Patents by Inventor Mark J. O'Connor

Mark J. O'Connor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240248088
    Abstract: The invention provides a method allowing to determine whether a subject diagnosed with cancer is sensitive or resistant to an anti-cancer treatment, based on the level of cells with RAD51 foci in a sample containing tumor cells isolated from said subject, wherein the subject has not received at 24 hours prior to the isolation of the sample, a chemotherapy selected from the group consisting of AC, FEC, ECF and navelbine/epirubicin, and wherein the sample has not been treated with a method that induces DNA damage before determining the level of cells with RAD51 foci.
    Type: Application
    Filed: February 16, 2024
    Publication date: July 25, 2024
    Inventors: Violeta SERRA ELIZALDE, Judith BALMAÑA GELPI, Cristina CRUZ ZAMBRANO, Alba LLOP GUEVARA, Marta CASTROVIEJO BERMEJO, Mark J. O’CONNOR, Gemma Nicole JONES
  • Patent number: 12007393
    Abstract: The invention provides a method allowing to determine whether a subject diagnosed with cancer is sensitive or resistant to an anti-cancer treatment, based on the level of cells with RAD51 foci in a sample containing tumor cells isolated from said subject, wherein the subject has not received at 24 hours prior to the isolation of the sample, a chemotherapy selected from the group consisting of AC, FEC, ECF and navelbine/epirubicin, and wherein the sample has not been treated with a method that induces DNA damage before determining the level of cells with RAD51 foci.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: June 11, 2024
    Assignees: FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ ONCÒLOGICA DE VALL HEBRON, ASTRAZENECA UK LIMITED, XENTECH SAS
    Inventors: Violeta Serra Elizalde, Judith Balmaña Gelpi, Cristina Cruz Zambrano, Alba Llop Guevara, Marta Castroviejo Bermejo, Mark J. O'Connor, Gemma Nicole Jones
  • Publication number: 20200319182
    Abstract: The invention provides a method allowing to determine whether a subject diagnosed with cancer is sensitive or resistant to an anti-cancer treatment, based on the level of cells with RAD51 foci in a sample containing tumor cells isolated from said subject, wherein the subject has not received at 24 hours prior to the isolation of the sample, a chemotherapy selected from the group consisting of AC, FEC, ECF and navelbine/epirubicin, and wherein the sample has not been treated with a method that induces DNA damage before determining the level of cells with RAD51 foci.
    Type: Application
    Filed: December 21, 2018
    Publication date: October 8, 2020
    Inventors: Violeta SERRA ELIZALDE, Judith BALMAÑA GELPI, Cristina CRUZ ZAMBRANO, Alba LLOP GUEVARA, Marta CASTROVIEJO BERMEJO, Mark J. O?CONNOR, Gemma Nicole JONES
  • Publication number: 20170317642
    Abstract: This invention includes an optical concentrator which focuses incident sunlight onto a photovoltaic cell or group of photovoltaic cells which is mounted in thermal contact with a radiator comprising ultra-light graphene sheet. In the preferred embodiment, the optical concentrator comprises a thin Fresnel lens, the photovoltaic cell or group of photovoltaic cells comprises a high-efficiency multi junction device, and the graphene radiator comprises a very thin and light sheet. In the preferred embodiment, the graphene radiator is deployed and supported in space as a stressed membrane by employing tension in one or more directions.
    Type: Application
    Filed: April 28, 2016
    Publication date: November 2, 2017
    Inventor: Mark J. O'Neill
  • Patent number: 9027292
    Abstract: A passive collimating skylight system includes an energy-receiving aperture defining a first plane and an energy-delivering aperture defining a second plane that is spaced apart from and non-parallel to the first plane. An energy-directing passageway extends between the energy-receiving aperture and the energy-delivering aperture to redirect radiant energy incident on the energy-collecting aperture over a range of incidence angles to the energy-delivering aperture so that the redirected radiant energy emerges from the energy-delivering aperture over a range of emergence angles that is smaller than the range of incidence angles. The passageway is defined by a wall having a first end that defines the energy-delivering aperture and a second end that defines the energy-collecting aperture, the wall tapering inwardly and having a reflective inner surface along substantially the entire length from the first end to the second end.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: May 12, 2015
    Assignee: Entech Solar, Inc.
