Patents by Inventor Mark George TEESE

Mark George TEESE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Surface display of functional proteins in a broad range of gram negative bacteria
    Patent number: 10683509
    Abstract: The present invention relates to a method for the surface display of a recombinant polypeptide on the surface of a host cell, said method comprising the steps: (a) providing a host cell transformed with a nucleic acid fusion operatively linked with an expression control sequence, said nucleic acid fusion comprising: (i) a portion encoding a signal peptide, (ii) a portion encoding the recombinant polypeptide to be displayed, (iii) a portion encoding a transmembrane linker, and (iv) a portion encoding the trans porter domain of an EhaA protein, and (b) culturing the host cell under conditions wherein the nucleic acid fusion is expressed and the expression product comprising the recombinant polypeptide is displayed on the surface of the host cell.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: June 16, 2020
    Assignee: Autodisplay Biotech GmbH
    Inventors: Joachim Jose, Mark George Teese, Shanna Sichwart, Iasson Tozakidis
  • IMPROVED SURFACE DISPLAY OF FUNCTIONAL PROTEINS IN A BROAD RANGE OF GRAM NEGATIVE BACTERIA
    Publication number: 20160108407
    Abstract: The present invention relates to a method for the surface display of a recombinant polypeptide on the surface of a host cell, said method comprising the steps: (a) providing a host cell transformed with a nucleic acid fusion operatively linked with an expression control sequence, said nucleic acid fusion comprising: (i) a portion encoding a signal peptide, (ii) a portion encoding the recombinant polypeptide to be displayed, (iii) a portion encoding a transmembrane linker, and (iv) a portion encoding the trans porter domain of an EhaA protein, and (b) culturing the host cell under conditions wherein the nucleic acid fusion is expressed and the expression product comprising the recombinant polypeptide is displayed on the surface of the host cell.
    Type: Application
    Filed: June 4, 2014
    Publication date: April 21, 2016
    Applicant: AUTODISPLAY BIOTECH GMBH
    Inventors: Joachim JOSE, Mark George TEESE, Shanna SICHWART, Iasson TOZAKIDIS