Abstract: An apparatus includes a housing, a medicament container and an actuator. The actuator includes a release member and an energy storage member having a first position and a second position. In the first position, the energy storage member has a first potential energy. In the second position the energy storage member has a second potential energy. The energy storage member is configured to convert a portion of the first potential energy into kinetic energy when moved from the first position to the second position to move the medicament container within the housing. The energy storage member has a longitudinal axis offset from a longitudinal axis of the medicament container. The release member is configured to selectively deploy the energy storage member from its first position to its second position.

Abstract: Apparatuses for automatic medicament injection and methods for manufacturing automatic medicament injectors are described herein. In some embodiments, an apparatus includes a housing, a needle, an energy storage member, an actuator, a locking member, and a needle guard. The needle is configured to move between a first position and a second position. In its first position, the needle is contained within the housing. In its second position, at least a portion of the needle extends from the housing. The energy storage member has a first configuration and a second configuration and is configured to produce a force when moving between its first configuration and its second configuration to move the needle from its first position to its second position. The actuator is configured to move the energy storage member from its first configuration to its second configuration.

Abstract: Medicament delivery devices are described herein. In some embodiments, an apparatus includes a medicament delivery device and an electronic circuit system. The medicament delivery device includes a housing, a medicament container, and a medicament delivery member. The electronic circuit system is coupled to the housing and includes an audible output device and a cover. The housing of the medicament delivery device and the cover of the electronic circuit system collectively define an acoustic enclosure. The audible output device is configured to be disposed within the acoustic enclosure.

Abstract: An apparatus includes a housing, a medicament container and an actuator. The actuator includes a release member and an energy storage member having a first position and a second position. In the first position, the energy storage member has a first potential energy. In the second position the energy storage member has a second potential energy. The energy storage member is configured to convert a portion of the first potential energy into kinetic energy when moved from the first position to the second position to move the medicament container within the housing. The energy storage member has a longitudinal axis offset from a longitudinal axis of the medicament container. The release member is configured to selectively deploy the energy storage member from its first position to its second position.

Abstract: Apparatuses for automatic medicament injection and methods for manufacturing automatic medicament injectors are described herein. In some embodiments, an apparatus includes a housing, a needle, an energy storage member, an actuator, a locking member, and a needle guard. The needle is configured to move between a first position and a second position. In its first position, the needle is contained within the housing. In its second position, at least a portion of the needle extends from the housing. The energy storage member has a first configuration and a second configuration and is configured to produce a force when moving between its first configuration and its second configuration to move the needle from its first position to its second position. The actuator is configured to move the energy storage member from its first configuration to its second configuration.

Abstract: A system includes a medicament delivery device and a container configured to receive at least a portion of the medicament delivery device. The medicament delivery device includes an actuator and a first electronic circuit system. The actuator is configured to initiate delivery of a medicament into a body when the actuator is moved from a first position to a second position. The first electronic circuit system is configured to output a first electronic signal when the actuator is moved from the first position to the second position. The container includes a second electronic circuit system configured to receive the first electronic signal. The second electronic circuit system is configured to output a second electronic signal associated with the first electronic signal.

Abstract: Certain exemplary embodiments comprise can comprise an auto-injector, which can comprise: a vial configured to store and/or contain an injectable medicament, the vial defining a vial longitudinal axis, and a housing comprising the vial. In various embodiments, the injectable medicament can be a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, and/or nutritional supplement that is substantially ready for injection.

Abstract: Medicament delivery devices are described herein. In some embodiments, an apparatus includes a medical injector and an electronic circuit system. The medical injector includes a housing, a medicament container, and a medicament delivery member. The housing defines a first region and a second region. The first region includes the medicament container and is physically isolated from the second region. The electronic circuit system is configured to be disposed within the second region defined by the housing. The electronic circuit system is configured to output an electronic output associated with a use of the medical injector.

