Patents by Inventor Mark Howells

Mark Howells has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210293171
    Abstract: An exhaust mixer apparatus, emissions cleaning module, and a method of manufacturing the exhaust mixer apparatus is provided. The exhaust mixer apparatus comprises an exhaust conduit, a first exhaust mixer and a second exhaust mixer. The exhaust conduit is configured to extend in an elongate direction comprising an inlet and an outlet for transporting exhaust fluid. The first exhaust mixer comprises a plurality of elongate mixing blades each having a length extending in the elongate direction. The elongate mixing blades are connected together along at least part of their lengths and arranged about the elongate direction, each elongate mixing blade comprising an outer edge extending in the elongate direction. The elongate mixing blades are twisted along their lengths such that the outer edge of each elongate mixing blade is rotated about the elongate direction. The exhaust conduit is configured to locate the first exhaust mixer in an upstream location of the exhaust conduit.
    Type: Application
    Filed: July 15, 2019
    Publication date: September 23, 2021
    Applicant: Perkins Engines Company Limited
    Inventors: Mark ALDRED, Andrew HOWELL, Naseer NIAZ, Srikanth TUMMALA, Jean-Yves TILLIER, Mathew JOHNSON, Edward Long, Paul Gaynor
  • Patent number: 10813935
    Abstract: Disclosed herein are compositions and methods for treating cancer. Further provided herein are compositions and methods for reducing, inhibiting, or preventing resistance of cancer to tyrosine kinase inhibitors. The methods may include administering an anti-resistance agent such as a CYP51A1 inhibitor or an agonist of miRNA-764 (SEQ ID NO: 4) to a subject. A tyrosine kinase inhibitor may also be administered to the subject in addition to the anti-resistance agent.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: October 27, 2020
    Assignees: TRANSGENEX NANOBIOTECH, INC., University of South Florida
    Inventors: Subhra Mohapatra, Shyam S. Mohapatra, Mark Howell, Rajesh Nair
  • Publication number: 20200119683
    Abstract: A renewable-energy electrical generation and distribution system including a container. At least one power source is sized to be retained within the container and deployable therefrom, the at least one power source being configured to generate energy from renewable resources. A battery is disposed within the container and in communication with the at least one power source. A power distribution system is disposed within the container and in communication with the battery and the at least one power source, the power distribution system including: at least one switch and at least one interface connected to the at least one switch and disposed external to the container, the at least one switch configured selectively turn on and off power distribution to the at least one interface based on at least one predetermined parameter.
    Type: Application
    Filed: October 8, 2019
    Publication date: April 16, 2020
    Inventors: Fredric L. MILDER, Peter PAGE, Mark HOWELL
  • Patent number: 10587703
    Abstract: Technology for providing communication connectivity between network entities located in different isolated communication networks through a centralized cloud service. A cloud service connector in a source communication network receives an initial connection request from a source end point device in the source communication network, and determines a customer name and requested service associated with the port number indicated in the request. Mappings are established between the source end point device and a destination end point device that provides the requested service from within a destination communication network that is associated with the customer name.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: March 10, 2020
    Assignee: Citrix Systems, Inc.
    Inventors: Ricardo Fernando Feijoo, Kenneth Bell, Mark Howell, Manbir Chauhan
  • Publication number: 20190391119
    Abstract: A method for the automatic chromatography of thin-layer plates for thin-layer chromatography with a development chamber 1 in which a thin-layer plate D is completely enclosed, sealed-off and isolated from the external environment. In the development chamber, a front space containing an inner atmosphere is located on the front face of the separation layer of the thin-layer plate. The depth of the front space is about 2 mm and a maximum 3 mm. An inlet is provided at one end of the front space and an outlet is provided at the other end of the front space. During the chromatographic development, a stream of gas of particular composition determined by the user is created throughout the entire front space, the entire inner atmosphere being set in motion, without stagnant or stationary gas phase.
    Type: Application
    Filed: June 20, 2019
    Publication date: December 26, 2019
    Inventors: Bastian Gutmann, Nicolas Richerdt, Urs Lukas Schranz, Mark Howell Sturgess
  • Publication number: 20190391120
    Abstract: A method for the automatic chromatography of thin-layer plates for thin-layer chromatography with a development chamber 1 in which a thin-layer plate D is completely enclosed, sealed-off and isolated from the external environment. In the development chamber, a front space containing an inner atmosphere is located on the front face of the separation layer of the thin-layer plate. The depth of the front space is about 2 mm and a maximum 3 mm. An inlet is provided at one end of the front space and an outlet is provided at the other end of the front space. During the chromatographic development, a stream of gas of particular composition determined by the user is created throughout the entire front space, the entire inner atmosphere being set in motion, without stagnant or stationary gas phase.
