Patents by Inventor Mark J. Brierton
Mark J. Brierton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230285880Abstract: Biological fluid processing cassettes with integrated filter structures are disclosed. A cassette body is formed of a generally rigid material, defining a plurality of internal fluid flow paths. The cassette body may be secured to a cassette cap to define a cavity, with a filter sealed within the cavity. Each of the cassette body and the cassette cap defines a port opening into the cavity, which allows fluid to flow from one of the internal fluid flow paths, into the cavity and through the filter, and then out of the cavity via the port of the cassette cap. Alternatively, the cassette body may define an external slot which receives at least a portion of a filter. Such a filter includes two ports, with one of the ports in fluid communication with a cassette port of the cassette body to allow fluid flow between the cassette body and the filter.Type: ApplicationFiled: March 13, 2023Publication date: September 14, 2023Inventors: Benjamin E. Kusters, Mark J. Brierton
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Patent number: 11731371Abstract: A sterile connection device includes first and second carriages. The first carriage defines a first portion of a proximal slot and a first portion of a distal slot, while the second carriage defines second portions of the proximal and distal slots. A controller executes a sterile connection procedure in which a solid cutting blade is heated, followed by the heated blade being moved to a cutting position to cut sealed proximal and distal tubes received by the slots. The second carriage moves proximally or distally with respect to the first carriage so as to align the cut ends of the tubes. The heated blade then moves out of the cutting position, followed by the first carriage moving toward the second carriage so as to press the cut ends of the tubes into contact with each other so as to sterilely connect the cut ends and define a joined tube.Type: GrantFiled: January 21, 2022Date of Patent: August 22, 2023Assignee: Fenwal, Inc.Inventors: James Madsen, Kyungyoon Min, Mark J. Brierton, Tom Westberg
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Publication number: 20220410178Abstract: A prismatic reflector is provided for incorporation into a centrifugal separation chamber. The prismatic reflector is formed of a light-transmissive material and includes inner and outer walls and first and second end walls. The inner wall is configured to receive light traveling along an initial path and transmit the light to the first end wall, with the first end wall receiving the light transmitted through the inner wall and directing the light toward the second end wall in a direction that is angled with respect to the initial path. The second end wall receives the light from the first end wall and transmits the light out of the prismatic reflector. The initial path of the light may be in a direction toward a rotational axis of the centrifugal separation chamber, with the prismatic reflector redirecting the light into a direction substantially parallel to the rotational axis.Type: ApplicationFiled: August 31, 2022Publication date: December 29, 2022Inventors: Kyungyoon Min, Benjamin E. Kusters, Richard I. Brown, Mark J. Brierton
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Patent number: 11478755Abstract: A fluid processing system includes a disposable fluid circuit and reusable hardware configured to accept the disposable fluid circuit. The disposable fluid circuit includes a spinning membrane separator, first and second syringes, and a flow control cassette. The reusable hardware includes a spinning membrane separator drive coupled to the spinning membrane separator, first and second syringe pumps coupled to the first and second syringes respectively, a control cassette interface coupled to the flow control cassette, and at least one controller coupled to the spinning membrane separator drive, the first and second syringe pumps, and the control cassette interface. The controller is configured to selectively operate the drive, the first and second syringe pumps, and the interface to provide a procedure according to a protocol.Type: GrantFiled: August 15, 2019Date of Patent: October 25, 2022Assignee: Fenwal, Inc.Inventors: Christopher J. Wegener, Bret M. Olson, Carolyn Kos, Timothy Getschman, Mark J. Brierton, Robert A. Brown
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Patent number: 11465160Abstract: Systems and methods are provided for separating blood into two or more components. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit incorporated into a common case, which allows for fluid separation by two different methods. Depending on the separation procedure to be carried out, the fluid flow circuit paired with the blood separation device may include only one separation chamber configured to be mounted to the centrifugal separator or spinning membrane separator drive unit or two separation chambers, with one being mounted to the centrifugal separator and the other to the spinning membrane separator drive unit. The system may be used to separate and collect any combination of red blood cells, plasma, and platelets.Type: GrantFiled: September 15, 2017Date of Patent: October 11, 2022Assignee: Fenwal, Inc.Inventors: Kyungyoon Min, Benjamin E. Kusters, Richard I. Brown, Mark J. Brierton
