Abstract: A computer implemented diagnostic amputation prevention system and method for evaluating risk factors and generating risk assessments and recommendations for diabetic patients at risk for amputation is provided. The system includes a diagnostic computer having a neurological/vascular module configured to electronically query and receive information related to pedal pulses, monofilament testing device results, or combinations thereof. A skeletal module electronically queries and receives Osseous Deformity information, and a database stores and aggregates the received information. A results module identifies risk factors using the aggregated information and generates diagnostics and recommendations based on factors including the amount, type, and particular combination of identified risk factors. The diagnostics and recommendations include identification of amputation risk assessment categories, explanation of risk categories, identified risk factors, recommendations for treatment, and combinations thereof.