Patents by Inventor Mark Geng

Mark Geng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREPARATION OF HIGHLY CONCENTRATED MRNA
    Publication number: 20250340586
    Abstract: Provided herein are compositions of highly concentrated mRNA and related methods for preparation and use of the compositions as mRNA process intermediates in the synthesis of therapeutic and prophylactic mRNA formulations.
    Type: Application
    Filed: May 16, 2023
    Publication date: November 6, 2025
    Applicant: ModernaTX, Inc.
    Inventors: Mark Geng, James Sinoimeri
  • CONTINUOUS PRECIPITATION FOR MRNA PURIFICATION
    Publication number: 20250136970
    Abstract: Aspects of the disclosure relate to methods of purifying mRNA by precipitating the mRNA, washing the precipitate to remove impurities and salts, and resuspending the washed mRNA to produce an mRNA composition. The disclosure describes reagents and methods useful for precipitation, washing, and resuspension of mRNA, and compositions produced by the methods described herein.
    Type: Application
    Filed: February 3, 2023
    Publication date: May 1, 2025
    Applicant: ModernaTX, inc.
    Inventor: Mark Geng
  • MULTICOLUMN CHROMATOGRAPHY MRNA PURIFICATION
    Publication number: 20240368580
    Abstract: Described herein are methods of purifying nucleic acids (e.g., mRNAs) from feed solutions using continuous, multicolumn chromatography approaches. Also described are methods of increasing the efficiency of chromatography methods by performing purification methods in parallel using multiple columns.
    Type: Application
    Filed: August 12, 2022
    Publication date: November 7, 2024
    Applicant: ModernaTX, inc.
    Inventors: Mark Geng, Jason Murphy, Lei ZHOU, James Sinoimeri, Tahir Kapoor, Joseph Elich