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Publication number: 20220234303Abstract: A sterile connection device includes first and second carriages. The first carriage defines a first portion of a proximal slot and a first portion of a distal slot, while the second carriage defines second portions of the proximal and distal slots. A controller executes a sterile connection procedure in which a solid cutting blade is heated, followed by the heated blade being moved to a cutting position to cut sealed proximal and distal tubes received by the slots. The second carriage moves proximally or distally with respect to the first carriage so as to align the cut ends of the tubes. The heated blade then moves out of the cutting position, followed by the first carriage moving toward the second carriage so as to press the cut ends of the tubes into contact with each other so as to sterilely connect the cut ends and define a joined tube.Type: ApplicationFiled: January 21, 2022Publication date: July 28, 2022Inventors: James Madsen, Kyungyoon Min, Mark J. Brierton, Tom Westberg
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Patent number: 11389578Abstract: A fluid flow circuit assembly for a fluid processing device, comprising a housing having a plurality of openings, a separator disposed at least partially within the housing, and a plurality of flow paths communicating between an interior and an exterior of the housing via the plurality of openings, wherein the separator is disposed substantially at the center of the plurality of flow paths.Type: GrantFiled: October 13, 2016Date of Patent: July 19, 2022Assignee: Fenwal, Inc.Inventors: Benjamin E. Kusters, Mark J. Brierton
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Publication number: 20210046426Abstract: A fluid processing system includes a disposable fluid circuit and reusable hardware configured to accept the disposable fluid circuit. The disposable fluid circuit includes a spinning membrane separator, first and second syringes, and a flow control cassette. The reusable hardware includes a spinning membrane separator drive coupled to the spinning membrane separator, first and second syringe pumps coupled to the first and second syringes respectively, a control cassette interface coupled to the flow control cassette, and at least one controller coupled to the spinning membrane separator drive, the first and second syringe pumps, and the control cassette interface. The controller is configured to selectively operate the drive, the first and second syringe pumps, and the interface to provide a procedure according to a protocol.Type: ApplicationFiled: August 15, 2019Publication date: February 18, 2021Inventors: Christopher J. Wegener, Bret M. Olson, Carolyn Kos, Timothy Getschman, Mark J. Brierton, Robert A. Brown
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Patent number: 10865805Abstract: A disposable fluid pump is provided with a housing including first and second faces, with a sidewall extending between the first and second faces. The housing defines a chamber, with an inlet and an outlet in fluid communication with the chamber. An impeller is rotatably mounted within the chamber and includes a plurality of flexible vanes. Such a pump may be incorporated into a disposable fluid flow circuit that is adapted to be mounted on a durable hardware for processing a fluid. In such a fluid flow circuit, the fluid pump may be integrated into a cassette of the circuit or, alternatively, the inlet and outlet of the fluid pump may be directly connected to fluid flow conduits of the circuit.Type: GrantFiled: July 7, 2017Date of Patent: December 15, 2020Assignee: Fenwal, Inc.Inventors: Christopher J. Wegener, Mark J. Brierton
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Publication number: 20190201916Abstract: Systems and methods are provided for separating blood into two or more components. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit incorporated into a common case, which allows for fluid separation by two different methods. Depending on the separation procedure to be carried out, the fluid flow circuit paired with the blood separation device may include only one separation chamber configured to be mounted to the centrifugal separator or spinning membrane separator drive unit or two separation chambers, with one being mounted to the centrifugal separator and the other to the spinning membrane separator drive unit. The system may be used to separate and collect any combination of red blood cells, plasma, and platelets.Type: ApplicationFiled: September 15, 2017Publication date: July 4, 2019Inventors: Kyungyoon Min, Benjamin E. Kusters, Richard I. Brown, Mark J. Brierton
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Publication number: 20180311430Abstract: A fluid flow circuit assembly for a fluid processing device, comprising a housing having a plurality of openings, a separator disposed at least partially within the housing, and a plurality of flow paths communicating between an interior and an exterior of the housing via the plurality of openings, wherein the separator is disposed substantially at the center of the plurality of flow paths.Type: ApplicationFiled: October 13, 2016Publication date: November 1, 2018Inventors: Benjamin E. Kusters, Mark J. Brierton
