Patents by Inventor Mark J Nelson
Mark J Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240147631Abstract: Devices, systems, and methods for making and using highly sustainable circuit assemblies are disclosed herein. In various aspects, the highly sustainable circuit assembly includes a substrate layer; and a pattern of contact points supported by the substrate layer. The pattern of contact points can be configured to correspond to at least one terminal of an electrical component. The pattern of contact points can include a deformable conductive material. The deformable conductive material can be a non-hazardous, readily reclaimable, readily recyclable material.Type: ApplicationFiled: February 25, 2022Publication date: May 2, 2024Applicant: Liquid Wire, LLCInventors: Jorge E. Carbo, JR., Sai Srinivas Desabathina, Michael Adventure Hopkins, Charles J. Kinzel, Mark S. Kruskopf, Jesse Michael Martinez, Katherine M. Nelson, Taylor V. Neumann, Trevor Antonio Rivera, Mark William Ronay, Michael Jasper Wallans, Austin Michael Clarke
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Publication number: 20210071134Abstract: A fermentation broth which includes a microbial cell which has been subjected to a condition under which the activity an endogenous transporter for 2? fucosyllactose is increased. Also provided are methods for increasing export of 2? fucosyllactose from a microbial cell, methods for identifying an endogenous yeast transporter of 2? fucosyllactose, and microbial cells genetically engineered to increase the activity of an endogenous transporter of 2? fucosyllactose.Type: ApplicationFiled: April 23, 2018Publication date: March 11, 2021Inventors: Lisa A. LAFFEND, Mark J. NELSON, Lori Ann MAGGIO-HALL
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Publication number: 20190323053Abstract: A fermentation broth which includes a microbial cell which has been subjected to a condition under which the activity an endogenous transporter for 2? fucosyllactose is increased. Also provided are methods for increasing export of 2? fucosyllactose from a microbial cell, methods for identifying an endogenous yeast transporter of 2? fucosyllactose, and microbial cells genetically engineered to increase the activity of an endogenous transporter of 2? fucosyllactose.Type: ApplicationFiled: April 23, 2018Publication date: October 24, 2019Inventors: Lisa A LAFFEND, Mark J. Nelson, Lori Ann Maggio-Hall
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Patent number: 9944954Abstract: Provided herein are glycerol-3-phosphate dehydrogenase (GPD) enzymes with increased KM for NADH and GPD enzymes with substantially the same affinity for NADH and NADPH and/or are feedback inhibited by glycerol-3-phosphate. Also provided herein are recombinant microorganisms comprising a heterologous gene encoding GPD and a deletion or disruption in an endogenous gene encoding GPD. Also provided are recombinant microorganisms comprising a heterologous gene encoding GPD and a butanol biosynthetic pathway. Further provided are methods of producing butanol comprising providing the recombinant microorganisms described herein and contacting the recombinant microorganism with at least one fermentable carbon substrate under conditions wherein butanol is produced.Type: GrantFiled: August 4, 2016Date of Patent: April 17, 2018Assignee: Butamax Advanced Biofuels LLCInventors: Ritu Bhalla, Gopal K. Chotani, Michael Dauner, Mark J. Nelson, Daniel P. O'Keefe, Caroline M. Peres, Jahnavi Chandra Prasad, Jean-Francois Tomb
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Patent number: 9790521Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.Type: GrantFiled: March 23, 2012Date of Patent: October 17, 2017Assignee: Butamax Advanced Biofuels LLCInventors: Larry Cameron Anthony, Hongxian He, Lixuan Lisa Huang, Daniel P. Okeefe, Arthur Leo Kruckeberg, Yougen Li, Lori Ann Maggio-Hall, Jessica McElvain, Mark J. Nelson, Ranjan Patnaik, Steven Cary Rothman
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Publication number: 20170275652Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.Type: ApplicationFiled: April 3, 2017Publication date: September 28, 2017Inventors: Larry Cameron Anthony, Hongxian HE, Lixuan Lisa HUANG, Daniel P. O'KEEFE, Arthur Leo KRUCKBERG, Yougen LI, Lori Ann MAGGIO-HALL, Jessica MCELVAIN, Mark J. NELSON, Ranjan PATNAIK, Steven Cary ROTHMAN