    Inventors: Mark J. O'Neill, David Gelbaum, Almus J. McDanal, III, Don H. Spears
  • Publication number: 20140047784
    Abstract: A passive collimating skylight system includes an energy-receiving aperture defining a first plane and an energy-delivering aperture defining a second plane that is spaced apart from and non-parallel to the first plane. An energy-directing passageway extends between the energy-receiving aperture and the energy-delivering aperture to redirect radiant energy incident on the energy-collecting aperture over a range of incidence angles to the energy-delivering aperture so that the redirected radiant energy emerges from the energy-delivering aperture over a range of emergence angles that is smaller than the range of incidence angles. The passageway is defined by a wall having a first end that defines the energy-delivering aperture and a second end that defines the energy-collecting aperture, the wall tapering inwardly and having a reflective inner surface along substantially the entire length from the first end to the second end.
    Type: Application
    Filed: October 22, 2013
    Publication date: February 20, 2014
    Applicant: Entech Solar, Inc.
    Inventors: Mark J. O'Neill, David Gelbaum, Almus J. McDanal, III, Don H. Spears
  • Publication number: 20120272593
    Abstract: A passive collimating skylight system includes an energy-receiving aperture defining a first plane and an energy-delivering aperture defining a second plane that is spaced apart from and non-parallel to the first plane. An energy-directing passageway extends between the energy-receiving aperture and the energy-delivering aperture to redirect radiant energy incident on the energy-collecting aperture over a range of incidence angles to the energy-delivering aperture so that the redirected radiant energy emerges from the energy-delivering aperture over a range of emergence angles that is smaller than the range of incidence angles. The passageway is defined by a wall having a first end that defines the energy-delivering aperture and a second end that defines the energy-collecting aperture, the wall tapering inwardly and having a reflective inner surface along substantially the entire length from the first end to the second end.
    Type: Application
    Filed: April 29, 2011
    Publication date: November 1, 2012
    Inventors: Mark J. O'Neill, David Gelbaum, Almus J. McDanal, III, Don H. Spears
  • Publication number: 20110203638
    Abstract: A photovoltaic receiver for a concentrating photovoltaic module comprises a photovoltaic cell comprising an active area with an electrically conductive gridline; an encapsulating layer disposed substantially about a predetermined portion of the photovoltaic cell where the encapsulating layer comprises a transparent portion disposed over a predetermined portion of the photovoltaic cell active area; and a prismatic cell cover attached to the transparent portion. The prismatic cell cover is dimensioned and configured to refract focused sunlight away from the electrically conductive gridline on the solar cell.
    Type: Application
    Filed: July 2, 2010
    Publication date: August 25, 2011
    Applicant: ENTECH SOLAR, INC.
    Inventor: Mark J. O'Neill
  • Publication number: 20100288332
    Abstract: A solar photovoltaic concentrator panel comprises a Fresnel lens concentrator which may be arched and a photovoltaic receiver within a container comprising a top window. The lens, photovoltaic cell, and window may be affixed in a container with no internal sun-tracking mechanisms or related internal moving parts such as motors, drive systems, or bearings. The window is transparent and the bottom of the container typically dimensioned and configured as a heat exchanger to passively dissipate waste heat from the photovoltaic receiver to the ambient environment. The Fresnel lens concentrator is typically a free-standing Fresnel lens concentrator disposed within the container at a fixed position relative to an interior dimension of the container, optically forming a focal region of concentrated sunlight.
    Type: Application
    Filed: May 7, 2010
    Publication date: November 18, 2010
    Applicant: ENTECH SOLAR, INC.