    Type: Application
    Filed: June 19, 2019
    Publication date: December 26, 2019
    Inventors: Bastian Gutmann, Nicolas Richerdt, Urs Lukas Schranz, Mark Howell Sturgess
  • Patent number: 10338041
    Abstract: A derivatization apparatus and method for coating a sample carrier with a reagent solution. The derivatization apparatus consists of a closed system in which a small quantity of reagent solution is sprayed into a closed container via a spray nozzle. A sample carrier is located in the closed container and is coated as homogeneously as possible with the reagent solution.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: July 2, 2019
    Inventors: Nicolas Richerdt, Eike Reich, Mark Howell Sturgess, Diego Micha Haldemann
  • Publication number: 20190058768
    Abstract: Technology for providing communication connectivity between network entities located in different isolated communication networks through a centralized cloud service. A cloud service connector in a source communication network receives an initial connection request from a source end point device in the source communication network, and determines a customer name and requested service associated with the port number indicated in the request. Mappings are established between the source end point device and a destination end point device that provides the requested service from within a destination communication network that is associated with the customer name.
    Type: Application
    Filed: January 19, 2018
    Publication date: February 21, 2019
    Inventors: Ricardo Fernando Feijoo, Kenneth Bell, Mark Howell, Manbir Chauhan
  • Publication number: 20180256579
    Abstract: Disclosed herein are compositions and methods for treating cancer. Further provided herein are compositions and methods for reducing, inhibiting, or preventing resistance of cancer to tyrosine kinase inhibitors. The methods may include administering an anti-resistance agent such as a CYP51A1 inhibitor or an agonist of miRNA-764 (SEQ ID NO: 4) to a subject. A tyrosine kinase inhibitor may also be administered to the subject in addition to the anti-resistance agent.
    Type: Application
    Filed: February 23, 2018
    Publication date: September 13, 2018
    Inventors: Subhra Mohapatra, Shyam S. Mohapatra, Mark Howell, Rajesh Nair
  • Publication number: 20180170590
    Abstract: Various embodiments of a product packing apparatus are disclosed. Embodiments may include a rotating head assembly configured to selectively rotate all or a portion of unique feed lines, to generate a desired packaging configuration. For example, embodiments of the present approach may be used to package bottles or cans of various beverage varieties. A plurality of feedlines may direct beverage varieties towards a rotating head assembly. Each feedline may deliver a specific beverage variety. Depending on the desired packaging configuration, some feedlines may divert around the rotating head assembly, whereas others deliver beverage varieties in linear arrays to the rotating head assembly. The rotating head assembly rotates a select portion of the beverage varieties to generate a desired packaging configuration of beverage varieties.
    Type: Application
    Filed: April 6, 2017
    Publication date: June 21, 2018
    Inventor: Mark Howell WOJDYLA
  • Publication number: 20170299560
    Abstract: A derivatization apparatus and method for coating a sample carrier with a reagent solution. The derivatization apparatus consists of a closed system in which a small quantity of reagent solution is sprayed into a closed container via a spray nozzle. A sample carrier is located in the closed container and is coated as homogeneously as possible with the reagent solution.
    Type: Application
    Filed: April 13, 2017
    Publication date: October 19, 2017
    Inventors: Nicolas Richerdt, Eike Reich, Mark Howell Sturgess, Diego Micha Haldemann
  • Patent number: 9730691
    Abstract: A staple clip for providing an attachment function in a surgical procedure is described. A center hub has a center hub aperture. The center hub defines a lateral hub plane. A plurality of joining legs each has an inner leg end attached to the center hub and an outer foot defining a lateral foot plane. The inner leg end and outer foot are separated along the leg by an elongate leg body extending laterally outward and longitudinally downward from the center hub. A plurality of lobe pads are attached to the center hub and lie substantially within the lateral hub plane. The inner leg ends and lobe pads alternate with each other around a periphery of the center hub.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: August 15, 2017
    Assignee: The Cleveland Clinic Foundation
    Inventors: Eric E. Roselli, Ryan S. Klatte, Mark S. Lobosky, Mark Howell
  • Patent number: 9193079
    Abstract: A linkage mechanism for a wet shaving razor is provided. The linkage mechanism is pivotally connected to and suspended from the handle at one end and pivotally and removably attached to the cartridge carrier at an opposite end allowing the cartridge carrier to pivot about a virtual pivot axis located below the shaving plane and into the skin. The linkage mechanism provides flexibility in positioning the virtual pivot axis since it is not limited to the physical constraints of the cartridge. As a result, the shaving razor cartridge has a flatter contact with the skin throughout the shaving stroke providing shaving comfort with reduced nicks and cuts.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: November 24, 2015
