Patents by Inventor Mark Hegarty
Mark Hegarty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230341323Abstract: A sample support apparatus (150) for use in a spectrometer (285), comprises an elongate support (110) comprising a plurality of receiving portions (112) each configured to receive a respective internal reflection element (IRE) or IRE slide (135), the elongate support having a sample side and a beam side opposite the sample side; and a plurality of IREs or IRE slides (135), each IRE or IRE slide provided at a respective receiving portion (112) of the elongate support (110), wherein each IRE or IRE slide (135) has at least one sample-receiving portion provided on a sample side thereof, and at least one beam-receiving portion provided on a beam side thereof. The sample support apparatus (150) has a stowed configuration, and a deployed configuration configured to allow application of a sample (276) on one or more of the plurality of IREs or IRE slides (135).Type: ApplicationFiled: October 15, 2021Publication date: October 26, 2023Inventors: Matthew J. Baker, Mark Hegarty, Holly Jean Butler
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Patent number: 11668646Abstract: A sample slide (100) for use in a spectrometer (501), wherein the sample slide comprises a plurality of sample-receiving portions (111-114) provided on a sample side (115) of the slide, and a plurality of beam-receiving portions (121-124) provided on a beam-receiving side (125) of the slide, each beam-receiving portion being arranged opposite a respective sample-receiving portion, and wherein each beam-receiving portion is configured to act as an internal reflection element (IRE). A device (300) for use with a spectrometer (501) comprises a stage (330) configured to receive a sample slide (100); and a moving mechanism (360) configured to move the sample slide relative to a sample-measuring location (320) of the device. Associated methods for preparing a sample and measuring a sample are also disclosed.Type: GrantFiled: December 1, 2021Date of Patent: June 6, 2023Assignee: DXCOVER LIMITEDInventors: Matthew J. Baker, Mark Hegarty, Holly Jean Butler, David Palmer
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Publication number: 20230068250Abstract: A method of detection of a status of cells within a cell culture is described. The method is based on comparing an IR spectrum of a test sample obtained from the cell culture with an IR spectrum of a control sample or samples or with an IR spectrum of a sample or samples obtained at an earlier time point in the cell culture and correlating differences between the spectra with the status of the cells. The status may be classified into healthy or unhealthy. The test sample may or may not contain cells. The test sample may contain cell fragments, cell components or cell media, or may be cell supernatant. The comparison may be performed using a predictive model based on pattern recognition algorithms, such as support vector machines SVM, linear discriminant analysis LDA, principal component discriminant function analysis PC-DFA, neural networks, or random forests). The analysis results may be used to monitor and/or control the cell culturing process.Type: ApplicationFiled: January 15, 2021Publication date: March 2, 2023Inventors: Mark Hegarty, Matthew J. Baker, Holly Butler
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Publication number: 20220091023Abstract: A sample slide (100) for use in a spectrometer (501), wherein the sample slide comprises a plurality of sample-receiving portions (111-114) provided on a sample side (115) of the slide, and a plurality of beam-receiving portions (121-124) provided on a beam-receiving side (125) of the slide, each beam-receiving portion being arranged opposite a respective sample-receiving portion, and wherein each beam-receiving portion is configured to act as an internal reflection element (IRE). A device (300) for use with a spectrometer (501) comprises a stage (330) configured to receive a sample slide (100); and a moving mechanism (360) configured to move the sample slide relative to a sample-measuring location (320) of the device. Associated methods for preparing a sample and measuring a sample are also disclosed.Type: ApplicationFiled: December 1, 2021Publication date: March 24, 2022Inventors: Matthew Baker, Mark Hegarty, Holly Jean Butler, David Paimer
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Patent number: 11215553Abstract: A sample slide (100) for use in a spectrometer (501), wherein the sample slide comprises a plurality of sample-receiving portions (111-114) provided on a sample side (115) of the slide, and a plurality of beam-receiving portions (121-124) provided on a beam-receiving side (125) of the slide, each beam-receiving portion being arranged opposite a respective sample-receiving portion, and wherein each beam-receiving portion is configured to act as an internal reflection element (IRE). A device (300) for use with a spectrometer (501) comprises a stage (330) configured to receive a sample slide (100); and a moving mechanism (360) configured to move the sample slide relative to a sample-measuring location (320) of the device. Associated methods for preparing a sample and measuring a sample are also disclosed.Type: GrantFiled: March 28, 2018Date of Patent: January 4, 2022Assignee: DXCOVER LIMITEDInventors: Matthew J. Baker, Mark Hegarty, Holly Jean Butler, David Palmer
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Publication number: 20210339245Abstract: A sample container (100) for use in a ATR-FTIR spectrometer, comprises an internal reflection element “IRE” (101), the IRE comprising a first surface (104) and a second surface (105). The first surface (104) is configured to receive a sample (20) and the second surface (105) is an infrared beam-receiving surface. The IRE (101) forms at least a portion of a wall of the sample container (100), such that in use, when a sample (20) is provided on the first surface (104) of the IRE (101), the sample (20) is provided within the sample container (100).Type: ApplicationFiled: October 11, 2019Publication date: November 4, 2021Inventors: Matthew Baker, Mark Hegarty, Holly Jean Butler
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Publication number: 20200056987Abstract: A sample slide (100) for use in a spectrometer (501), wherein the sample slide comprises a plurality of sample-receiving portions (111-114) provided on a sample side (115) of the slide, and a plurality of beam-receiving portions (121-124) provided on a beam-receiving side (125) of the slide, each beam-receiving portion being arranged opposite a respective sample-receiving portion, and wherein each beam-receiving portion is configured to act as an internal reflection element (IRE). A device (300) for use with a spectrometer (501) comprises a stage (330) configured to receive a sample slide (100); and a moving mechanism (360) configured to move the sample slide relative to a sample-measuring location (320) of the device. Associated methods for preparing a sample and measuring a sample are also disclosed.Type: ApplicationFiled: March 28, 2018Publication date: February 20, 2020Inventors: Matthew J. Baker, Mark Hegarty, Holly Jean Buttler, David Palmer
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Patent number: 5770224Abstract: A controlled release capsule comprises a male plug (2) formed of a water swellable hydrogel which is engaged within a neck portion (4) of a female body (6). The capsule contains a pharmaceutically active material. In contact with an aqueous medium, such as in the gastrointestinal tract, the hydrogel plug swells and becomes disengaged from the body, thereby releasing the active material. In order to facilitate insertion of the male plug into the neck of the body, the body has a flared mouth portion (14) which is wider than the neck. The neck itself may be wider or narrower than the remainder of the body. A water-soluble cap (8) has detentes (18) which clip over the flared mouth portion so as to lock the cap thereto.Type: GrantFiled: June 26, 1995Date of Patent: June 23, 1998Assignee: R. P. Scherer CorporationInventors: Abdul Rashid, Howard Norman Ernest Stevens, Massoud Bakhshaee, James Robertson Miller Kelso, Mark Hegarty, James Leonard Mackie