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Publication number: 20180010612Abstract: A disposable fluid pump is provided with a housing including first and second faces, with a sidewall extending between the first and second faces. The housing defines a chamber, with an inlet and an outlet in fluid communication with the chamber. An impeller is rotatably mounted within the chamber and includes a plurality of flexible vanes. Such a pump may be incorporated into a disposable fluid flow circuit that is adapted to be mounted on a durable hardware for processing a fluid. In such a fluid flow circuit, the fluid pump may be integrated into a cassette of the circuit or, alternatively, the inlet and outlet of the fluid pump may be directly connected to fluid flow conduits of the circuit.Type: ApplicationFiled: July 7, 2017Publication date: January 11, 2018Inventors: Christopher J. Wegener, Mark J. Brierton
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Patent number: 9421318Abstract: The present disclosure relates generally to systems for processing a unit of whole blood into its components while the unit is still in the centrifuge. The system comprises a container holding whole blood and one or more satellite bags or containers that are installed into a holder, which is then inserted into a bucket of the centrifuge. Tubes interconnect the containers, one or more of which are preferably installed into clamping mechanisms resident in the holder. The holder further preferably includes sensing means, such as optical sensors, to sense the location of the interfaces between the separated layers of the whole blood that result from rotation of the centrifuge.Type: GrantFiled: October 24, 2012Date of Patent: August 23, 2016Assignee: Fenwal, Inc.Inventors: Marc N. Weasler, Richard I. Brown, Sean Ford, Mark J. Brierton
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Patent number: 9408961Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.Type: GrantFiled: March 9, 2012Date of Patent: August 9, 2016Assignee: Fenwal, Inc.Inventors: Christopher J. Wegener, Kyungyoon Min, Laurent Forcioli, Mark J. Brierton, Daniel R. Boggs
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Patent number: 9381291Abstract: A membrane separation device for use in blood processing procedures is disclosed. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.Type: GrantFiled: March 9, 2012Date of Patent: July 5, 2016Assignee: Fenwal, Inc.Inventors: Daniel R. Boggs, Mark J. Brierton, Benjamin E. Kusters, Kyungyoon Min, Christopher J. Wegener
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Publication number: 20140066281Abstract: The present disclosure relates generally to systems for processing a unit of whole blood into its components while the unit is still in the centrifuge. The system comprises a container holding whole blood and one or more satellite bags or containers that are installed into a holder, which is then inserted into a bucket of the centrifuge. Tubes interconnect the containers, one or more of which are preferably installed into clamping mechanisms resident in the holder. The holder further preferably includes sensing means, such as optical sensors, to sense the location of the interfaces between the separated layers of the whole blood that result from rotation of the centrifuge.Type: ApplicationFiled: October 24, 2012Publication date: March 6, 2014Inventors: Marc N. Weasler, Richard I. Brown, Sean Ford, Mark J. Brierton
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Publication number: 20140010738Abstract: A membrane separation device for use in blood processing procedures is disclosed. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.Type: ApplicationFiled: March 9, 2012Publication date: January 9, 2014Applicant: FENWAL INC.Inventors: Daniel R. Boggs, Mark J. Brierton, Benjamin E. Kusters, Kyungyoon Min, Christopher J. Wegener
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Publication number: 20130341291Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.Type: ApplicationFiled: March 9, 2012Publication date: December 26, 2013Applicant: FENWAL, INC.Inventors: Christopher J. Wegener, Kyungyoon Min, Laurent Forcioli, Mark J. Brierton, Daniel R. Boggs
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Publication number: 20110086752Abstract: A blood separation chamber for rotation about an axis comprises a low-G wall and a high-G wall extending about the axis in a spaced apart relationship to define between them a separation channel. The separation channel includes axially spaced first and second ends. The first end of the separation channel defines at least one generally arcuate recessed region and at least one radial wall within the recessed region sized and positioned so as to aid in balancing the blood separation chamber during rotation about the axis.Type: ApplicationFiled: October 8, 2009Publication date: April 14, 2011Inventor: Mark J. Brierton
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Patent number: 6409696Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: October 10, 1997Date of Patent: June 25, 2002Assignee: Gambro, Inc.Inventors: Coy Toavs, John J. Kappus, Mark J. Brierton, David R. Shouldice, Jeffrey J. Blakeslee