Patents by Inventor Mark J. Henderson

Mark J. Henderson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FUSED DIAZEPINES AS AGONISTS OF THE INSULIN-LIKE 3 (INSL3) PEPTIDE RECEPTOR RXFP2 AND METHODS OF USE THEREOF
    Publication number: 20250134907
    Abstract: Disclosed is a compound of formula (I), in which R1, R2, R3, R4, R5, X1, X2, X3, X4, and X5 are described herein. The small molecule compounds of formula (I) activate the functional activity of relaxin family peptide receptor 2 (RXFP2), thereby providing therapeutic treatments for a variety of disorders, such as a bone disorder, hypogonadism, cryptorchidism, polycystic ovary syndrome, cancer, infertility, or an ocular wound.
    Type: Application
    Filed: January 31, 2023
    Publication date: May 1, 2025
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, The Florida International University Board of Trustees
    Inventors: Juan J. Marugan, Noel T. Southall, Marc Ferrer, Mark J. Henderson, Kenneth J. Wilson, Alexander I. Agoulnik, Courtney B. Myhr, Maria Esteban-Lopez, Elena Barnaeva, Xin Hu, Wenjuan Ye, Irina Agoulnik
  • METHODS AND SYSTEMS FOR ANALYZING TARGET ENGAGEMENT DATA FROM BIOLOGICAL ASSAYS
    Publication number: 20250130234
    Abstract: The disclosure provides methods for carrying out Real Time Cellular Thermal Shift Assays (RT-CETSA). Also provided are molecular constructs and protein constructs for use in such assays and devices suitable for carrying out such assays. Also provided are non-parametric methods for analyzing data from RT-CETSA and other biological target engagement assays.
    Type: Application
    Filed: December 21, 2022
    Publication date: April 24, 2025
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Michael H. Ronzetti, Mark J. Henderson, Tino W. Sanchez, Samuel G. Michael, Ty C. Voss, Bolormaa Baljinnyam, Anton Simeonov
  • REAL-TIME CELLULAR THERMAL SHIFT ASSAY (RT-CETSA) FOR RESEARCH AND DRUG DISCOVERY
    Publication number: 20230257756
    Abstract: The disclosure provides methods for carrying out Real Time Cellular Thermal Shift Assays (RT-CETSA). Also provided are molecular constructs and protein constructs for use in such assays and devices suitable for carrying out such assays.
    Type: Application
    Filed: August 9, 2021
    Publication date: August 17, 2023
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Mark J. Henderson, Michael H. Ronzetti, Bolormaa Baljinnyam, Tino W. Sanchez, Samuel G. Michael, Ashley E. Owens, Anton Simeonov
  • System and method for producing bonded fiber/cellulose products
    Patent number: 8795470
    Abstract: A system and method of producing both loose cellulose insulation and bonded fiber/cellulose insulation products utilizing shredded paper particles, including making shredded paper particles in a shredded paper particle line and diverting a portion of the shredded paper particles to a bonded fiber/cellulose product line whereby the shredded paper particle line forms an in-process production and delivery of shredded paper particles to the bonded fiber/cellulose product line. Moisture is added to the shredded paper particles at the bonded fiber/cellulose product line, and bonded fiber/cellulose insulation products are produced with the bonded fiber/cellulose product line from the diverted portion of shredded paper particles and loose cellulose insulation is produced from shredded paper particles that are not diverted from the shredded paper particle line.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: August 5, 2014
    Inventors: Mark J. Henderson, Akiva Pinto
  • SYSTEM AND METHOD FOR PRODUCING BONDED FIBER/CELLULOSE PRODUCTS
    Publication number: 20130256940
    Abstract: A system and method of producing both loose cellulose insulation and bonded fiber/cellulose insulation products utilizing shredded paper particles, including making shredded paper particles in a shredded paper particle line and diverting a portion of the shredded paper particles to a bonded fiber/cellulose product line whereby the shredded paper particle line forms an in-process production and delivery of shredded paper particles to the bonded fiber/cellulose product line. Moisture is added to the shredded paper particles at the bonded fiber/cellulose product line, and bonded fiber/cellulose insulation products are produced with the bonded fiber/cellulose product line from the diverted portion of shredded paper particles and loose cellulose insulation is produced from shredded paper particles that are not diverted from the shredded paper particle line.
    Type: Application
    Filed: May 28, 2013
    Publication date: October 3, 2013
    Inventors: Mark J. Henderson, Akiva Pinto
  • System and method for producing bonded fiber/cellulose products
    Patent number: 8454795
    Abstract: A system for forming bonded fiber/cellulose products includes a shredded paper particle manufacturing line producing shredded paper particle-based products, such as insulation, a bonded fiber/cellulose product line, and a collector for collecting a portion of the shredded paper particles generated by the shredded paper particle line for the bonded fiber/cellulose product line.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: June 4, 2013
    Inventors: Mark J. Henderson, Akiva Pinto