    Inventor: Mark J. O'Neill
  • Patent number: 7496091
    Abstract: A virtual private branch exchange (PBX) system that routes calls within a packet-switching network. Login information is received from a data device. The login information includes an alias identifying a user at the data device and a network address identifying the location of the data device on the packet-switching network. The virtual private branch exchange system associates the user's private branch exchange extension with the network address and routes calls to the user's (PBX) extension to the data device on the basis of the network address of the data device.
    Type: Grant
    Filed: February 17, 2004
    Date of Patent: February 24, 2009
    Assignee: Verizon Business Global LLC
    Inventors: Thomas J. Galvin, Michael C. Kirchner, Anthony W. S. Moey, Mark J. O'Brien, Joel K. Hanson
  • Patent number: 6864054
    Abstract: A method for determining whether a compound inhibits or disrupts an interaction between a first polypeptide comprising a transcriptional adaptor motif (TRAM) and a second polypeptide comprising a TRAM-interaction motif. The first polypeptide and/or second polypeptide may be Mdm-2, p53, TBP, E2F, YY1, CBP/p300 or TF11B, or a viral polypeptide such as a human papillomavirus (HPV) E6 polypeptide from HPV strain (16) or (18).
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: March 8, 2005
    Assignee: Institute of Molecular and Cell Biology
    Inventors: Mark J. O'Connor, Holger Zimmermann
  • Publication number: 20040160951
    Abstract: A virtual private branch exchange (PBX) system that routes calls within a packet-switching network. Login information is received from a data device. The login information includes an alias identifying a user at the data device and a network address identifying the location of the data device on the packet-switching network. The virtual private branch exchange system associates the user's private branch exchange extension with the network address and routes calls to the user's (PBX) extension to the data device on the basis of the network address of the data device.
    Type: Application
    Filed: February 17, 2004
    Publication date: August 19, 2004
    Applicant: WORLDCOM, Inc.
    Inventors: Thomas J. Galvin, Michael C. Kirchner, Anthony W.S. Moey, Mark J. O'Brien, Joel K. Hanson
  • Patent number: 6775272
    Abstract: A virtual private branch exchange (PBX) system that routes calls within a packet-switching network. Login information is received from a data device. The login information includes an alias identifying a user at the data device and a network address identifying the location of the data device on the packet-switching network. The virtual private branch exchange system associates the user's private branch exchange extension with the network address and routes calls to the user's (PBX) extension to the data device on the basis of the network address of the data device.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: August 10, 2004
    Assignee: MCI, Inc.
    Inventors: Thomas J. Galvin, Michael C. Kirchner, Anthony W. S. Moey, Mark J. O'Brien, Joel K. Hanson
  • Patent number: 6724754
    Abstract: A virtual private branch exchange (PBX) system that routes calls within a packet-switching network. Login information is received from a data device. The login information includes an alias identifying a user at the data device and a network address identifying the location of the data device on the packet-switching network. The virtual private branch exchange system associates the user's private branch exchange extension with the network address and routes calls to the user's (PBX) extension to the data device on the basis of the network address of the data device.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: April 20, 2004
    Assignee: WorldCom, Inc.
    Inventors: Thomas J. Galvin, Michael C. Kirchner, Anthony W.S. Moey, Mark J. O'Brien, Joel K. Hanson
  • Publication number: 20020114329
    Abstract: A virtual private branch exchange (PBX) system that routes calls within a packet-switching network. Login information is received from a data device. The login information includes an alias identifying a user at the data device and a network address identifying the location of the data device on the packet-switching network. The virtual private branch exchange system associates the user's private branch exchange extension with the network address and routes calls to the user's (PBX) extension to the data device on the basis of the network address of the data device.
    Type: Application
    Filed: March 25, 2002
    Publication date: August 22, 2002
    Applicant: WorldCom, INC.
