Patents by Inventor Mark Humayun

Mark Humayun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180271702
    Abstract: A cannula insertion system configured to divide a cannula insertion process into a two-step process. The first step advances a needle portion a first distance and the second step advances the needle portion a second distance. The first step and the second step may be at different angles. At least one of the angles may be less than 90°. At least one of the steps may be mechanically assisted.
    Type: Application
    Filed: June 4, 2018
    Publication date: September 27, 2018
    Inventors: Mark Humayun, Jaw-Chyng Lormen Lue
  • Patent number: 10076359
    Abstract: Various adjustable cannula systems are provided. The systems can include an adjustable cannula capable of expansion and/or contraction having an elongate body with a distal end and a proximal end. The adjustable cannula can be coupled to an upper housing and a lower housing such that rotation of the upper housing results in expansion or contraction of the adjustable cannula. The adjustable cannula can also have a proximal end having a lumen larger than a distal end lumen. A plurality of flanges can be formed in the elongate body by a plurality of slits that span a majority of a length of the cannula, including along or proximate to its proximal end and distal end.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: September 18, 2018
    Assignee: DOHENY EYE INSTITUTE
    Inventors: Ralph Kerns, Prashant Bhadri, Matthew McCormick, Anderson Gustavo Teixeira Pinto, Mark Humayun, Luis Arana
  • Patent number: 10070934
    Abstract: A surgical apparatus for use by a surgeon can include a tray and a plurality of surgical instruments. The tray can have a plurality of structures located on an upper side of the tray for receiving the plurality of surgical instruments. The tray can receive a separate control unit. The tray can also have a fluid reservoir receiver for receiving a bottle or container of fluid, such as balanced salt solution. The fluid reservoir receiver can include one or more features, including, a spike, an air vent, and a light. A separate container can be used to place the bottle or container of fluid into the fluid reservoir receiver on the tray. This separate container can include a collapsible section.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: September 11, 2018
    Assignee: Doheny Eye Institute
    Inventors: Ralph Kerns, Mark Humayun, Matthew T. McCormick, Trent Spencer Wells, Lawrence Chong, Jaw Chyng Lue
  • Publication number: 20180250088
    Abstract: The disclosure herein provides ophthalmic surgical systems, methods, and devices. In one embodiment, a surgical apparatus for use by a surgeon during a surgical procedure comprises one or more sealed sterilized surgical packs configured to be disposed of after a single or a limited number of surgical procedures, the one or more sealed sterilized surgical packs comprising: a sterile surgical instrument; and a sterile surgical tray comprising a top surface configured to be part of a sterile field of the surgical procedure, the top surface comprising a receiving structure for positioning therein of the sterile surgical instrument, the sterile surgical tray further comprising walls that define a recess sized and configured to receive a reusable non-sterile module, the recess configured to encapsulate the reusable non-sterile module to isolate the reusable non-sterile module from the sterile field of the surgical procedure.
    Type: Application
    Filed: May 3, 2018
    Publication date: September 6, 2018
    Inventors: Jeffrey David Brennan, Mark Humayun
  • Patent number: 9999542
    Abstract: A cannula insertion system configured to divide a cannula insertion process into a two-step process. The first step advances a needle portion a first distance and the second step advances the needle portion a second distance. The first step and the second step may be at different angles. At least one of the angles may be less than 90°. At least one of the steps may be mechanically assisted.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: June 19, 2018
    Assignee: DOHENY EYE INSTITUTE
    Inventors: Mark Humayun, Jaw-Chyng Lormen Lue
  • Patent number: 9987417
    Abstract: In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: June 5, 2018
    Assignee: MINIPUMPS, LLC
    Inventors: Jason Shih, Yu-Chong Tai, Changlin Pang, Sean Caffey, Raymond Peck, Fukang Jiang, Mark Humayun
  • Patent number: 9962226
    Abstract: The disclosure herein provides ophthalmic surgical systems, methods, and devices. In one embodiment, a surgical apparatus for use by a surgeon during a surgical procedure comprises one or more sealed sterilized surgical packs configured to be disposed of after a single or a limited number of surgical procedures, the one or more sealed sterilized surgical packs comprising: a sterile surgical instrument; and a sterile surgical tray comprising a top surface configured to be part of a sterile field of the surgical procedure, the top surface comprising a receiving structure for positioning therein of the sterile surgical instrument, the sterile surgical tray further comprising walls that define a recess sized and configured to receive a reusable non-sterile module, the recess configured to encapsulate the reusable non-sterile module to isolate the reusable non-sterile module from the sterile field of the surgical procedure.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: May 8, 2018
    Assignee: ALCON PHARMACEUTICALS LTD.
    Inventors: Jeffrey David Brennan, Mark Humayun
  • Patent number: 9943405
    Abstract: Advances in filling apparatus, handheld tools, surgical techniques and intraoperative biometry for implanting and adjusting an accommodative liquid lens are disclosed. The lens may be attached to or retained within a handheld surgical tool, which can be fluidly connectable to a filling console to fill the lens with a liquid. In various embodiments, a filling console facilitates aspirating liquid out of the lens in order to ensure the absence of residual bubbles and filling of the lens with fluid during surgery, as well as during post-operative adjustments to the lens. Actuated by the surgeon, the filling console can aspirate fluid from the lens and inject fluid into the lens following insertion thereof.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: April 17, 2018
    Assignee: ICO, INC.
