) a thrombin deactivation of at least 0.2 IU/cm2; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Applicant: ENSION, INC.
    Inventors: Ali HUSSAIN, Linda Cahalan, Greg Johnson, Mark Gartner, Patrick Cahalan, Brian J. Fill, Jeffrey W. Speakman
  • Publication number: 20130110137
    Abstract: A variety of polymeric synthetic hernia mesh prosthesis with surface treatment on at least one tissue-facing surface to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm2, and ii) a thrombin deactivation of at least 0.2 IU/cm2; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment. The synthetic hernia mesh may be formed of monofilament or multifilament polypropylene or polyester, and may be formed as a multi-layer prosthesis with an outer layer formed of a polymeric synthetic hernia mesh with surface treatment to control tissue adhesion coupled to one or more polymeric synthetic hernia meshes without such surface treatments.
    Type: Application
    Filed: October 1, 2012
    Publication date: May 2, 2013
    Applicant: Ension, Inc.
    Inventors: Enrico Nicolo, Linda Cahalan, Greg Johnson, Mark Gartner, Patrick Cahalan, Brian J Fill, Ali HUSSAIN, Jeffrey W. Speakman
  • Patent number: 8343567
    Abstract: A method of treating the surface of a medical device with a biomolecule comprising the steps of: providing a polyolefin substrate forming a medical device; cleaning the polyolefin substrate; exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy to yield a plasma-deposited polyacrylic acid coating on the polyolefin substrate; and attaching a biomolecule, such as heparin, to the polyolefin substrate following formation of the plasma-deposited polyacrylic acid coating on the polyolefin substrate.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: January 1, 2013
    Assignee: Ension, Inc.
    Inventors: Patrick Cahalan, Linda Cahalan, Greg Johnson, Mark Gartner
  • Publication number: 20120107901
    Abstract: A method of treating the surface of a medical device with a biomolecule comprising the steps of: providing a polyolefin substrate forming a medical device; cleaning the polyolefin substrate; exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy to yield a plasma-deposited polyacrylic acid coating on the polyolefin substrate; and attaching a biomolecule, such as heparin, to the polyolefin substrate following formation of the plasma-deposited polyacrylic acid coating on the polyolefin substrate.
    Type: Application
    Filed: January 9, 2012
    Publication date: May 3, 2012
    Applicant: Ension, Inc.
    Inventors: Patrick Cahalan, Linda Cahalan, Greg Johnson, Mark Gartner
  • Patent number: 8114465
    Abstract: Processes are provided for preparing a substrate coated with a biomolecule, comprising: a) providing a substrate; b) coating the substrate with a polysiloxane, typically by exposing the substrate to a reactive gas containing siloxane functional groups and to plasma energy to yield a plasma-deposited polysiloxane surface on the substrate; c) rendering the polysiloxane surface amino functional; and d) contacting the amino-functional polysiloxane surface with a biomolecule under conditions effective to attach the biomolecule to the substrate. The coated substrate may be a medical device that demonstrates an ability to maintain gas permeability when in contact with blood or blood components, compared to a substantially identical medical device that has not been coated with a biomolecule using this process.
    Type: Grant
    Filed: April 2, 2008
    Date of Patent: February 14, 2012
    Assignee: Ension, Inc.
    Inventors: Patrick Cahalan, Linda Cahalan, Greg Johnson, Mark Gartner
  • Publication number: 20080241349
    Abstract: Processes are provided for preparing a substrate coated with a biomolecule, comprising: a) providing a substrate; b) coating the substrate with a polysiloxane, typically by exposing the substrate to a reactive gas containing siloxane functional groups and to plasma energy to yield a plasma-deposited polysiloxane surface on the substrate; c) rendering the polysiloxane surface amino functional; and d) contacting the amino-functional polysiloxane surface with a biomolecule under conditions effective to attach the biomolecule to the substrate. The coated substrate may be a medical device that demonstrates an ability to maintain gas permeability when in contact with blood or blood components, compared to a substantially identical medical device that has not been coated with a biomolecule using this process.
    Type: Application
    Filed: April 2, 2008
    Publication date: October 2, 2008
    Applicant: Ension, Inc.
    Inventors: Patrick Cahalan, Linda Cahalan, Greg Johnson, Mark Gartner
  • Publication number: 20070027456
    Abstract: The integrated medical apparatus includes an operator handle end and a multi-prong grasping member positioned within and movable relative to a grasper lumen that extends from the handle end, wherein the grasping prongs are moved between an open and closed position by relative axial movement between the prongs of the grasping member and the grasper lumen. The medical apparatus includes a contractible snare and a plurality of axially moveable snare pushing arms. At least two of the snare pushing arms include a snare holding and release mechanism, wherein the snare pushing arms are configured to advance the snare in an open, encircling position to a final deployed position where the snare can be released through the activation of the holding and release mechanism of the pushing arms, and finally tightened in a conventional fashion, such as pulling on an end of the snare at the handle end.
    Type: Application
    Filed: July 18, 2006
    Publication date: February 1, 2007
    Applicant: ENSION, INC.
    Inventors: Mark Gartner, Brian Fill
  • Publication number: 20050056080
    Abstract: A method and apparatus for measuring blood gas concentrations and partial pressures, in real time, using a pneumatic detector to indicate partial pressure variations in the blood gas.
    Type: Application
    Filed: August 2, 2004
    Publication date: March 17, 2005
    Inventors: Christopher Lucci, Mark Gartner
  • Publication number: 20050042131
    Abstract: An apparatus and method related to mass transfer and fluid pump devices. The apparatus generally includes a housing that defines an interior cavity, a diffuser positioned in the interior cavity of the housing, the diffuser comprising porous elements arranged in discrete layers, a diffusion area that is defined by a pre-determined distance between the discrete layers of porous elements. A fluid is accelerated through each diffuser layer and is then de-accelerated in the diffusion area.
    Type: Application
    Filed: August 16, 2004
    Publication date: February 24, 2005
    Inventor: Mark Gartner
  • Patent number: 6348175
    Abstract: A blood membrane oxygenator having a housing defining a blood flow path, a rotor hub in the form of a double lumen shaft, and a plurality of distributor disks each having a plurality of hollow fibers which extend across the housing blood flow path. The plurality of distributor disks rotate within the housing to mix the blood resulting in three-dimensional mixing, disruption of the blood boundary layer and efficient blood oxygenation.
    Type: Grant
    Filed: October 5, 1999
    Date of Patent: February 19, 2002
    Assignee: University of Pittsburgh
    Inventors: Harvey S. Borovetz, Philip Litwak, Mark Gartner, Gary D. Reeder, Patricia Sawzik
  • Patent number: 6106776
    Abstract: A blood membrane oxygenator has a housing defining a blood flow path, a rotor hub in the form of a double lumen shaft, and a plurality of distributor disks each having a plurality of hollow fibers which extend across the housing blood flow path. The plurality of distributor disks rotate within the housing to mix the blood resulting in three-dimensional mixing, disruption of the blood boundary layer and efficient blood oxygenation.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: August 22, 2000
    Assignee: University of Pittsburgh
    Inventors: Harvey S. Borovetz, Philip Litwak, Mark Gartner, Gary D. Reeder, Patricia Sawzik