    Inventors: Thomas J. Galvin, Michael C. Kirchner, Anthony W.S. Moey, Mark J. O'Brien, Joel K. Hanson
  • Patent number: 6436796
    Abstract: A thermal processing system and method for processing a semiconductor substrate. An inductor couples energy to a susceptor, wherein the spacing between the inductor and the susceptor is configured for the steady-state portions of a CVD epitaxial deposition process. The temperature uniformity of the susceptor is improved during the transient portions of the process, the heat ramp-up and cool down, by varying the distance of separation between the inductor and the susceptor. Temperature non-uniformities are a common cause of slip. Additional aspects of the invention provide for improved thermal shielding of the edges and top surface of the susceptor. Thicker susceptors also improve temperature uniformity.
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: August 20, 2002
    Assignee: Mattson Technology, Inc.
    Inventors: Robert D. Mailho, Mark J. O'Hara, Glenn A. Pfefferkorn, Gary Lee Evans, Kristian E. Johnsgard
  • Patent number: 6393017
    Abstract: A virtual private branch exchange (PBX) system that routes calls within a packet-switching network. Login information is received from a data device. The login information includes an alias identifying a user at the data device and a network address identifying the location of the data device on the packet-switching network. The virtual private branch exchange system associates the user's private branch exchange extension with the network address and routes calls to the user's (PBX) extension to the data device on the basis of the network address of the data device.
    Type: Grant
    Filed: November 17, 1999
    Date of Patent: May 21, 2002
    Assignee: WorldCom, Inc.
    Inventors: Thomas J. Galvin, Michael C. Kirchner, Anthony W. S. Moey, Mark J. O'Brien, Joel K. Hanson
  • Patent number: 6351464
    Abstract: A system and method for routing a telephone call on a PSTN network to a data device. The present invention utilizes an automatic call processing system that has a one number location service. A called party provides a calling profile that is stored in the automatic call processing (ACP) system. When a call is placed to a telephone number that is assigned to the called party, the call is routed to the ACP system. The ACP system calls each of the numbers of the calling profile for that called party until that party is reached. At least one of the destinations in the calling profile is a logical address for a data network. The automatic call processing system recognizes the logical address and queries a directory to determine if an IP address has been registered in the directory for the logical address of the called party.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: February 26, 2002
    Assignee: MCI WorldCom, Inc.
    Inventors: Tom J. Galvin, Joel K. Hanson, Mike C. Kirchner, Tony W. S. Moey, Mark J. O'Brien
  • Patent number: 6190450
    Abstract: An improved asbestos-free composition for the manufacture of commercial baking stones and an improved baking stone made from the improved asbestos-free composition are disclosed. The baking stone is asbestos-free, non-hazardous and is ideal for commercial ovens designed for baking pizza and bread. The improved composition for the manufacture of baking stones includes 15-45% portland cement, 30-55% fireclay, 4-11% mullite, 2-6% silica, 0.5-3% glass fiber, 10-30% water and 0.03-1.5% of a plasticizer. After curing, the preferred water content of the cured baking stone will range from 6-10% and the composition of the cured baking stone will be 15-50% portland cement, 30-55% fireclay, 4-12% mullite, 2-7% silica, 0.5-3% glass fiber, 6-10% water and 0.03-1.5% of a plasticizer. Also disclosed is an improved composition for the manufacture of baking stones that includes a pigment in order to produce a colored baking stone.
    Type: Grant
    Filed: September 9, 1998
    Date of Patent: February 20, 2001
    Inventor: Mark J. O'Toole
  • Patent number: 6031179
    Abstract: A color-mixing lens for use in a concentrator system and methods of manufacture and operation thereof. The color-mixing lens includes: (1) a light-transmissive substrate that receives broad spectrum light from a source, (2) a first plurality of prisms, located on the substrate, that refract and chromatically disperse the light received therein toward a first plurality of locations on an active region of a target cell, and (3) a second plurality of prisms located on the substrate that refract and chromatically disperse the light received therein toward a second plurality of locations on the active region. Relative dimensions of the first and second pluralities of prisms are preselected to cause the chromatically-dispersed light to mix and thereby increase a power output of the target cell by reducing inter-junction currents therein.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: February 29, 2000
    Assignee: Entech, Inc.
    Inventor: Mark J. O'Neill