Patents by Inventor Mark Gustavson
Mark Gustavson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220292156Abstract: An optimized artificial intelligence search system may comprise a pinch zoomable 3D representation of an outline providing content in response to search queries. Search results may include a emoticon system using emotions to sentiment to further describe search results. A user interface may comprise means and methods of allowing a user to delete search results and then be presented with queries to indicate why the deleted results were not relevant to the user. Disclosed systems may further comprise a computing device configured to allow a user to input search queries into a content extraction module that is in communication with an optimized search engine; an optimized search engine configured to receive search queries from the content extraction module and execute search queries to generate or render a list of search results to the content extraction module.Type: ApplicationFiled: May 25, 2022Publication date: September 15, 2022Inventors: Mark Gustavson, Garnet R. Chaney
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Patent number: 11347817Abstract: An optimized artificial intelligence search system for providing content in response to search queries, comprising: a computing device configured to allow a user to input search queries into a content extraction module that is in communication with an optimized search engine; an optimized search engine configured to receive search queries from the content extraction module and execute search queries to generate or render a list of search results to the content extraction module, and a database comprising templates associated with topics and the optimized search engine configured to interact with the database to choose templates in response to search queries, the content extraction module configured to highlight relevant content of web pages from the list of search results and display highlighted relevant content of web pages from the list of search results by filtering out irrelevant content on the computing device.Type: GrantFiled: January 21, 2020Date of Patent: May 31, 2022Inventors: Mark Gustavson, Garnet R. Chaney
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Publication number: 20200159798Abstract: An optimized artificial intelligence search system for providing content in response to search queries, comprising: a computing device configured to allow a user to input search queries into a content extraction module that is in communication with an optimized search engine; an optimized search engine configured to receive search queries from the content extraction module and execute search queries to generate or render a list of search results to the content extraction module, and a database comprising templates associated with topics and the optimized search engine configured to interact with the database to choose templates in response to search queries, the content extraction module configured to highlight relevant content of web pages from the list of search results and display highlighted relevant content of web pages from the list of search results by filtering out irrelevant content on the computing device.Type: ApplicationFiled: January 21, 2020Publication date: May 21, 2020Inventors: Mark Gustavson, Garnet R. Chaney, Jonathan Fried
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Patent number: 9240043Abstract: A method is described for the reproducible quantification of biomarker expression, including biomarker expression in a tissue sample. Methods and systems are described whereby reproducible scores for biomarker expression are obtained independent of instrument, its location, or operator.Type: GrantFiled: September 15, 2009Date of Patent: January 19, 2016Assignee: NOVARTIS AGInventors: Jason Christiansen, Robert Pinard, Mark Gustavson, Brian Bourke, Gregory R. Tedeschi, Dylan M. Reilly, Maciej P. Zerkowski, Christine Williams, Dongxiao Wang
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Patent number: 8878983Abstract: The invention relates to a system for automatically adjusting an exposure time to improve or otherwise optimize a dynamic range of a digital image. The system includes a camera configured to capture an image of a subject within the field of view at a first exposure time. The captured image is composed of multiple pixels, with each pixel having a respective intensity value. The system further includes a shutter or suitable control configured to control an exposure time of the camera. A controller configured to carryout the following steps including: (a) querying a frequency distribution of pixel intensity values; (b) determining an effective “center of mass” of such a distribution, or histogram, to determine an adjusted exposure time; and (c) capturing a second image of the subject at the adjusted exposure time thereby obtaining an image with an improved or optimal dynamic range.Type: GrantFiled: May 27, 2011Date of Patent: November 4, 2014Assignee: HistoRx, Inc.Inventors: Jason Christiansen, Dylan M. Reilly, Brian Bourke-Martin, Mark Gustavson
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Patent number: 8655037Abstract: The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator intervention or decision making. The method provides for precise definition of tissue, cellular or subcellular compartments particularly in histological tissue sections in which to quantitatively analyzing protein expression.Type: GrantFiled: December 14, 2012Date of Patent: February 18, 2014Assignee: HistoRx, Inc.Inventors: Jason H. Christiansen, Robert Pinard, Mark Gustavson, Brian Bourke, Dylan M. Reilly, Gregory R. Tedeschi
