Patents by Inventor Mark Graham

Mark Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060043244
    Abstract: An equipment support, such as an IV pole, comprises an upper portion, a lower portion having a lower end configured to engage a socket, and an actuator movable relative to the lower end. When the upper portion is gripped by a releasable gripper, the lower end can be disengaged from the socket by moving the actuator from a first position to a second position. The lower portion can be telescoped relative to the upper portion by moving the actuator from the second position to a third position.
    Type: Application
    Filed: April 8, 2005
    Publication date: March 2, 2006
    Inventors: Mark Graham, Steven Schwartz
  • Publication number: 20060031989
    Abstract: A patient support includes a lower frame, an upper frame supported above the lower frame, an equipment carrier coupled to the upper frame, and an actuator operable to adjust the orientation of the equipment carrier to compensate for the upper frame changing its orientation between the Trendelenberg and reverse Trendelenberg positions.
    Type: Application
    Filed: July 20, 2005
    Publication date: February 16, 2006
    Inventors: Mark Graham, Stephen Holl, David Newkirk, Jonathan Turner, Christian Reinke, Stephen Hamberg
  • Publication number: 20060024727
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
    Type: Application
    Filed: August 25, 2005
    Publication date: February 2, 2006
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Rosanne Crooke, Mark Graham
  • Publication number: 20060019920
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.
    Type: Application
    Filed: July 11, 2005
    Publication date: January 26, 2006
    Inventors: C. Bennett, Susan Freier, Brett Monia, Nicholas Dean, Hong Zhang, Robert McKay, Donna Ward, William Gaarde, Jacqueline Wyatt, Andrew Watt, Rosanne Crooke, Mark Graham, Pamela Nero, Kenneth Dobie, Alexander Borchers, Eric Marcusson, Mark Roach
  • Publication number: 20060009410
    Abstract: Methods are provided for modulating the expression of genes involved in lipid metabolism, useful in the treatment of conditions associated with cardiovascular risk. Antisense oligonucleotides targeted to apolipoprotein B reduce the level of apolipoprotein B mRNA, lower serum cholesterol and shift liver gene expression profiles from those of an obese animal towards those of a lean animal. Further provided are methods for improving the cardiovascular risk of a subject through antisense inhibition of apolipoprotein B. Also provided are methods for employing antisense oligonucleotides targeted to apolipoprotein B to modulate a cellular pathway or metabolic process.
    Type: Application
    Filed: May 5, 2005
    Publication date: January 12, 2006
    Inventors: Rosanne Crooke, Mark Graham
  • Publication number: 20050287558
    Abstract: Compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for diagnosis and treatment of diseases and conditions associated with expression of apolipoprotein B are provided.
    Type: Application
    Filed: May 5, 2005
    Publication date: December 29, 2005
    Inventors: Rosanne Crooke, Mark Graham, Steven Mah
  • Publication number: 20050227938
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.
    Type: Application
    Filed: December 17, 2004
    Publication date: October 13, 2005
    Inventors: C. Bennett, Brenda Baker, Nicholas Dean, Brett Monia, Susan Freier, James Karras, Hong Zhang, Susan Murray, Madeline Butler, Erich Koller, Thomas Condon, William Gaarde, Andrew Watt, Mark Graham, Jacqueline Wyatt, Lex Cowsert, Kenneth Dobie, Mark Roach
  • Publication number: 20050222073
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding thyroid hormone receptor interactor 6. Methods of using these compounds for modulation of thyroid hormone receptor interactor 6 expression and for treatment of diseases associated with expression of thyroid hormone receptor interactor 6 are provided.
    Type: Application
    Filed: March 2, 2005
    Publication date: October 6, 2005
    Inventors: C. Bennett, Brett Monia, Rosanne Crooke, Mark Graham, Susan Freier, Pamela Nero, Edward Wancewicz, Nicholas Dean, Lex Cowsert, Kenneth Dobie
  • Publication number: 20050181376
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of microsomal triglyceride transfer protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding microsomal triglyceride transfer protein. Methods of using these compounds for modulation of microsomal triglyceride transfer protein expression and for treatment of diseases associated with expression of microsomal triglyceride transfer protein are provided.
    Type: Application
    Filed: January 16, 2004
    Publication date: August 18, 2005
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Rosanne Crooke, Mark Graham
  • Publication number: 20050153924
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Interferon gamma receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interferon gamma receptor 2. Methods of using these compounds for modulation of Interferon gamma receptor 2 expression and for treatment of diseases associated with expression of Interferon gamma receptor 2 are provided.
    Type: Application
    Filed: December 15, 2004
    Publication date: July 14, 2005
    Inventors: C. Bennett, Brett Monia, Susan Murray, Madeline Butler, Nicholas Dean, Rosanne Crooke, Mark Graham, Hong Zhang, Susan Freier, Brenda Baker, Eric Marcusson, Jacqueline Wyatt, Lex Cowsert, Kenneth Dobie, Andrew Watt
  • Publication number: 20050137160
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of cholesteryl ester transfer protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding cholesteryl ester transfer protein. Methods of using these compounds for modulation of cholesteryl ester transfer protein expression and for treatment of diseases associated with expression of cholesteryl ester transfer protein are provided.
