Patents by Inventor Mark I. Donnelly

Mark I. Donnelly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to produce succinic acid from raw hydrolysates
    Patent number: 6743610
    Abstract: A method for producing succinic acid from industrial-grade hydrolysates is provided, comprising supplying an organism that contains mutations for the genes ptsG, pflB, and ldhA, allowing said organism to accumulate biomass, and allowing said organism to metabolize the hydrolysate. Also provided is a bacteria mutant characterized in that it produces succinic acid from substrate contained in industrial-grade hydrolysate in a ratio of between 0.6:1 and 1.3:1 succinic acid to substrate.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: June 1, 2004
    Assignee: The University of Chicago
    Inventors: Mark I. Donnelly, Cynthia Y. Sanville-Millard, Nhuan Phu Nghiem
  • Method to produce succinic acid from raw hydrolysates
    Publication number: 20030017559
    Abstract: A method for producing succinic acid from industrial-grade hydrolysates is provided, comprising supplying an organism that contains mutations for the genes ptsG, pflB, and ldhA, allowing said organism to accumulate biomass, and allowing said organism to metabolize the hydrolysate. Also provided is a bacteria mutant characterized in that it produces succinic acid from substrate contained in industrial-grade hydrolysate in a ratio of between 0.6:1 and 1.3:1 succinic acid to substrate.
    Type: Application
    Filed: March 30, 2001
    Publication date: January 23, 2003
    Inventors: Mark I. Donnelly, Cynthia Y. Sanville-Millard, Nhuan Phu Nghiem
  • Method for construction of bacterial strains with increased succinic acid production
    Patent number: 6159738
    Abstract: A fermentation process for producing succinic acid is provided comprising selecting a bacterial strain that does not produce succinic acid in high yield, disrupting the normal regulation of sugar metabolism of said bacterial strain, and combining the mutant bacterial strain and selected sugar in anaerobic conditions to facilitate production of succinic acid. Also provided is a method for changing low yield succinic acid producing bacteria to high yield succinic acid producing bacteria comprising selecting a bacterial strain having a phosphotransferase system and altering the phosphotransferase system so as to allow the bacterial strain to simultaneously metabolize different sugars.
    Type: Grant
    Filed: April 28, 1998
    Date of Patent: December 12, 2000
    Assignee: University of Chicago
    Inventors: Mark I. Donnelly, Cynthia Sanville-Millard, Ranjini Chatterjee