Abstract: A portable cooler includes storage compartments for separately storing items in the cooler. A first compartment is generally formed at least partly by walls of the cooler. A second compartment is formed at least partly within the first compartment such that the second compartment extends at least partly into the first compartment. The second compartment is formed by at least one wall that also forms part of the first compartment. Items in the first and second compartments may be stored separately from each other and are accessible through separate openings in the cooler. In addition, the second compartment may be sealed from the first compartment so as to inhibit the ingress of liquid into the second compartment from the first compartment.