Patents by Inventor Mark H. Updike

Mark H. Updike has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4421854
    Abstract: L-leucine is prepared by cultivation of an analogue-resistant mutant of Arthrobacter citreus in an aqueous nutrient medium under aerobic conditions. The cultivation is preferably carried out at about 30.degree. C. and at a pH of 5 to 0.8. L-leucine is recovered from the fermentation broth. In a preferred embodiment the mutant is further mutated, and the second mutant is similarly fermented to prepare L-leucine.
    Type: Grant
    Filed: June 16, 1982
    Date of Patent: December 20, 1983
    Assignee: W. R. Grace & Co.
    Inventors: Mark H. Updike, Gary J. Calton
  • Patent number: 4421853
    Abstract: L-leucine is prepared by cultivation of an analogue-resistant mutant of Brevibacterium thiogenitalis in an aqueous nutrient medium under aerobic conditions. The cultivation is preferably carried out at about 30.degree. C. and at a pH of 5 to 8. L-leucine is recovered from the fermentation broth.
    Type: Grant
    Filed: June 16, 1982
    Date of Patent: December 20, 1983
    Assignee: W. R. Grace & Co.
    Inventors: Mark H. Updike, Gary J. Calton
  • Patent number: 4329427
    Abstract: L-isoleucine is prepared by cultivation of an analogue-resistant mutant of Brevibacterium thiogenitalis in an aqueous nutrient medium under aerobic conditions in the presence of from 0.001 to 15 w/v percent of a post-threonine precursor for L-isoleucine. The cultivation is preferably carried out at about 30.degree. C. and at a pH of 5 to 9. L-isoleucine is recovered from the fermentation broth.
    Type: Grant
    Filed: October 6, 1980
    Date of Patent: May 11, 1982
    Assignee: W. R. Grace & Co.
    Inventors: Mark H. Updike, Gary J. Calton