Patents by Inventor Mark J. Keegan
Mark J. Keegan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200390881Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise immunomodulatory agents and antigens that are differentially released from the synthetic nanocarriers.Type: ApplicationFiled: January 27, 2020Publication date: December 17, 2020Applicant: Selecta Biosciences, Inc.Inventors: Grayson B. Lipford, Charles Zepp, Yun Gao, Mark J. Keegan, Sam Baldwin, Fen-ni Fu, Lloyd Johnston
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Publication number: 20180256709Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.Type: ApplicationFiled: February 5, 2018Publication date: September 13, 2018Applicant: Selecta Biosciences, Inc.Inventors: Charles Zepp, Grayson B. Lipford, Yun Gao, Lloyd Johnston, Fen-ni Fu, Mark J. Keegan, Sam Baldwin
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Patent number: 9884112Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.Type: GrantFiled: March 13, 2015Date of Patent: February 6, 2018Assignee: Selecta Biosciences, Inc.Inventors: Charles Zepp, Grayson B. Lipford, Yun Gao, Lloyd Johnston, Fen-ni Fu, Mark J. Keegan, Sam Baldwin
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Publication number: 20150328300Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.Type: ApplicationFiled: March 13, 2015Publication date: November 19, 2015Applicant: Selecta Biosciences, Inc.Inventors: Charles Zepp, Grayson B. Lipford, Yun Gao, Lloyd Johnston, Fen-ni Fu, Mark J. Keegan, Sam Baldwin
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Patent number: 9006254Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.Type: GrantFiled: December 23, 2013Date of Patent: April 14, 2015Assignee: Selecta Biosciences, Inc.Inventors: Charles Zepp, Grayson B. Lipford, Yun Gao, Lloyd Johnston, Fen-ni Fu, Mark J. Keegan, Sam Baldwin
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Publication number: 20140242173Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.Type: ApplicationFiled: May 8, 2014Publication date: August 28, 2014Applicant: Selecta Biosciences, Inc.Inventors: Charles Zepp, Yun Gao, Mark J. Keegan, Sam Baldwin, Fen-ni Fu, Lloyd Johnston, Grayson B. Lipford
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Publication number: 20140193453Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.Type: ApplicationFiled: December 23, 2013Publication date: July 10, 2014Applicant: SELECTA BIOSCIENCES, INC.Inventors: CHARLES ZEPP, GRAYSON B. LIPFORD, YUN GAO, LLOYD JOHNSTON, FEN-NI FU, MARK J. KEEGAN, SAM BALDWIN
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Publication number: 20140030344Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.Type: ApplicationFiled: July 22, 2013Publication date: January 30, 2014Applicant: Selecta Biosciences, Inc.Inventors: Charles Zepp, Yun Gao, Mark J. Keegan, Sam Baldwin, Fen-ni Fu, Lloyd Johnston, Grayson B. Lipford
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Patent number: 8629151Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.Type: GrantFiled: May 26, 2010Date of Patent: January 14, 2014Assignee: Selecta Biosciences, Inc.Inventors: Charles Zepp, Grayson B. Lipford, Yun Gao, Lloyd Johnston, Fen-ni Fu, Mark J. Keegan, Sam Baldwin
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Publication number: 20110272836Abstract: Vessels, including non-symmetric vessels for mixing fluids, are disclosed. In one aspect, the vessel is one that has a non-rotationally-symmetric interior surface. For example, the vessel may have an oblique frustoconical shape. At least a portion of the mixing vessel may have horizontal cross-sections having varying area, in some embodiments. The vessel may be formed from any suitable material, e.g., glass, plastic, or stainless steel. Such vessels may be used, according to certain embodiments, to create single, double or other multiple emulsions, for example, by exposing liquids or fluids contained therein to relatively high shear rates. In some cases, the vessel may be designed to be pharmaceutical-grade and/or meet ASME Bioprocessing Equipment (ASME-BPE) standards. For instance, the vessel may be used under conditions where the vessel is sterile, and/or the vessel may have a polished internal surface.Type: ApplicationFiled: April 12, 2011Publication date: November 10, 2011Applicant: Selecta Biosciences, Inc.Inventors: MARK J. KEEGAN, Donna L. Kessel
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Publication number: 20110262491Abstract: This invention relates, in part, to methods of using emulsions for making synthetic nanocarriers and the synthetic nanocarriers formed by such methods.Type: ApplicationFiled: April 12, 2011Publication date: October 27, 2011Applicant: Selecta Biosciences, Inc.Inventors: Mark J. Keegan, Christopher E. Mooney
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Publication number: 20110027217Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.Type: ApplicationFiled: May 26, 2010Publication date: February 3, 2011Applicant: SELECTA BIOSCIENCES, INC.Inventors: CHARLES ZEPP, GRAYSON B. LIPFORD, YUN GAO, LLOYD JOHNSTON, FEN-NI FU FU, MARK J. KEEGAN, SAM BALDWIN
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Publication number: 20110020388Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.Type: ApplicationFiled: May 26, 2010Publication date: January 27, 2011Applicant: Selecta Biosciences, Inc.Inventors: CHARLES ZEPP, Yun Gao, Mark J. Keegan, Sam Baldwin, Fen-ni Fu, Lloyd Johnston, Grayson B. Lipford
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Publication number: 20100303850Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise immunomodulatory agents and antigens that are differentially released from the synthetic nanocarriers.Type: ApplicationFiled: May 26, 2010Publication date: December 2, 2010Applicant: Selecta Biosciences, Inc.Inventors: Grayson B. Lipford, Charles Zepp, Yun Gao, Mark J. Keegan, Sam Baldwin, Fen-ni Fu, Llyod Johnston
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Patent number: 6560897Abstract: Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield. Te secondary drying apparatus can include multiple secondary apparati, which are independently controlled for temperature and/or have different dimensions (cross-sectional areas and/or lengths), to allow for optimization of drying conditions.Type: GrantFiled: October 26, 2001Date of Patent: May 13, 2003Assignee: Acusphere, Inc.Inventors: Donald E. Chickering, III, Mark J. Keegan, Greg Randall, Howard Bernstein, Julie Straub
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Publication number: 20030037459Abstract: Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield. Te secondary drying apparatus can include multiple secondary apparati, which are independently controlled for temperature and/or have different dimensions (cross-sectional areas and/or lengths), to allow for optimization of drying conditions.Type: ApplicationFiled: October 26, 2001Publication date: February 27, 2003Applicant: Acusphere, Inc.Inventors: Donald E. Chickering, Mark J. Keegan, Greg Randall, Howard Bernstein, Julie Straub
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Patent number: 6308434Abstract: Improved spray drying methods of have been developed. The spray drying method includes use of a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield. The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses.Type: GrantFiled: January 9, 2001Date of Patent: October 30, 2001Assignee: Acusphere, Inc.Inventors: Donald E. Chickering, III, Mark J. Keegan, Greg Randall, Howard Bernstein, Julie Straub
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Publication number: 20010027614Abstract: Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield. The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses.Type: ApplicationFiled: January 9, 2001Publication date: October 11, 2001Inventors: Donald E. Chickering, Mark J. Keegan, Greg Randall, Howard Bernstein, Julie Straub