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Publication number: 20130344510Abstract: Disclosed herein are methods of identifying suitable patients for postoperative radiotherapy based on the discovery that the quantification of ER, beyond simple positive/negative characterization, can provide valuable predictive information for the treatment of cancer, specifically breast cancer, and more particularly may predict a group more likely to respond to RT and spare patients from a potentially harmful treatment. Furthermore, the true quantification of ER expression provides a continuous recurrence risk assessment for patients being treated with tamoxifen, and therefore the standardization of the data across sites and imaging platforms significantly reduces the misclassification of patients when compared to the current standard by which ER expression is determined.Type: ApplicationFiled: December 2, 2011Publication date: December 26, 2013Applicants: UTI Limited Partnership, HistoRx, Inc.Inventors: Mark Gustavson, Jason Christiansen, Anthony Martin Magliocco
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Patent number: 8605971Abstract: A system and method for automatically and quantitatively determining the optimal dilution of a reagent is provided. In one embodiment, a plurality of dilution sets are received, where each of the dilution sets consist of a different respective dilution value and a respective plurality of immunoassay staining intensity values. A respective dynamic range metric is determining for each of the plurality of dilution sets relative to the respective plurality immunoassay staining intensity values. Having found the respective dynamic range metric, a dilution set having the numerically optimal dynamic range metric is selected and the dilution value of that dilution set is selected as being representative of an optimal dilution level of the reagent for use in a quantitative immunoassay. In one embodiment, a system is provided with a microscope, an image sensor, and processor module configured determine an optimal dilution of a reagent for use in an quantitative immunoassay.Type: GrantFiled: February 3, 2012Date of Patent: December 10, 2013Assignee: HistoRx, Inc.Inventors: Robert Pinard, Gregory R. Tedeschi, Mark Gustavson
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Patent number: 8497080Abstract: The method of the invention pertains to determining signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.Type: GrantFiled: February 5, 2013Date of Patent: July 30, 2013Assignees: HistoRx, Inc., Yale UniversityInventors: Mark Gustavson, Jennifer Giltnane, Marisa P. Dolled-Filhart, Robert L. Camp, David L. Rimm
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Patent number: 8367351Abstract: The method of the invention pertains to determining the signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.Type: GrantFiled: May 7, 2007Date of Patent: February 5, 2013Assignees: Historx, Inc., Yale UniversityInventors: Mark Gustavson, Jennifer Giltnane, Marisa P. Dolled-Filhart, Robert L. Camp, David L. Rimm
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Patent number: 8335360Abstract: The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator intervention or decision making. The method provides for precise definition of tissue, cellular or subcellular compartments particularly in histological tissue sections in which to quantitatively analyzing protein expression.Type: GrantFiled: May 14, 2008Date of Patent: December 18, 2012Assignee: Historx, Inc.Inventors: Jason H. Christiansen, Robert Pinard, Mark Gustavson, Brian Bourke, Dylan M. Reilly, Gregory R. Tedeschi
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Publication number: 20120270233Abstract: The present method relates to quantification of prognostic and predictive biomarkers of the PDK/AKT/mTOR pathway, such as GSK3?, S6, CREB, PTEN, AKT and mTOR, using AQUA® analysis to estimate both patient risk and benefit of treatment to patients diagnosed with glioblastoma. Unlike traditional IHC, the AQUA® system is objective and produces quantitative in situ protein expression data on a continuous scale. Taking advantage of the power of the AQUA system, the present method provides a highly robust and standardized diagnostic assays that can be used in the clinical setting to provide physicians with reliable prognostic and predictive information. Glioblastoma multiform (GBM) remains one of the most aggressive human cancers, and biomarkers that provide prognostic and predictive information would be extremely valuable to both the physician and the patient. A patient's risk may be determined using the prognostic biomarkers of the present method.Type: ApplicationFiled: February 10, 2009Publication date: October 25, 2012Inventors: Donald E. Waldron, Alpana Waldron, Robert Pinard, Mark Gustavson
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Publication number: 20120201435Abstract: A system and method for automatically and quantitatively determining the optimal dilution of a reagent is provided. In one embodiment, a plurality of dilution sets are received, where each of the dilution sets consist of a different respective dilution value and a respective plurality of immunoassay staining intensity values. A respective dynamic range metric is determining for each of the plurality of dilution sets relative to the respective plurality immunoassay staining intensity values. Having found the respective dynamic range metric, a dilution set having the numerically optimal dynamic range metric is selected and the dilution value of that dilution set is selected as being representative of an optimal dilution level of the reagent for use in a quantitative immunoassay. In one embodiment, a system is provided with a microscope, an image sensor, and processor module configured determine an optimal dilution of a reagent for use in an quantitative immunoassay.Type: ApplicationFiled: February 3, 2012Publication date: August 9, 2012Inventors: Robert PINARD, Gregory R. TEDESCHI, Mark GUSTAVSON
