Patents by Inventor Mark H. Skolnick
Mark H. Skolnick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7447643Abstract: A decision-support system for providing a clinician with real-time patient data specific to each patient that the clinician is to examine in a defined time period. The system including a decision-support module that is configured to generate decision-supported patient data that is specific to each patient that a clinician is to examine in a defined time period. The decision-support module including an inference engine that communicates with a knowledge module and a patient module to generate the decision-supported patient data. In real-time communication with the decision-support module is a user module that is adapted to present the decision-supported patient data in real-time to the clinician in a configuration that assists the clinician in treating each patient. The user module further allowing the clinician to changes elements of the decision-supported patient data and receive new recommendations and medical care suggestions in real-time from the decision-support module.Type: GrantFiled: September 21, 2000Date of Patent: November 4, 2008Assignee: Theradoc.com, Inc.Inventors: Jonathan B. Olson, Mark H. Skolnick, Stanley L. Pestotnik, William F. Harty, III, Richard J. Boekweg, Bo Lu, Merle A. Sande
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Patent number: 7213009Abstract: Disclosed is a method for delivering decision-supported patient data to a clinician to aid the clinician with the diagnosis and treatment of a medical condition. The method including presenting a patient with questions generated by a decision-support module and gathering patient data indicative of the responses to the questions. Each question presented to the patient is based upon the prior questions presented to and the patient data gathered from the patient. Upon receiving the patient data from the client module, evaluating the patient data at the module to generate decision-supported patient data, this supported patient data includes medical condition diagnoses, pertinent medical parameters for the medical condition, and medical care recommendations for the medical condition. At the client module or a clinician's client module, presenting the clinician with this patient data in either a standardized format associated with a progress note or a format selected by the clinician.Type: GrantFiled: September 9, 2003Date of Patent: May 1, 2007Assignee: Theradoc, Inc.Inventors: Stanley L. Pestotnik, Jonathan B. Olson, Matthew H. Samore, R. Scott Evans, Barry M. Stults, Michael A. Rubin, William H. Tettelbach, William F. Harty, III, Richard J. Boekweg, Bo Lu, David D. Eardley, Michael E. Baza, Mark H. Skolnick, Merle A. Sande
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Publication number: 20040260666Abstract: Disclosed is a method for delivering decision-supported patient data to a clinician to aid the clinician with the diagnosis and treatment of a medical condition. The method including presenting a patient with questions generated by a decision-support module and gathering patient data indicative of the responses to the questions. Each question presented to the patient is based upon the prior questions presented to and the patient data gathered from the patient. Upon receiving the patient data from the client module, evaluating the patient data at the module to generate decision-supported patient data, this supported patient data includes medical condition diagnoses, pertinent medical parameters for the medical condition, and medical care recommendations for the medical condition. At the client module or a clinician's client module, presenting the clinician with this patient data in either a standardized format associated with a progress note or a format selected by the clinician.Type: ApplicationFiled: September 9, 2003Publication date: December 23, 2004Inventors: Stanley L. Pestotnik, Jonathan B. Olson, Matthew H. Samore, R. Scott Evans, Barry M. Stults, Michael A. Rubin, William H. Tettelbach, William F. Harty, Richard J. Boekweg, Bo Lu, David D. Eardley, Michael E. Baza, Mark H. Skolnick, Merle A. Sande
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Patent number: 6162897Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA1 gene, including gene therapy, protein replacement therapy and protein mimetics.Type: GrantFiled: May 2, 1997Date of Patent: December 19, 2000Assignees: Myriad Genetics, Inc., University of Utah Research Foundation, The United States of America as represented by the Department of Health and Human ServicesInventors: Mark H. Skolnick, David E. Goldgar, Yoshio Miki, Jeff Swenson, Alexander Kamb, Keith D. Harshman, Donna M. Shattuck-Eidens, Sean V. Tavtigian, Roger W. Wiseman, P. Andrew Futreal
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Patent number: 5989815Abstract: The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.Type: GrantFiled: April 29, 1997Date of Patent: November 23, 1999Assignees: University of Utah Research Foundation, Myriad Genetics, Inc.Inventors: Mark H. Skolnick, Lisa A. Cannon-Albright, Alexander Kamb
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Patent number: 5989885Abstract: The present invention relates to mutations in the MKK4 gene in human cancers and their use in the diagnosis and prognosis of human cancer. Specific mutations in the MKK4 gene which are associated with breast, pancreatic, colorectal and testicular cancers have been identified. The invention also relates to the therapy of human cancers which have a mutation in the MKK4 gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.Type: GrantFiled: June 13, 1997Date of Patent: November 23, 1999Assignee: Myriad Genetics, Inc.Inventors: David H. -F. Teng, Sean V. Tavtigian, William L. Perry, III, Mark H. Skolnick
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Patent number: 5753441Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA1 gene, including gene therapy, protein replacement therapy and protein mimetics.Type: GrantFiled: January 5, 1996Date of Patent: May 19, 1998Assignees: Myriad Genetics, Inc., University of Utah Research Foundation, The United States of America as represented by the Department of Health and Human ServicesInventors: Mark H. Skolnick, David E. Goldgar, Yoshio Miki, Jeff Swenson, Alexander Kamb, Keith D. Harshman, Donna M. Shattuck-Eidens, Sean V. Tavtigian, Roger W. Wiseman, P. Andrew Futreal
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Patent number: 5747282Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA1 gene, including gene therapy, protein replacement therapy and protein mimetics.Type: GrantFiled: June 7, 1995Date of Patent: May 5, 1998Assignees: Myraid Genetics, Inc., University of Utah Research Foundation, The United States of America as represented by the Secretary of Health and Human ServicesInventors: Mark H. Skolnick, David E. Goldgar, Yoshio Miki, Jeff Swenson, Alexander Kamb, Keith D. Harshman, Donna M. Shattuck-Eidens, Sean V. Tavtigian, Roger W. Wiseman, P. Andrew Futreal
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Patent number: 5710001Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. Additionally, the invention relates to somatic mutations in the BRCA1 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA1 gene, including gene therapy, protein replacement therapy and protein mimetics.Type: GrantFiled: June 7, 1995Date of Patent: January 20, 1998Assignees: Myriad Genetics, Inc., University of Utah Research Foundation, The United States of America as represented by the Secretary of Health and Human Services, Technology Transfer OfficeInventors: Mark H. Skolnick, David E. Goldgar, Yoshio Miki, Jeff Swenson, Alexander Kamb, Keith D. Harshman, Donna M. Shattuck-Eidens, Sean V. Tavtigian, Roger W. Wiseman, P. Andrew Futreal
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Patent number: 5624819Abstract: The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.Type: GrantFiled: June 7, 1995Date of Patent: April 29, 1997Assignees: University of Utah Research Foundation, Myriad Genetics, Inc.Inventors: Mark H. Skolnick, Lisa A. Cannon-Albright, Alexander Kamb