Patents by Inventor Mark J. Cartwright
Mark J. Cartwright has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11968268Abstract: An audio session management method may involve: determining, by an audio session manager, one or more first media engine capabilities of a first media engine of a first smart audio device, the first media engine being configured for managing one or more audio media streams received by the first smart audio device and for performing first smart audio device signal processing for the one or more audio media streams according to a first media engine sample clock; receiving, by the audio session manager and via a first application communication link, first application control signals from the first application; and controlling the first smart audio device according to the first media engine capabilities, by the audio session manager, via first audio session management control signals transmitted to the first smart audio device via a first smart audio device communication link and without reference to the first media engine sample clock.Type: GrantFiled: July 28, 2020Date of Patent: April 23, 2024Assignees: Dolby Laboratories Licensing Corporation, Dolby International ABInventors: Glenn N. Dickins, Mark R. P. Thomas, Alan J. Seefeldt, Joshua B. Lando, Daniel Arteaga, Carlos Medaglia Dyonisio, David Gunawan, Richard J. Cartwright, Christopher Graham Hines
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Publication number: 20240108709Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.Type: ApplicationFiled: March 20, 2023Publication date: April 4, 2024Applicant: President and Fellows of Harvard CollegeInventors: Michael Super, Edward J. Doherty, Mark Joseph Cartwright, Des White, Alexander Stafford, Omar Abdel-Rahman Ali, Amanda Graveline, Donald E. Ingber, David J. Mooney, Benjamin Seiler
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Patent number: 11795212Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: GrantFiled: November 10, 2020Date of Patent: October 24, 2023Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. Ingber, Michael Super, Jeffrey Charles Way, Mark J. Cartwright, Julia B. Berthet, Dinah R. Super, Martin Rottman, Alexander L. Watters
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Patent number: 11718651Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.Type: GrantFiled: May 12, 2021Date of Patent: August 8, 2023Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander L. Watters, Donald E. Ingber, Mark J. Cartwright, Michael Super, Martin Rottman, Evangelia Murray, Brendon Dusel
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Publication number: 20220074936Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.Type: ApplicationFiled: November 17, 2021Publication date: March 10, 2022Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Mark J. CARTWRIGHT, Nazita GAMINI, Donald E. INGBER, Martin M. ROTTMAN, Michael SUPER, Julie A. TOMOLONIS, Karen A. SINCLAIR
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Patent number: 11209432Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.Type: GrantFiled: June 11, 2020Date of Patent: December 28, 2021Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Mark J. Cartwright, Nazita Gamini, Donald E. Ingber, Martin Rottman, Michael Super, Julie A. Tomolonis, Karen A. Sinclair
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Publication number: 20210277079Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.Type: ApplicationFiled: May 12, 2021Publication date: September 9, 2021Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander L. WATTERS, Donald E. INGBER, Mark J. CARTWRIGHT, Michael SUPER, Martin ROTTMAN, Evangelia MURRAY, Brendon DUSEL
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Patent number: 11034744Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.Type: GrantFiled: October 31, 2019Date of Patent: June 15, 2021Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander L. Watters, Donald E. Ingber, Mark J. Cartwright, Michael Super, Martin Rottman, Evangelia Murray, Brendon Dusel
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Publication number: 20210155677Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: ApplicationFiled: November 10, 2020Publication date: May 27, 2021Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. INGBER, Michael SUPER, Jeffrey Charles WAY, Mark J. CARTWRIGHT, Julia B. BERTHET, Dinah R. SUPER, Martin ROTTMAN, Alexander L. WATTERS
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Patent number: 10865235Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: GrantFiled: November 14, 2019Date of Patent: December 15, 2020Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. Ingber, Michael Super, Jeffrey Charles Way, Mark J. Cartwright, Julia B. Berthet, Dinah R. Super, Martin Rottman, Alexander L. Watters
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Publication number: 20200300854Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.Type: ApplicationFiled: June 11, 2020Publication date: September 24, 2020Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Mark J. CARTWRIGHT, Nazita GAMINI, Donald E. INGBER, Martin ROTTMAN, Michael SUPER, Julie A. TOMOLONIS, Karen A. SINCLAIR
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Publication number: 20200239552Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: ApplicationFiled: November 14, 2019Publication date: July 30, 2020Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. INGBER, Michael SUPER, Jeffrey Charles WAY, Mark J. CARTWRIGHT, Julia B. BERTHET, Dinah R. SUPER, Martin ROTTMAN, Alexander L. WATTERS
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Patent number: 10718766Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.Type: GrantFiled: August 4, 2017Date of Patent: July 21, 2020Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Mark J. Cartwright, Nazita Gamini, Donald E. Ingber, Martin Rottman, Michael Super, Julie A. Tomolonis, Karen A. Sinclair
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Publication number: 20200103402Abstract: Methods, compositions, kits and systems for detecting and/or capturing a target entity in a sample. In particular, the methods, compositions and kits described herein can be used for pre-treatment of target-binding agents with a blocking agent to reduce non-target binding in a complex matrix (e.g., blood). Methods and compositions for detecting and/or capturing a microbe in a test sample, including bodily fluids such as blood and tissues of a subject, food, water, and environmental surfaces are also disclosed.Type: ApplicationFiled: December 13, 2019Publication date: April 2, 2020Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Michael SUPER, Mark J. CARTWRIGHT, Martin M. ROTTMAN, Julie A. TOMOLONIS
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Publication number: 20200079828Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.Type: ApplicationFiled: October 31, 2019Publication date: March 12, 2020Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander L. WATTERS, Donald E. INGBER, Mark J. CARTWRIGHT, Michael SUPER, Martin ROTTMAN, Evangelia MURRAY, Brendon DUSEL
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Patent number: 10551379Abstract: Methods, compositions, kits and systems for detecting and/or capturing a target entity in a sample are disclosed. In particular, the methods, compositions and kits described herein can be used for pretreatment of target-binding agents with a blocking agent to reduce non-target binding in a complex matrix (e.g., blood). Methods and compositions for detecting and/or capturing a microbe in a test sample, including bodily fluids such as blood and tissues of a subject, food, water, and environmental surfaces are also disclosed.Type: GrantFiled: March 14, 2014Date of Patent: February 4, 2020Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Michael Super, Mark J. Cartwright, Martin M. Rottman, Julie A. Tomolonis
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Patent number: 10526399Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: GrantFiled: January 25, 2017Date of Patent: January 7, 2020Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. Ingber, Michael Super, Jeffrey Charles Way, Mark J. Cartwright, Julia B. Berthet, Dinah R. Super, Martin Rottman, Alexander L. Watters
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Patent number: 10513546Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.Type: GrantFiled: December 18, 2014Date of Patent: December 24, 2019Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander L. Watters, Donald E. Ingber, Mark J. Cartwright, Michael Super, Martin Rottman, Evangelia Murray, Brendon Dusel
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Publication number: 20170362307Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: ApplicationFiled: January 25, 2017Publication date: December 21, 2017Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. INGBER, Michael SUPER, Jeffrey Charles WAY, Mark J. CARTWRIGHT, Julia B. BERTHET, Dinah R. SUPER, Martin M. ROTTMAN, Alexander WATTERS
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Publication number: 20170350885Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.Type: ApplicationFiled: August 4, 2017Publication date: December 7, 2017Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Mark J. CARTWRIGHT, Nazita GAMINI, Donald E. INGBER, Martin ROTTMAN, Michael SUPER, Julie A. TOMOLONIS, Karen A. SINCLAIR