    Assignee: The Gillette Company
    Inventors: Daren Mark Howell, Ian Anthony Goodhead, Terence Gordon Royle
  • Patent number: 9015951
    Abstract: A razor cartridge has a housing, a guard located at a front of the housing and a cap located at a rear of the housing. A skin contact element is disposed in the housing partway between the guard and the cap. A skin contact plane defines a plane tangential to the guard and the skin contact element and a plane tangential to the skin contact element and the cap. One or more blades are located between the guard and the skin contact element, each of the blades having a cutting edge located at a distance y1 between 70 ?m and 300 ?m and at an angle ?1 between 20° and 45° below the skin contact plane. One or more blades are located between the skin contact element and the cap, each of the blades having a cutting edge located at an angle ?2 above or below the skin contact plane, wherein ?2 is lower in magnitude than ?1.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: April 28, 2015
    Assignee: The Gillette Company
    Inventors: Daren Mark Howell, Andrew Martin Whittingham
  • Publication number: 20140224858
    Abstract: A staple clip for providing an attachment function in a surgical procedure is described. A center hub has a center hub aperture. The center hub defines a lateral hub plane. A plurality of joining legs each has an inner leg end attached to the center hub and an outer foot defining a lateral foot plane. The inner leg end and outer foot are separated along the leg by an elongate leg body extending laterally outward and longitudinally downward from the center hub. A plurality of lobe pads are attached to the center hub and lie substantially within the lateral hub plane. The inner leg ends and lobe pads alternate with each other around a periphery of the center hub.
    Type: Application
    Filed: February 12, 2014
    Publication date: August 14, 2014
    Applicant: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Eric E. Roselli, Ryan S. Klatte, Mark S. Lobosky, Mark Howell
  • Patent number: 8769825
    Abstract: A shaving razor that improves stability, corresponding user control and offers a closer shave is provided. The shaving razor can include a razor handle configuration that reduces the propensity for the shaving razor to roll in a users hand and improves the maneuverability of the razor cartridge during shaving. In addition, the shaving razor can include a biasing pivoting member producing a progressively increasing return torque on the razor cartridge that forces the cartridge into flat contact with the skin thus improving glide and shaving closeness.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: July 8, 2014
    Assignee: The Gillette Company
    Inventors: Daren Mark Howell, David John O'Callaghan, Andrew Martin Whittingham
  • Patent number: 8732955
    Abstract: A shaving razor that offers a closer shave is provided. The shaving razor can include a biasing member producing a progressively increasing return torque on the razor cartridge that forces the cartridge into flat contact with the skin as the cartridge pivots, thus improving glide and shaving closeness. In addition, the shaving razor can include a razor handle configuration that reduces the propensity for the shaving razor to roll in a user's hand and improves the maneuverability of the razor cartridge during shaving.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: May 27, 2014
    Assignee: The Gillette Company
    Inventors: Daren Mark Howell, David John O'Callaghan, Andrew Martin Whittingham
  • Patent number: 8729065
    Abstract: Described are crystalline forms of the pharmaceutical compound “[9S-(9?,10?,12?)]-5,16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3?,2?,1?-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester”, as well as methods for their use and preparation.
    Type: Grant
    Filed: January 3, 2011
    Date of Patent: May 20, 2014
    Assignee: Cephalon, Inc.
    Inventors: Michael Harold Rock, Heidi Lopez De Diego, Kim Lasse Christensen, Ole Nielsen, Anders Buur, Mark Howells
  • Patent number: 8650763
    Abstract: A shaving razor that improves stability, corresponding user control and offers a closer shave is provided. The shaving razor can include a razor handle configuration that reduces the propensity for the shaving razor to roll in a user's hand and improves the maneuverability of the razor cartridge during shaving. In addition, the shaving razor can include a biasing pivoting member producing a progressively increasing return torque on the razor cartridge that forces the cartridge into flat contact with the skin thus improving glide and shaving closeness.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: February 18, 2014
    Assignee: The Gillette Company
    Inventors: Daren Mark Howell, David John O'Callaghan, Andrew Martin Whittingham
  • Publication number: 20130160307
    Abstract: A razor blade assembly having a razor cartridge connected to a handle via a pivoting mechanism. The razor cartridge rotates about a virtual pivot axis produced by the pivoting mechanism. The virtual pivot axis is positioned in a virtual pivot axis region located forward of the cartridge midpoint toward the front edge of the cartridge and into the skin.
    Type: Application
    Filed: December 22, 2011
    Publication date: June 27, 2013
    Inventors: Daren Mark Howell, Ian Anthony Goodhead