    Inventors: Sean Caffey, Charles DeBoer, Mark Humayun, Yu-Chong Tai
  • Patent number: 9844578
    Abstract: Disclosed herein are methods for treating eye injuries by administering one or more angiotensin peptides to a subject with an eye injury.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: December 19, 2017
    Assignee: University of Southern California
    Inventors: Kathleen E. Rodgers, Gere S. Dizerega, Mark Humayun, Stan Louie, Walid Fouad Ahmed Abdallah
  • Publication number: 20170347883
    Abstract: A first light source producing a first light beam with a first intensity and a second light source producing a second light beam with a second intensity. A light filter device receives the first light beam and transmits a filtered portion of the first light beam. A first angling device reflects the filtered portion of the first light beam in a first angled direction and a second angling device reflects the second light beam in a second angled direction. A mirror receives and in turn reflects the filtered portion of the first light beam reflected by the first angling device and the second light beam reflected by the second angling device to form a converged light beam with a third intensity.
    Type: Application
    Filed: August 18, 2017
    Publication date: December 7, 2017
    Inventors: Prashant Bhadri, James Lescoulie, Sophia Fang, Matthew McCormick, Ralph Kerns, Mark Humayun, Aaron Barnes
  • Publication number: 20170319386
    Abstract: A biological tissue cutting and fluid aspiration system provides a plurality of surgical instruments operable independent of an external control console. In some embodiments, each surgical instrument may include all sensors and controls directly applicable to the surgical instrument, and may be used independently. In some embodiments, instruments communicate status information to each other, and adjust operating parameters based on the communications.
    Type: Application
    Filed: July 21, 2017
    Publication date: November 9, 2017
    Inventors: Mark Humayun, Charles DeBoer, Ralph Kerns, Matthew McCormick, Prashant Bhadri, Lawrence Chong
  • Patent number: 9730833
    Abstract: A biological tissue cutting and fluid aspiration system provides a plurality of surgical instruments operable independent of an external control console. In some embodiments, each surgical instrument may include all sensors and controls directly applicable to the surgical instrument, and may be used independently. In some embodiments, instruments communicate status information to each other, and adjust operating parameters based on the communications.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: August 15, 2017
    Assignee: Doheny Eye Institute
    Inventors: Mark Humayun, Charles DeBoer, Ralph Kerns, Matthew McCormick, Prashant Bhadri, Lawrence Chong
  • Publication number: 20170196221
    Abstract: Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
    Type: Application
    Filed: January 27, 2017
    Publication date: July 13, 2017
    Inventors: Danhong Zhu, David Hinton, Ashish Ahuja, Mark Humayun
  • Patent number: 9693894
    Abstract: Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: July 4, 2017
    Assignee: THE UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Yu-Chong Tai, Mark Humayun, Jason Shih
  • Patent number: 9642940
    Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 ?m to 5 ?m thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The application further provides an implantable cage-like apparatus for culturing cells comprising the parylene membrane.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: May 9, 2017
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Bo Lu, Mark Humayun
  • Patent number: 9636656
    Abstract: Methods are described and related devices, compositions, and systems, in which a caged compound is administered to a biological environment, the caged compound being caged with a long wavelength absorber, the long wavelength being a wavelength greater than or equal to 750 nm; and irradiating the biological environment to excite the long wavelength absorber with light at a wavelength in a range from 900-1100 nm, thus decaging the compound.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: May 2, 2017
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, University of Southern California
    Inventors: Dennis A. Dougherty, Robert H. Grubbs, Mark Humayun, Clinton J. Regan, Azita Emami
  • Patent number: 9623174
    Abstract: In various embodiments, an implantable pump includes a cannula. The pump (e.g., the cannula thereof) may include, for example, flow sensors, pressure sensors, filters, and/or other components.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: April 18, 2017
    Assignee: MINIPUMPS, LLC
    Inventors: Changlin Pang, Jason Shih, Fukang Jiang, Sean Caffey, Mark Humayun, Yu-Chong Tai
  • Publication number: 20170095309
    Abstract: A sterile surgical tray includes structure for receiving a plurality of surgical instruments. The sterile surgical tray also may include electrical input and output connectors attached to tray.
    Type: Application
    Filed: December 16, 2016
    Publication date: April 6, 2017
    Inventors: Mark Humayun, Charles DeBoer, Matthew McCormick, Prashant Bhadri, Joel Cicchella, Ralph Kerns
  • Patent number: 9603997
    Abstract: Implanted drug pump devices can be refilled with a refill needle inserted through a fill port in the drug reservoir of the drug pump device. Proper needle insertion may be verified visually or using electrical, magnetic, optical, acoustic, or other suitable sensing mechanisms.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: March 28, 2017
    Assignee: MINIPUMPS, LLC
    Inventors: Mark Humayun, Yu-Chong Tai, Nenad Jelisavcic, Julian D. Kavazov, Fukang Jiang
  • Publication number: 20170035523
    Abstract: A surgical apparatus for use by a surgeon can include a tray and a plurality of surgical instruments. The tray can have a plurality of structures located on an upper side of the tray for receiving the plurality of surgical instruments. The tray can receive a separate control unit. The tray can also have a fluid reservoir receiver for receiving a bottle or container of fluid, such as balanced salt solution. The fluid reservoir receiver can include one or more features, including, a spike, an air vent, and a light. A separate container can be used to place the bottle or container of fluid into the fluid reservoir receiver on the tray. This separate container can include a collapsible section.
    Type: Application
    Filed: October 3, 2016
    Publication date: February 9, 2017
    Inventors: Ralph Kerns, Mark Humayun, Matthew T. McCormick, Trent Spencer Wells, Lawrence Chong, Jaw Chyng Lue