    Type: Application
    Filed: January 7, 2005
    Publication date: June 23, 2005
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Rosanne Crooke, Mark Graham, Pamela Nero, Edward Wancewicz
  • Publication number: 20050065104
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of acyl coenzyme A cholesterol acyltransferase-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl coenzyme A cholesterol acyltransferase-1. Methods of using these compounds for modulation of acyl coenzyme A cholesterol acyltransferase-1 expression and for treatment of diseases associated with expression of acyl coenzyme A cholesterol acyltransferase-1 are provided.
    Type: Application
    Filed: July 17, 2002
    Publication date: March 24, 2005
    Inventors: Rosanne Crooke, Mark Graham, Kristina Tarbet
  • Publication number: 20050043256
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.
    Type: Application
    Filed: July 15, 2003
    Publication date: February 24, 2005
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne Crooke, Mark Graham
  • Patent number: 6848215
    Abstract: An assembly includes a first, second and third components having respective first, second and third holes. The assembly further includes a locating feature assembled into the holes having a small portion and a large portion that provide a shoulder therebetween. The locating feature further includes a fixing portion near the small portion to secure the second component relative to the assembly and a fixing portion near the large portion to secure the third component relative to the assembly. The small portion is located in the second hole to align the locating feature relative to the second component, and the large portion is located in the third hole to align the locating feature relative to the third component. The second component is aligned relative to the third component, and the first component is situated between the second and third components and between the shoulder and the second component.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: February 1, 2005
    Assignee: Meritor Light Vehicle Systems - France
    Inventors: Mark Graham Lawrie, Yann Le Gallo, Pascal De Vries, Klaus B. Wilhelm Blume, Charles Berry Hopson, Herve Laurandel, Simon Blair Dobson, Damien Cabanne
  • Publication number: 20050014257
    Abstract: Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for diagnosis and treatment of disease associated with expression of C-reactive protein are provided.
    Type: Application
    Filed: June 1, 2004
    Publication date: January 20, 2005
    Inventors: Rosanne Crooke, Mark Graham
  • Publication number: 20050009088
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
    Type: Application
    Filed: August 17, 2004
    Publication date: January 13, 2005
    Applicant: ISIS PHARMACEUTICALS, INC.
    Inventors: Rosanne Crooke, Mark Graham, Kristina Tarbet, Kenneth Dobie
  • Publication number: 20050000019
    Abstract: An equipment management system provides an equipment support for supporting patient care equipment. The equipment support may be mountable on an arm that extends from a wall, on a column depending from the arm, on a wall mount, on a stand, or on a patient support. Various methods may be used to vertically move the equipment support up and down to engage and disengage the equipment support from supporting devices.
    Type: Application
    Filed: March 17, 2004
    Publication date: January 6, 2005
    Inventors: David Newkirk, Mark Graham, Steven Schwartz, Michael Cerimele, John Ruehl
  • Publication number: 20040250240
    Abstract: Repetitive synchronization in program code is optimized through lock coarsening that is performed subject to a number of constraints. Using a forward pass over the program code followed by a backward pass, region extent bits may be determined that identify the points in the program where object locking can be coarsened. The program code may then be modified to realize coarsened locking regions determined based on the region extent bits. Alternatively, previously determined value numbers may provide much of the information collected by the two passes. In such a case, a single pass over the program code may locate features that limit lock coarsening opportunities. A set of synchronization operations that can be removed may then be determined and used when modifying the program code to coarsen locking regions.
    Type: Application
    Filed: May 27, 2004
    Publication date: December 9, 2004
    Applicant: International Business Machines Corporation
    Inventors: Mark Graham Stoodley, Vijay Sundaresan
  • Publication number: 20040243792
    Abstract: In preparing inlined program code for compiling, a synchronization depth is recorded in a table for ranges of program counter addresses. Furthermore, a stack frame is dedicated for the recordation of references to objects locked during the execution of the code. Such references are recorded in the stack frame at a location based on synchronization depth. When an exception occurs, the synchronization depth may be determined from the table and used to obtain, from the stack frame, a reference to an object from which a lock should be removed.
    Type: Application
    Filed: December 9, 2003
    Publication date: December 2, 2004
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventor: Mark-Graham Stoodley
  • Patent number: 6818718
    Abstract: Method of separating molecules by providing a cross-linked polymer gel having a cross-linking moiety of the formula wherein X, X′, Y, Z and R2 are as defined in the specification. A sample containing the molecules to be separated is placed on the gel, and the gel is subjected to a separation technique.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: November 16, 2004
    Assignee: The University of Melbourne
    Inventors: David Henry Solomon, Grace Chan, Peter Agapitus Kambouris, Mark Graham Looney