Patents by Inventor Mark J. O'Connor

Mark J. O'Connor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods based on the detection of RAD51 foci in tumor cells
    Patent number: 12007393
    Abstract: The invention provides a method allowing to determine whether a subject diagnosed with cancer is sensitive or resistant to an anti-cancer treatment, based on the level of cells with RAD51 foci in a sample containing tumor cells isolated from said subject, wherein the subject has not received at 24 hours prior to the isolation of the sample, a chemotherapy selected from the group consisting of AC, FEC, ECF and navelbine/epirubicin, and wherein the sample has not been treated with a method that induces DNA damage before determining the level of cells with RAD51 foci.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: June 11, 2024
    Assignees: FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ ONCÒLOGICA DE VALL HEBRON, ASTRAZENECA UK LIMITED, XENTECH SAS
    Inventors: Violeta Serra Elizalde, Judith Balmaña Gelpi, Cristina Cruz Zambrano, Alba Llop Guevara, Marta Castroviejo Bermejo, Mark J. O'Connor, Gemma Nicole Jones
  • METHODS BASED ON THE DETECTION OF RAD51 FOCI IN TUMOR CELLS
    Publication number: 20200319182
    Abstract: The invention provides a method allowing to determine whether a subject diagnosed with cancer is sensitive or resistant to an anti-cancer treatment, based on the level of cells with RAD51 foci in a sample containing tumor cells isolated from said subject, wherein the subject has not received at 24 hours prior to the isolation of the sample, a chemotherapy selected from the group consisting of AC, FEC, ECF and navelbine/epirubicin, and wherein the sample has not been treated with a method that induces DNA damage before determining the level of cells with RAD51 foci.
    Type: Application
    Filed: December 21, 2018
    Publication date: October 8, 2020
    Inventors: Violeta SERRA ELIZALDE, Judith BALMAÑA GELPI, Cristina CRUZ ZAMBRANO, Alba LLOP GUEVARA, Marta CASTROVIEJO BERMEJO, Mark J. O?CONNOR, Gemma Nicole JONES
  • Polypeptides from CREB binding protein and related protein p300 for use in transcriptional regulation
    Patent number: 6864054
    Abstract: A method for determining whether a compound inhibits or disrupts an interaction between a first polypeptide comprising a transcriptional adaptor motif (TRAM) and a second polypeptide comprising a TRAM-interaction motif. The first polypeptide and/or second polypeptide may be Mdm-2, p53, TBP, E2F, YY1, CBP/p300 or TF11B, or a viral polypeptide such as a human papillomavirus (HPV) E6 polypeptide from HPV strain (16) or (18).
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: March 8, 2005
    Assignee: Institute of Molecular and Cell Biology
    Inventors: Mark J. O'Connor, Holger Zimmermann