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Publication number: 20160376613Abstract: Provided herein are glycerol-3-phosphate dehydrogenase (GPD) enzymes with increased KM for NADH and GPD enzymes with substantially the same affinity for NADH and NADPH and/or are feedback inhibited by glycerol-3-phosphate. Also provided herein are recombinant microorganisms comprising a heterologous gene encoding GPD and a deletion or disruption in an endogenous gene encoding GPD. Also provided are recombinant microorganisms comprising a heterologous gene encoding GPD and a butanol biosynthetic pathway. Further provided are methods of producing butanol comprising providing the recombinant microorganisms described herein and contacting the recombinant microorganism with at least one fermentable carbon substrate under conditions wherein butanol is produced.Type: ApplicationFiled: August 4, 2016Publication date: December 29, 2016Inventors: RITU BHALLA, GOPAL K. CHOTANI, MICHAEL DAUNER, MARK J. NELSON, DANIEL P. O'KEEFE, CAROLINE M. PERES, JAHNAVI CHANDRA PRASAD, JEAN-FRANCOIS TOMB
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Patent number: 9441250Abstract: Provided herein are glycerol-3-phosphate dehydrogenase (GPD) enzymes with increased KM for NADH and GPD enzymes with substantially the same affinity for NADH and NADPH and/or are feedback inhibited by glycerol-3-phosphate. Also provided herein are recombinant microorganisms comprising a heterologous gene encoding GPD and a deletion or disruption in an endogenous gene encoding GPD. Also provided are recombinant microorganisms comprising a heterologous gene encoding GPD and a butanol biosynthetic pathway. Further provided are methods of producing butanol comprising providing the recombinant microorganisms described herein and contacting the recombinant microorganism with at least one fermentable carbon substrate under conditions wherein butanol is produced.Type: GrantFiled: March 13, 2014Date of Patent: September 13, 2016Assignee: Butamax Advanced Biofuels LLCInventors: Ritu Bhalla, Gopal K Chotani, Michael Dauner, Mark J Nelson, Daniel P O'Keefe, Caroline M Peres, Jahnavi Chandra Prasad, Jean-Francois Tomb
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Patent number: 9422581Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.Type: GrantFiled: March 15, 2013Date of Patent: August 23, 2016Assignee: Butamax Advanced Biofuels LLCInventors: Larry Cameron Anthony, Hongxian He, Lixuan Lisa Huang, Daniel P. Okeefe, Arthur Leo Kruckeberg, Yougen Li, Lori Ann Maggio-Hall, Jessica McElvain, Mark J. Nelson, Ranjan Patnaik, Steven Cary Rothman
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Patent number: 9422582Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.Type: GrantFiled: March 15, 2013Date of Patent: August 23, 2016Assignee: Butamax Advanced Biofuels LLCInventors: Larry Cameron Anthony, Hongxian He, Lixuan Lisa Huang, Daniel P. Okeefe, Arthur Leo Kruckeberg, Yougen Li, Lori Ann Maggio-Hall, Jessica McElvain, Mark J. Nelson, Ranjan Patnaik, Steven Cary Rothman
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Patent number: 9284612Abstract: Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly active ketol-acid reductoisomerase enzyme in addition to other enzymes required for conversion of glucose to isobutanol.Type: GrantFiled: February 22, 2011Date of Patent: March 15, 2016Assignee: Butamax Advanced Biofuels LLCInventors: Der-Ing Liao, Mark J. Nelson, Michael G. Bramucci
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Patent number: 9260708Abstract: Crabtree positive yeast cells that have endogenous expressed pyruvate decarboxylase genes inactivated and an engineered biosynthetic pathway utilizing pyruvate were found to have improved growth and product yield when glucose repression was reduced. These cells were able to grow in media containing a high glucose concentration.Type: GrantFiled: September 29, 2010Date of Patent: February 16, 2016Assignee: Butamax Advanced Biofuels LLCInventors: Larry Cameron Anthony, Mark J. Nelson
