Patents by Inventor Mark Hellberg

Mark Hellberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
    Publication number: 20110257137
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Application
    Filed: March 10, 2011
    Publication date: October 20, 2011
    Applicant: KALYPSYS, INC.
    Inventors: Allen Borchardt, Robert Davis, Clay Beauregard, Daniel Becker, Daniel Gamache, Stewart A. Noble, Mark Hellberg, Peter Klimko, Zhihai Qiu, Joseph Payne, John Yanni
  • HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
    Publication number: 20110237599
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Application
    Filed: March 9, 2011
    Publication date: September 29, 2011
    Applicant: Kalypsys, Inc.
    Inventors: Allen Borchardt, Robert Davis, Clay Beauregard, Daniel Gamache, Mark Hellberg, Peter Klimko, John Yanni
  • AMINOPYRAZINE ANALOGS FOR TREATING GLAUCOMA AND OTHER RHO KINASE-MEDIATED DISEASES AND CONDITIONS
    Publication number: 20080269249
    Abstract: Methods for using aminopyrazine analogs to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of aminopyrazine analogs, are also disclosed.
    Type: Application
    Filed: December 14, 2005
    Publication date: October 30, 2008
    Applicant: ALCON, INC.
    Inventors: Mark Hellberg, Andrew Rusinko, Alan Henderson, Cheng Guo, Mark Hadden, Helene Decornez
  • (INDAZOL-5-YL)-PYRAZINES AND (1,3-DIHYDRO-INDOL-2-ONE)-PYRAZINES FOR TREATING RHO KINASE-MEDIATED DISEASES AND CONDITIONS
    Publication number: 20070149548
    Abstract: Methods for using (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines, are disclosed herein.
    Type: Application
    Filed: December 19, 2006
    Publication date: June 28, 2007
    Applicant: ALCON MANUFACTURING, LTD.
    Inventors: Mark Hellberg, Najam Sharif, Jesse May, Andrew Rusinko, Hwang-Hsing Chen
  • CONTROL OF INTRAOCULAR PRESSURE USING ALK5 MODULATION AGENTS
    Publication number: 20070142376
    Abstract: An ophthalmic pharmaceutical composition useful in the treatment of glaucoma and control of intraocular pressure comprising an effective amount of a selective modulator of ALK5 receptor activity is disclosed. Also disclosed is a method of treating glaucoma and controlling intraocular pressure comprising applying a therapeutically effective amount of a pharmaceutical composition comprising a selective modulator of ALK5 receptor activity to an affected eye of a patient.
    Type: Application
    Filed: December 15, 2006
    Publication date: June 21, 2007
    Applicant: ALCON, INC.
    Inventors: Debra FLEENOR, Iok-Hou PANG, Allan SHEPARD, Mark HELLBERG, Abbot CLARK, Peter KLIMKO
  • Phenylethylamine analogs and their use for treating glaucoma
    Publication number: 20070072920
    Abstract: Phenylethylamine analogs useful for treating glaucoma are disclosed.
    Type: Application
    Filed: September 22, 2006
    Publication date: March 29, 2007
    Inventors: Mark Hellberg, Abdelmoula Namil, Zixia Feng, Jennifer Ward
  • Method of reducing intraocular pressure and treating glaucoma
    Publication number: 20060154981
    Abstract: The use of 5,6,7-trihydroxyheptanoic acid and analogs for the treatment of ocular hypertension and glaucoma is disclosed.
    Type: Application
    Filed: January 12, 2006
    Publication date: July 13, 2006
    Inventors: Peter Klimko, Mark Hellberg, Wan-Heng Wang, Abbot Clark, Loretta McNatt
  • Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases and conditions
    Publication number: 20060142307
    Abstract: Methods for using aminopyrazine analogs to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of aminopyrazine analogs, are also disclosed.
    Type: Application
    Filed: December 14, 2005
    Publication date: June 29, 2006
    Inventors: Mark Hellberg, Andrew Rusinko
  • Agents which regulate, inhibit, or modulate the activity and/or expression of lysyl oxidase (LOX) and LOX-like proteases as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies
    Publication number: 20060134172
    Abstract: The present invention provides a method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof by administering a therapeutically effective amount of at least one non-nucleotide or non-protein agent that inhibits expression and/or signaling of lysyl oxidase (LOX) or a lysyl oxidase-like protease (LOXL).
