Abstract: A system and method for communicating with a device over an external transmission medium. The system may include a host computer system, including a user application, a serial bus interface driver, and a first portion of an interface driver. The host computer may include a serial bus host controller. A serial bus may couple the serial bus host controller to a serial bus interface, which may include an interface connector adapted to couple to the device, wherein the serial bus interface may be operable to store and execute a second portion of the interface driver. When the user application generates an API function call, the first portion of the interface driver may generate a frame of interface commands that are transferred to the second portion of the interface driver for execution, thereby causing signals to be transmitted over an interface bus to the device.