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Patent number: 9238801Abstract: Methods for the evolution of NADPH specific ketol-acid reductoisomerase enzymes to acquire NADH specificity are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to utilize NADH are described.Type: GrantFiled: March 15, 2013Date of Patent: January 19, 2016Assignee: Butamax Advanced Biofuels LLCInventors: Yougen Li, Der-Ing Liao, Mark J. Nelson, Daniel P. Okeefe
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Publication number: 20150111269Abstract: Methods for the evolution of NADPH specific ketol-acid reductoisomerase enzymes to acquire NADH specificity are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to utilize NADH are described.Type: ApplicationFiled: December 23, 2014Publication date: April 23, 2015Inventors: Yougen LI, Der-Ing LIAO, Mark J. NELSON, Daniel P. OKEEFE
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Patent number: 8945899Abstract: Methods for the evolution of NADPH specific ketol-acid reductoisomerase enzymes to acquire NADH specificity are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to utilize NADH are described.Type: GrantFiled: December 15, 2009Date of Patent: February 3, 2015Assignee: Butamax Advanced Biofuels LLCInventors: Yougen Li, Der-Ing Liao, Mark J. Nelson, Daniel P. Okeefe
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Patent number: 8911981Abstract: Methods for the evolution of NADPH specific ketol-add reductoisomerase enzymes to acquire NADH specificity are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to utilize NADH are described.Type: GrantFiled: March 15, 2013Date of Patent: December 16, 2014Assignee: Butamax Advanced Biofuels LLCInventors: Yougen Li, Der-Ing Liao, Mark J. Nelson, Daniel P. Okeefe
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Patent number: 8895307Abstract: Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.Type: GrantFiled: July 16, 2012Date of Patent: November 25, 2014Assignee: Butamax Advanced Biofuels LLCInventors: Yougen Li, Der-Ing Liao, Mark J. Nelson, Daniel P. Okeefe
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Publication number: 20140273129Abstract: Provided herein are glycerol-3-phosphate dehydrogenase (GPD) enzymes with increased KM for NADH and GPD enzymes with substantially the same affinity for NADH and NADPH and/or are feedback inhibited by glycerol-3-phosphate. Also provided herein are recombinant microorganisms comprising a heterologous gene encoding GPD and a deletion or disruption in an endogenous gene encoding GPD. Also provided are recombinant microorganisms comprising a heterologous gene encoding GPD and a butanol biosynthetic pathway. Further provided are methods of producing butanol comprising providing the recombinant microorganisms described herein and contacting the recombinant microorganism with at least one fermentable carbon substrate under conditions wherein butanol is produced.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: BUTAMAX ADVANCED BIOFUELS LLCInventors: Ritu Bhalla, Gopal K. Chotani, Michael Dauner, Mark J. Nelson, Daniel P. O'keefe, Caroline M. Peres, Jahnavi Chandra Prasad, Jean-Francois Tomb
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Publication number: 20140057329Abstract: Methods for the evolution of NADPH specific ketol-acid reductoisomerase enzymes to acquire NADH specificity are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to utilize NADH are described.Type: ApplicationFiled: March 15, 2013Publication date: February 27, 2014Applicant: Butamax(TM) Advanced Biofuels LLCInventors: Youngen LI, Der-Ing Liao, Mark J. Nelson, Daniel P. Okeefe
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Publication number: 20130103437Abstract: A method for providing airline patrons with a car service reservation system which facilitates car services and an efficient pricing system for customers on a flat fee, non-metered basis. The ground transportation service provider system allows patrons to rate the transportation service they receive upon arrival to final destination.Type: ApplicationFiled: October 21, 2011Publication date: April 25, 2013Inventor: Mark J. Nelson