Abstract: The present disclosure includes engineering methods and polypeptide libraries that are useful for introducing non-native binding sites into polypeptides. Also provided herein are polypeptides that bind to a CD98hc or transferrin receptor (TfR) protein, methods of generating such polypeptides, and methods of using the polypeptides to target a composition across the blood-brain barrier or to a CD98hc-expressing or TfR-expressing cell.

Abstract: The present invention relates to methods for the production of a solid urea-thiosulfate fertilizer wherein the method comprises preparing a liquid urea-thiosulfate blend comprising 70-90 wt. % urea and 10-30 wt. % thiosulfate salt and processing this blend in liquid form. Various process steps such as evaporation and/or transport to the solidification apparatus can be performed with decreased energy usage and decreased thiosulfate decomposition since the melting point of the blend is significantly lower than the melting point of a regular urea melt.

Abstract: Methods and systems may be used to control the output parameters of one or more light sources (e.g., discrete-spectrum light sources) based on fixture capability information. Fixture capability information may be obtained using a configuration tool. The fixture capability information may be determined by the configuration tool, and the fixture capability information determined by the configuration tool may be stored and/or processed. The fixture may have a memory for storing the fixture capability information. The fixture capability information may also be stored in a remote network device. A system controller may obtain the fixture capability information from the fixture or the remote control device. The system controller may generate control instructions based on the fixture capability information and send the control instructions to the fixtures.

Abstract: A personal vapor inhaling unit is disclosed. An electronic flameless vapor inhaler unit that may simulate a cigarette has a cavity that receives a cartridge in the distal end of the inhaler unit. The cartridge brings a substance to be vaporized in contact with a wick. When the unit is activated, and the user provides suction, the substance to be vaporized is drawn out of the cartridge, through the wick, and is atomized by the wick into a cavity containing a heating element. The heating element vaporizes the atomized substance. The vapors then continue to be pulled by the user through a mouthpiece and mouthpiece cover where they may be inhaled.

Abstract: A picture frame comprising a picture carrier portion and a frame portion, the frame portion for formation of a frame and comprising frame members with: a side member hingedly connected via a first hinge connection to the picture carrier portion; a back member hingedly connected via a second hinge connection to the side member, wherein in an assembled configuration: the side member forms an side of the frame; the back member forms a back of the frame and is inclined relative the carrier portion to extend from the side member to the picture carrier portion.

Abstract: A personal vapor inhaling unit is disclosed. An electronic flameless vapor inhaler unit that may simulate a cigarette has a cavity that receives a cartridge in the distal end of the inhaler unit. The cartridge brings a substance to be vaporized in contact with a wick. When the unit is activated, and the user provides suction, the substance to be vaporized is drawn out of the cartridge, through the wick, and is atomized by the wick into a cavity containing a heating element. The heating element vaporizes the atomized substance. The vapors then continue to be pulled by the user through a mouthpiece and mouthpiece cover where they may be inhaled.

Abstract: A golf club head having discreet regions of specific mass relationships, including a lightweight forward portion, to achieve specific mass properties and performance.

Abstract: The disclosure provides a method for forming a core layer for a plurality of information carrying cards, a resulting core layer, and a resulting information carrying card. A first portion of a crosslinkable polymer composition is dispensed onto the first thermoplastic layer. A second thermoplastic layer having a plurality of through-holes therein is then applied. A second portion of the crosslinkable polymer composition is dispensed into each through-hole. An inlay layer is placed over the polymer composition inside each through-hole. A third portion of the crosslinkable polymer composition is dispensed over each inlay layer. A third thermoplastic layer or a release film is placed over the third portion of the crosslinkable polymer composition to provide a layered structure. Each respective inlay layer is configured to be movable and/or self-center inside each through-hole in the presence of the crosslinkable polymer composition when the layered structure is pressed on a pressure.

Abstract: A computer system comprises at least one processor; a communications module coupled to the at least one processor; and a memory coupled to the at least one processor and storing processor-executable instructions which, when executed by the at least one processor, configure the at least one processor to provide a bidirectional application programming interface that interfaces between at least one provider system and at least one subscriber system, the bidirectional application programming interface configured to allow the at least one provider system to make requests of the at least one subscriber system and to allow the at least one subscriber system to make requests of the at least one provider system; receive, from a subscriber system, an application programming interface request that includes a request to confirm data processing particulars; identify, based on the data processing particulars, a provider system associated with the data processing particulars; send, to the provider system, the request to con

Abstract: A system and method for algorithmic selection of a consensus from a collection of ideas is disclosed. A group of ideas is provided to a group of participants for voting. Voting may occur in a single round or in several successive rounds, optionally until a consensus idea is chosen. Typically, the votes that are cast use discrete levels, such as “approve”, “disapprove”, “positive”, “neutral” or “negative”. For ideas that receive the same votes, a differentiator may be the time spent casting the vote. A relatively long evaluation time may signal some internal conflict in the mind of the participant, when compared with a relatively short evaluation time, which may signal no such conflict. The evaluation time may be combined with the rating of the participant to form a weighted rating. Consequently, a short evaluation time of a positive rating may yield a more positive weighted rating, while a short evaluation time of a negative rating may yield a more negative weighted rating.

