Abstract: Optical transmission microcatheter devices and methods of endovascular embolization are described herein. There is provided a microcatheter device comprising a working lumen and a mechanically protected waveguide. The working lumen has at least one outlet port at a distal end of the working lumen and is configured to provide intravascular injection of a Photoactivated Embolic Agent (PEA) to a target vessel via the at least one outlet port. The mechanically protected waveguide (MPW) is operably connected to the working lumen and is configured to emit at least one electromagnetic wave via the at least one outlet port for delivery to the target vessel.

Abstract: Systems and methods are provided for forming an optical element within a transparent material using an irradiating optical beam, where the irradiating optical beam is employed to induce internal refractive index changes in the transparent substrate. Optical elements such as bulk and gradient index lenses may be formed in the transparent structure according various embodiments of the disclosure. An optical element may be formed by selecting a refractive index profile for the optical element, determining a corresponding suitable spatially dependent irradiation intensity profile for producing the selected refractive index profile, focusing an irradiating optical beam within the transparent structure, and controlling an intensity and position of the focused irradiating optical beam within the transparent structure according to the spatially dependent irradiation intensity profile.

Abstract: Systems and methods are provided for forming an optical element within a transparent material using an irradiating optical beam, where the irradiating optical beam is employed to induce internal refractive index changes in the transparent substrate. Optical elements such as bulk and gradient index lenses may be formed in the transparent structure according various embodiments of the disclosure. An optical element may be formed by selecting a refractive index profile for the optical element, determining a corresponding suitable spatially dependent irradiation intensity profile for producing the selected refractive index profile, focusing an irradiating optical beam within the transparent structure, and controlling an intensity and position of the focused irradiating optical beam within the transparent structure according to the spatially dependent irradiation intensity profile.