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Patent number: 8121365Abstract: A system and method for automatically and quantitatively determining the optimal dilution of a reagent is provided. In one embodiment of the claimed method, a plurality of dilution sets are received, where each of the dilution sets consist of a different respective dilution value and a respective plurality of immunoassay staining intensity values. A respective dynamic range metric is determining for each of the plurality of dilution sets relative to the respective plurality immunoassay staining intensity values. Having found the respective dynamic range metric, a dilution set having the numerically optimal dynamic range metric is selected and the dilution value of that dilution set is selected as being representative of an optimal dilution level of the reagent for use in a quantitative immunoassay. In one embodiment, a system is provided with a microscope, an image sensor, and processor module configured determine an optimal dilution of a reagent for use in an quantitative immunoassay.Type: GrantFiled: August 7, 2008Date of Patent: February 21, 2012Assignee: HistoRx, Inc.Inventors: Robert Pinard, Gregory R. Tedeschi, Mark Gustavson
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Publication number: 20110228993Abstract: The invention relates to a system for automatically adjusting an exposure time to improve or otherwise optimize a dynamic range of a digital image. The system includes a camera configured to capture an image of a subject within the field of view at a first exposure time. The captured image is composed of multiple pixels, with each pixel having a respective intensity value. The system further includes a shutter or suitable control configured to control an exposure time of the camera. A controller configured to carryout the following steps including: (a) querying a frequency distribution of pixel intensity values; (b) determining an effective “center of mass” of such a distribution, or histogram, to determine an adjusted exposure time; and (c) capturing a second image of the subject at the adjusted exposure time thereby obtaining an image with an improved or optimal dynamic range.Type: ApplicationFiled: May 27, 2011Publication date: September 22, 2011Inventors: Dylan M. Reilly, Brian Bourke-Martin, Mark Gustavson, Jason Christiansen
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Patent number: 7978258Abstract: The invention relates to a system for automatically adjusting an exposure time to improve or otherwise optimize a dynamic range of a digital image. The system includes a camera configured to capture an image of a subject within the field of view at a first exposure time. The captured image is composed of multiple pixels, with each pixel having a respective intensity value. The system further includes a shutter or suitable control configured to control an exposure time of the camera. A controller configured to carryout the following steps including: (a) querying a frequency distribution of pixel intensity values; (b) determining an effective “center of mass” of such a distribution, or histogram, to determine an adjusted exposure time; and (c) capturing a second image of the subject at the adjusted exposure time thereby obtaining an image with an improved or optimal dynamic range.Type: GrantFiled: August 29, 2008Date of Patent: July 12, 2011Assignee: HistoRx, Inc.Inventors: Jason Christiansen, Dylan M. Reilly, Brian Bourke-Martin, Mark Gustavson
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Publication number: 20110081665Abstract: This invention provides a method of making a prognosis for a patient afflicted with a type of cancer such as colon cancer, based upon quantification of biomarkers such as thymidylate synthase in subcellular compartments.Type: ApplicationFiled: March 10, 2010Publication date: April 7, 2011Inventors: David L. Rimm, Gregory Tedeschi, Robert L. Camp, Mark Gustavson
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Publication number: 20100136549Abstract: A method is described for the reproducible quantification of biomarker expression, including biomarker expression in a tissue sample. Methods and systems are described whereby reproducible scores for biomarker expression are obtained independent of instrument, its location, or operator.Type: ApplicationFiled: September 15, 2009Publication date: June 3, 2010Inventors: Jason Christiansen, Robert Pinard, Mark Gustavson, Brian Bourke, Gregory R. Tedeschi, Dylan M. Reilly, Maciej P. Zerkowski, Christine (Jones) Williams, Dongxiao Wang
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Patent number: 7709222Abstract: This invention provides a method of making a prognosis for a patient afflicted with a type of cancer such as colon cancer, based upon quantification of biomarkers such as thymidylate synthase in subcellular compartments.Type: GrantFiled: July 13, 2007Date of Patent: May 4, 2010Assignees: Yale University, Historx, Inc.Inventors: David L. Rimm, Gregory Tedeschi, Robert L. Camp, Mark Gustavson
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Publication number: 20100081666Abstract: Methods of cancer diagnosis and prognosis using biomarkers.Type: ApplicationFiled: July 14, 2009Publication date: April 1, 2010Applicant: WyethInventors: Christina M. COUGHLIN, Michael E. BURCZYNSKI, Marisa P. DOLLED-FILHART, Robert PINARD, Donald WALDROM, Charles ZACHARCHUK, Frederick IMMERMANN, Maha KARNOUB, Jason CHRISTIANSEN, Mark GUSTAVSON, Annette MOLINARO, Alpana Waldron