Abstract: Processes for identification of binding sites on protein molecules such as epitopes are provided. The disclosed methods in some embodiments use a combination of protein sequence data, structural information, experimental data on binding affinity, and computational modeling in order to identify binding sites on protein molecules. Systems and computer readable media for implementing the disclosed methods are provided. Also provided are compositions comprising a binding site or antibody that interacts with the binding site as an active ingredient and methods of using such compositions.

Abstract: A Munitions Payload Delivery System (MPDS) is provided. One embodiment of the MPDS comprises a multi-rotor drone configured to carry a munition in the form of a HEDP linear-shaped charge or Armor Piercing munition or other-shaped munition. The drone, in one embodiment, includes a camera that provides a remote operator with a real-time video feed so the operator can pilot the drone to a specific target on a battlefield. Once a target is selected, the operator ignites the munition by flying the drone into the target, landing the drone on the target, or activating a radio fire button. In one embodiment, each of these mechanisms closes a switch on board the drone connecting a voltage to a blasting cap inside the payload.

Abstract: A liquid composition for providing enhanced lubrication and wear protection, particularly under high-performance and/or extreme-pressure conditions. The composition comprises components that are solubilized, liquified, liquefacted, or sub-micronized, and are formulated to result in a stable, color-tunable composition that can be stored or implemented over extended periods of time without separation of solid components from the liquid. A composition can be a lubricant in which the solubilized, liquified, liquefacted, and/or sub-micronized components are comprised within a base oil, or an additive composition in which the components are formulated to be later added to a base oil.

Abstract: A deployable stabilizer cooperates with a tape of a tape measure to stabilize the tape measure with the tape extended therefrom to facilitate hands free stability of the tape measure. The stabilizer may be pivotally coupled with a body of the tape measure to facilitate pivoting between a deployed and a stowed position. The stabilizer may comprise an extendable member that is guided by channels defined by tape measure body. Locations or orientations of pivot holes or channel guides may result in contact of the bottom of the tape in an extended position with a top of the stabilizer in a deployed position to facilitate stability of the tape measure body.

Abstract: An articulable sleep system has a first head section, a second head section, and a joined leg section that are each separable articulable. A head motor system includes a first and second head motors operably connected to the first and second head sections. A leg motor system includes first and second leg motors operably connected to the joined leg section. A first user controlling device is hard wired to each of the first head motor, the first leg motor, and the second leg motor. A second user controlling device hard wired to each of the second head motor, the first leg motor, and the second leg motor.

Abstract: Surgical anchors and related systems and methods that utilize sutures or other flexible, elongated members to actively deploy a deformable anchor body in a manner that facilitates better deployment of the anchor in the bone, resulting in better fixation and resistance to pull out.

Abstract: An implant insertion tool includes an outer shaft, an inner shaft received in the outer shaft, and two arms coupled to the outer shaft and the inner shaft. The inner shaft translates within the outer shaft and has angled ramps that slide within complementary angled ramps in the two arms. The arms engage an implant for insertion into a body. When the inner shaft translates along a longitudinal axis, it causes the angled ramps to slide against the complementary angled ramps in the arms such that the two arms move laterally relative to the longitudinal axis of the outer shaft to engage and disengage the implant.

Abstract: An example stimulation device for a male penis includes a pressure field generation device for generating a pneumatic alternating pressure field, and an applicator for applying the alternating pressure field to a portion of a penis that is to be stimulated. The applicator has a pressure chamber, which can receive an alternating pressure field generated by the pressure field generation device. The pressure chamber has an opening in a contact region of the applicator, so that the alternating pressure field can be applied directly to a portion of the penis that is to be stimulated via the opening. A sealing device is arranged on the applicator, which is configured to seal the pressure chamber against the environment when the applicator is applied to the penis.

Abstract: A preform for a composite may include a plurality of fibrous layers consolidated together and forming the preform extending along a longitudinal axis. The plurality of fibrous layers includes at least one first fibrous layer and at least one second fibrous layer. The at least one first fibrous layer includes a plurality of first segments, and the least one second fibrous layer includes a plurality of second segments. At least one first segment of the plurality of first segments includes a plurality of reinforcing fibers extending at an angle ?? relative to a radial direction extending from the longitudinal axis. At least one second segment of the plurality of second segments includes a plurality of reinforcing fibers extending at an angle +? relative to the radial direction. ? is greater than 0° and less than 90°.

Abstract: The refuse lift arm system includes a grabber device configured to engage the refuse container and a container lift. The container lift includes a carriage, a rail assembly, and a tipping mechanism. The carriage supports pivotal movement of the grabber device. The rail assembly supports translational movement of the carriage. The tipping mechanism is configured to pivot the grabber device relative to the carriage in response to relative movement between the carriage and the rail assembly. The refuse lift arm system further includes a horizontal positioning system configured to move the rail assembly laterally relative to the refuse collection vehicle.