Abstract: A system for making a nonwoven nonwoven spun-bond or melt-blown fabric has a spinneret for spinning fibers or filaments, a cooler downstream of the spinneret for cooling the spun fibers or filaments, a stretcher downstream of the cooler for stretching the cooled fibers or filaments, and a conveyor downstream of the stretcher. The stretched and cooled fibers or filaments are deposited as a nonwoven web on the conveyor. Sensors measure input parameters at the spinneret, at the cooler, at the stretcher, and/or at at least one diffuser or at the conveyor. An evaluating unit for determining an output parameter from the measured input parameter with respect to a predetermined reference parameter.

Abstract: A plastic film of a thermoplastic synthetic resin is made in a film-making system by extrusion from a die of an extruder. First the plastic is melted and extruded from the die as a tube or web that is, typically after cooling and stretching, formed into a package. At least one reference parameter is provided, and, during continuous operation of the system, two input parameters different from the reference parameter are measured by respective measuring devices An output is determined from these reference parameters and is compared with the reference parameter.

Abstract: A plastic-extrusion system comprises a plurality of system components including an extruder and a collection device for collecting the extruded plastic material. The plastic-extrusion system has an operator station designed for taking in and outputting data of the plastic-extrusion system. The operator station further has a mobile terminal including a screen of a graphical user interface as well as a camera. The plastic-extrusion system is associated with at least one information source, and preferably a plurality of information sources. The operator station is configured so as to provide access to the at least one information source, and preferably to the plurality of information sources.

Abstract: The invention relates to various aspects in the production of extrusion products. The properties of extruded articles are dependent significantly, in addition to their formulation, also on the setting variables and in particular on the thus resulting process variables. The setting variables and in particular the process variables thus represent a state of the extrusion process characterized as “fingerprint”. The thus claimed invention takes into account these facts and supports the operator of a production plant to detect earlier changes in quality and to systematically counteract a deterioration in the quality.

Abstract: The invention relates to various aspects in the production and further processing of plastic sheet material, in particular a spun-bonded non-woven fabric, a melt-blown non-woven fabric, a composite non-woven fabric, a blown film, a flat film, a plastic board or a plastic panel. A core aspect in the value chain of sheet material is a method and device for providing, retrieving and using a data element for exchanging in an over-lapping step-wise manner, a plurality of different data elements for producing the end product within the value chain of the sheet material. Within the value chain, it is possible to optimize the method using said data, to improve the construction of the used machines and systems and to improve the system technology as well as method technology for producing the sheet material.

Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth.

Abstract: A plastic-extrusion system comprises a plurality of system components including an extruder and a collection device for collecting the extruded plastic material. The plastic-extrusion system has an operator station designed for taking in and outputting data of the plastic-extrusion system. The operator station further has a mobile terminal including a screen of a graphical user interface as well as a camera. The plastic-extrusion system is associated with at least one information source, and preferably a plurality of information sources. The operator station is configured so as to provide access to the at least one information source, and preferably to the plurality of information sources.

Abstract: A system for making a nonwoven nonwoven spun-bond or melt-blown fabric has a spinneret for spinning fibers or filaments, a cooler downstream of the spinneret for cooling the spun fibers or filaments, a stretcher downstream of the cooler for stretching the cooled fibers or filaments, and a conveyor downstream of the stretcher. The stretched and cooled fibers or filaments are deposited as a nonwoven web on the conveyor. Sensors measure input parameters at the spinneret, at the cooler, at the stretcher, and/or at at least one diffuser or at the conveyor. An evaluating unit for determining an output parameter from the measured input parameter with respect to a predetermined reference parameter.

Abstract: A plastic film of a thermoplastic synthetic resin is made in a film-making system by extrusion from a die of an extruder. First the plastic is melted and extruded from the die as a tube or web that is, typically after cooling and stretching, formed into a package. At least one reference parameter is provided, and, during continuous operation of the system, two input parameters different from the reference parameter are measured by respective measuring devices An output is determined from these reference parameters and is compared with the reference parameter.

Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth.

Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth.

Abstract: The present disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R5, R6 and Z are as described herein. The disclosure also provides pharmaceutical compositions thereof; and methods for inhibiting DHFR activity; and methods for treating cell proliferative diseases, autoimmune disease, inflammatory disease or bacterial, fungal or parasitic infection by administering a compound of Formula I.

Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth.

Abstract: The present invention provides a pharmaceutical composition useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, an antibacterially effective combination of a ?-lactam antibiotic and an inhibitor of any bacterial peptidoglycan biosynthesis enzyme, especially GlmU, GlmU, MurA, MurB, MurC, MurD, MurE, MurF, MurG, MraY, and UppS.

Abstract: The present disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R5, R6 and Z are as described herein. The disclosure also provides pharmaceutical compositions thereof; and methods for inhibiting DHFR activity; and methods for treating cell proliferative diseases, autoimmune disease, inflammatory disease or bacterial, fungal or parasitic infection by administering a compound of Formula I.

Abstract: The present invention provides a pharmaceutical composition useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, an antibacterially effective combination of a ?-lactam antibiotic and an inhibitor of any bacterial peptidoglycan biosynthesis enzyme, especially GlmU, GlmU, MurA, MurB, MurC, MurD, MurE, MurF, MurG, MraY, and UppS.

Abstract: The present invention provides a pharmaceutical composition useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, an antibacterially effective combination of a ?-lactam antibiotic and an inhibitor of any bacterial peptidoglycan biosynthesis enzyme, especially GlmU, GlmU, MurA, MurB, MurC, MurD, MurE, MurF, MurG, MraY, and UppS.

Abstract: The invention provides a method for generating and selecting drug-sensitizing antisense DNA fragments. In one embodiment, the method includes identifying a gene of interest using knowledge of bacterial physiology, biochemistry, genetics, genomics, and other means. The method includes PCR amplification of a gene of interest using genomic DNA as a template; fragmentation of the DNA by sonication or other means; selecting DNA fragments no longer than 400 base pairs; ligating the DNA fragments into a suitable expression plasmid with a selectable marker; transforming the plasmids containing the DNA fragments into the organism from which the gene of interest originated; and selecting clones from transformed cells that show a phenotypic difference of the clone grown in the presence of the inducer relative to the phenotype in the absence of inducer.

Abstract: The invention provides a method for generating and selecting drug-sensitizing antisense DNA fragments. In one embodiment, the method includes identifying a gene of interest using knowledge of bacterial physiology, biochemistry, genetics, genomics, and other means. The method includes PCR amplification of a gene of interest using genomic DNA as a template; fragmentation of the DNA by sonication or other means; selecting DNA fragments no longer than 400 base pairs; ligating the DNA fragments into a suitable expression plasmid with a selectable marker; transforming the plasmids containing the DNA fragments into the organism from which the gene of interest originated; and selecting clones from transformed cells that show a phenotypic difference of the clone grown in the presence of the inducer relative to the phenotype in the absence of inducer.

Abstract: The invention provides a method for generating and selecting drug-sensitizing antisense DNA fragments. In one embodiment, the method includes identifying a gene of interest using knowledge of bacterial physiology, biochemistry, genetics, genomics, and other means. The method includes PCR amplification of a gene of interest using genomic DNA as a template; fragmentation of the DNA by sonication or other means; selecting DNA fragments no longer than 400 base pairs; ligating the DNA fragments into a suitable expression plasmid with a selectable marker; transforming the plasmids containing the DNA fragments into the organism from which the gene of interest originated; and selecting clones from transformed cells that show a phenotypic difference of the clone grown in the presence of the inducer relative to the phenotype in the absence of inducer.