    Type: Application
    Filed: December 5, 2005
    Publication date: June 22, 2006
    Inventors: Allan Shepard, Abbot Clark, Mark Hellberg
  • Method of treating dry eye disorders using 13(S)-HODE and its analogs
    Publication number: 20060128803
    Abstract: The topical use of 13(S)-HODE and analogs are disclosed for the treatment of dry eye disorders.
    Type: Application
    Filed: December 14, 2005
    Publication date: June 15, 2006
    Inventors: Peter Klimko, Daniel Gamache, Gustav Graff, Mark Hellberg, John Falck, John Yanni
  • Beta-hydroxyphenylalkylamines and their use for treating glaucoma
    Publication number: 20060106106
    Abstract: ?-hydroxyphenylalkylamines and their use for lowering and controlling ocular hypertension and treating glaucoma are disclosed.
    Type: Application
    Filed: September 22, 2003
    Publication date: May 18, 2006
    Inventors: Richard Glennon, Mark Hellberg
  • 5,6,7-Trihydroxyheptanoic acid and analogs for the treatment of ocular diseases and diseases associated with hyperproliferative and angiogenic responses
    Publication number: 20060099248
    Abstract: Compositions containing 5,6,7-trihydroxyheptanoic acid and analogs and their use for treating posterior segment ocular diseases and diseases characterized by cellular hyperproliferation or angiogenesis, are disclosed.
    Type: Application
    Filed: November 8, 2005
    Publication date: May 11, 2006
    Inventors: Peter Klimko, Mark Hellberg, David Bingaman, Daniel Gamache
  • Superoxide dismutase mimics for the treatment of ocular disorders and diseases
    Publication number: 20060089343
    Abstract: The use of SOD mimics, particularly Mn(III) porphyrin complexes, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Application
    Filed: December 5, 2003
    Publication date: April 27, 2006
    Inventors: Peter Klimko, Robert Collier, Mark Hellberg
  • Neurophilin ligands for treating ocular conditions
    Publication number: 20060083774
    Abstract: The use of neurophilin ligands for treating glaucoma and lowering IOP is disclosed.
    Type: Application
    Filed: December 6, 2005
    Publication date: April 20, 2006
    Inventors: Iok-Hou Pang, Mark Hellberg, Abdelmoula Namil
  • Method of treating dry eye disorders and uveitis
    Publication number: 20060058375
    Abstract: The topical use of 5,6,7-trihydroxyheptanoic acid and analogs are disclosed for the treatment of dry eye disorders and uveitis.
    Type: Application
    Filed: November 7, 2005
    Publication date: March 16, 2006
    Inventors: Peter Klimko, Mark Hellberg, Daniel Gamache
  • Superoxide dismutase mimics for the treatment of ocular disorders and diseases
    Publication number: 20060035880
    Abstract: The use of SOD mimics, particularly Mn(III) salen SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Application
    Filed: December 5, 2003
    Publication date: February 16, 2006
    Inventors: Peter Klimko, Robert Collier, Mark Hellberg
  • Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
    Publication number: 20060009503
    Abstract: The present invention provides benzodifuran imidazoline derivatives and benzofuran imidazoline derivatives for lowering intraocular pressure and providing ocular neuroprotection.
    Type: Application
    Filed: December 9, 2002
    Publication date: January 12, 2006
    Inventors: Zixia Feng, Mark Hellberg
  • Topical formulations for treating allergic diseases
    Publication number: 20050288283
    Abstract: Methods for topically treating allergic diseases of the eye, ear or nose using tricyclic compounds are disclosed.
    Type: Application
    Filed: June 27, 2005
    Publication date: December 29, 2005
    Inventor: Mark Hellberg
  • Method of treating dry eye disorders and uveitis
    Publication number: 20050256189
    Abstract: The topical use of 5,6,7-trihydroxyheptanoic acid and analogs are disclosed for the treatment of dry eye disorders and uveitis.
    Type: Application
    Filed: May 12, 2005
    Publication date: November 17, 2005
    Inventors: Peter Klimko, Mark Hellberg, Daniel Gamache
  • Compounds with 5-HT1A activity useful for treating disorders of the outer retina
    Publication number: 20050256129
    Abstract: Compositions and methods for treating disorders of the outer retina with compounds with 5-HT1A agonist activity are disclosed.
    Type: Application
    Filed: July 22, 2005
    Publication date: November 17, 2005
    Inventors: Robert Collier, Michael Kapin, Mark Hellberg, Thomas Dean