Abstract: The present invention provides a method of design based process control optimization. In an embodiment, the method of design based process control optimization includes creating a circuit layout database including a design rule set. At least one algorithm is employed to query the circuit layout database to calculate at least one process specification limit. The method includes comparing the calculated at least one process specification limit with at least one predefined technology process tool capability to determine if the calculated at least one process specification limit allows for a manufacturable process. If the calculated at least one process specification limit does not allow for the manufacturable process, the limit may be re-optimized.