Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.

Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.

Abstract: An approach to printing a nickel precursor ink on a wide range of substrates for electronics and magnetic applications is disclosed. The nickel ink reduces to elemental nickel following heating. The ink was printed using an ultrasonic aerosol printing technique. By sintering the nickel precursor ink in the presence of a homogeneous magnetic field, the reduced nickel complex formed continuously aligned nickel nanofibers axially aligned with the direction of the magnetic field. The fabrication of aligned interlayered nanofiber films provides opportunities to produce structures with enhanced isotropic electrical and magnetic properties. The resistivity of the film was found to be as low as 0.56 m?·cm, and the saturation magnetization was measured to be 30 emu/g, which is comparable to bulk Ni. Magnetic anisotropy was induced with an easy axis along the direction of the applied magnetic field with soft magnetic properties.

Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.

Abstract: An approach to printing a nickel precursor ink on a wide range of substrates for electronics and magnetic applications is disclosed. The nickel ink reduces to elemental nickel following heating. The ink was printed using an ultrasonic aerosol printing technique. By sintering the nickel precursor ink in the presence of a homogeneous magnetic field, the reduced nickel complex formed continuously aligned nickel nanofibers axially aligned with the direction of the magnetic field. The fabrication of aligned interlayered nanofiber films provides opportunities to produce structures with enhanced isotropic electrical and magnetic properties. The resistivity of the film was found to be as low as 0.56 m?·cm, and the saturation magnetization was measured to be 30 emu/g, which is comparable to bulk Ni. Magnetic anisotropy was induced with an easy axis along the direction of the applied magnetic field with soft magnetic properties.

Abstract: Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted by “B”, T, R3, R4, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

Abstract: A method and system for preventing error during data replication is provided. A replication entity model is used to represent data in a source and data in a target. One or more of a logical model, a directed relationship model or a state model may be provided to prevent error. The method and system may be applied to data migration and data synchronisation. The system comprises a transformation engine and a replication engine, wherein the replication engine is adapted to instruct the transformation engine to replicate each replication entity in turn. This may be based on the order dictated by the one or more directed relationships in the directed relationship model. Replication of a replication entity by the transformation engine comprises replicating data within one or more selected data structures of the source in one or more selected data structures of the target, the selection being based on the mapping between the replication entity model data in the source and data in the target.

Abstract: The invention relates to a process for forming a stacked transparent structure comprising providing a support, coating one side of said support with a multicolored mask, coating the other side of the support with a layer curable by visible light, and exposing the light-curable layer through the mask with visible light to cure the layer curable by light in exposed portions to form a cured pattern.

Abstract: An article comprising a substrate and a patterned electrically conductive metal phase, wherein the electrically conductive metal phase is selectively deposited on the substrate via sequential or simultaneous ink jetting of combinations of a reducible soluble metal salt, a reduction catalyst and a reducing agent. On substrates having layered structures, the selectively deposited electrically conductive metal phase is intertwined with the substrate microstructure. A method of forming the same is also provided. In a particular embodiment of the method, the selective deposition of the electrically conductive phase onto the substrate comprises a first jetting of a composition comprising the reducible soluble metal salt and the reduction catalyst in a predetermined area followed by a subsequent jetting of a composition comprising the reducible metal salt and the reducing agent over the same predetermined area.

Abstract: A package of thermographic or photothermographic materials has a primary packaging enclosure, and optionally a secondary packaging enclosure, containing one or more of the materials (such as individual sheets). A non-photosensitive indicator device is associated with either or both of the packaging enclosures. This non-photosensitive indicator device is adapted to provide a visually observable indication of a predetermined cumulative thermal exposure and a predetermined temperature event (that is, single temperature event) of the package. This indicator device is able to provide information as to the time-temperature history of the package.

Abstract: An article comprising a substrate and a patterned electrically conductive metal phase, wherein the electrically conductive metal phase is selectively deposited on the substrate via sequential or simultaneous ink jetting of combinations of a reducible soluble metal salt, a reduction catalyst and a reducing agent. On substrates having layered structures, the selectively deposited electrically conductive metal phase is intertwined with the substrate microstructure. A method of forming the same is also provided. In a particular embodiment of the method, the selective deposition of the electrically conductive phase onto the substrate comprises a first jetting of a composition comprising the reducible soluble metal salt and the reduction catalyst in a predetermined area followed by a subsequent jetting of a composition comprising the reducible metal salt and the reducing agent over the same predetermined area.

Abstract: A method of detonating explosive charges for the breaking of rock and ore comprises the use of two sets of components, one set within the explosive charge and the other set at the surface of the explosive. The set within the exposive comprises a detonator, a first delay element and a passive energy storage device such as a capacitor. The second set which is able to communicate with the first comprises a power source, a second delay element and a means for receiving signals from a remote command source. In a preferred embodiment, the first delay element has a fixed delay and the second delay element has a programmable delay.The method permits of versatility and precision in the use of explosives, using relatively inexpensive components.