Abstract: An apparatus includes a housing and a medicament container disposed within the housing. The medicament container includes a first plunger and a second plunger, each disposed therein. The medicament container has a first configuration and a second configuration. In the first configuration, the first plunger is disposed in a first position and the second plunger is disposed in a second position spaced apart from the first position by a first distance. Accordingly, a first portion is defined between the first plunger and the second plunger. A second portion is defined between the second plunger and a distal end of the medicament container. In the second configuration, the first plunger remains in the first position and the second plunger is disposed in a third position spaced apart from the first position by a second distance, such that a volume of the second portion is greater when the medicament container is in the second configuration than when in the first configuration.

Abstract: A sensor for biopotential measurements is designed to detect low voltage electrical signals on a subject's skin surface. A plurality of soft elastomeric bristles are arranged about the surface of the skin. Various bristles contain a wick, made of polyolefin, polyester or nylon, extending along its center axis with one end protruding from the bristle and another end in contact with a fluid reservoir. The wick is saturated with an electrically conductive liquid, such as a salt solution. The solution may contain a surfactant. The rheological properties of the electrically conductive liquid are optimized for predictable flow through the wick onto the skin surface. An electrode is positioned in the vicinity of the wick and the reservoir. Alternatively, a sensor comprises a plurality of hollow, soft elastomeric bristles filled with a hydrogel. An electrically conductive cap provides the electrical contact between the hydrogel and the electrical circuit.

Abstract: A sensor for biopotential measurements is designed to detect low voltage electrical signals on a subject's skin surface. A plurality of soft elastomeric bristles are arranged about the surface of the skin. Various bristles contain a wick, made of polyolefin, polyester or nylon, extending along its center axis with one end protruding from the bristle and another end in contact with a fluid reservoir. The wick is saturated with an electrically conductive liquid, such as a salt solution. The solution may contain a surfactant. The rheological properties of the electrically conductive liquid are optimized for predictable flow through the wick onto the skin surface. An electrode is positioned in the vicinity of the wick and the reservoir. Alternatively, a sensor comprises a plurality of hollow, soft elastomeric bristles filled with a hydrogel. An electrically conductive cap provides the electrical contact between the hydrogel and the electrical circuit.

Abstract: A sensor for biopotential measurements is designed to detect low voltage electrical signals on a subject's skin surface. A plurality of soft elastomeric bristles are arranged about the surface of the skin. Various bristles contain a wick, made of polyolefin, polyester or nylon, extending along its center axis with one end protruding from the bristle and another end in contact with a fluid reservoir. The wick is saturated with an electrically conductive liquid, such as a salt solution. The solution may contain a surfactant. The surface properties of the electrically conductive liquid and wick are optimized for predictable flow through the wick onto the skin surface. An electrode is positioned in the vicinity of the wick and the reservoir.

Abstract: A subcutaneously implantable injection port includes an elastomeric outer housing which encloses an easily assemblage multi-piece rigid base structure. An injection chamber is defined between an upper septum, formed integrally with the elastomeric outer housing, and the underlying base structure. The outer housing includes an upper dome and a lower reinforced sheet. The septum, which is formed integrally with the upper dome, includes a septum flange which is compressed, interiorly of the outer housing, between two base members. A filter extends across the injection chamber dividing it into upper and lower portions. A needle guard, provided by one of the base components, prevents contact between a needle inserted into the injection chamber and the filter. An outlet connector integrally formed with one of the base components extends through the outer housing for connecting a catheter or the like, with the lower portion of the injection chamber.

Abstract: A subcutaneously implantable medication infusion device includes a variable capacity reservoir for receiving and storing fluid medication for delivery to a catheter which directs the medication to a specific infusion location in the body. A control assembly is interposed between the reservoir and the catheter to facilitate and control the transfer of the medication from the reservoir to the catheter in a safe and efficient manner. The control assembly includes a self-recharging pump and a normally closed valve, both of which are manually actuable by percutaneous pressure when subcutaneously implanted, and a one-way valve positioned within a primary fluid conduit between the pump and the normally closed valve. The control assembly is constructed to permit the infusion of a measured bolus of medication on demand through manual percutaneous manipulation of the control assembly.