Patents by Inventor Mark J. Osborn

Mark J. Osborn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Drug-Resistant Immune Cells and Methods of Use Thereof
    Publication number: 20210213062
    Abstract: The present disclosure provides modified cells including pluripotent stem cells, hematopoietic precursor cells, and hematopoietic cells (e.g., modified Tregs) that are steroid and/or calcineurin inhibitor-resistant. The present disclosure provides methods for generating steroid and/or calcineurin inhibitor-resistant modified cells including pluripotent stem cells, hematopoietic precursor cells, and hematopoietic cells. Also provided herein are compositions and methods of treatment.
    Type: Application
    Filed: May 16, 2019
    Publication date: July 15, 2021
    Inventors: Mark J. Osborn, Keli Hippen, Bruce R. Blazer
  • Method for correcting a genetic sequence
    Patent number: 10648002
    Abstract: Methods of gene correction, methods of generating induced pluripotent stem cells (iPSCs), and methods of deriving multi-lineage cell types with therapeutic value. In some embodiments, the gene correction affects the expression and/or function of the functional type VII collagen protein (C7).
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: May 12, 2020
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Beau R. Webber, Mark J. Osborn, Jakub Tolar, Bruce R. Blazar
  • METHOD FOR CORRECTING A GENETIC SEQUENCE
    Publication number: 20180142262
    Abstract: Methods of gene correction, methods of generating induced pluripotent stem cells (iPSCs), and methods of deriving multi-lineage cell types with therapeutic value. In some embodiments, the gene correction affects the expression and/or function of the functional type VII collagen protein (C7).
    Type: Application
    Filed: November 22, 2017
    Publication date: May 24, 2018
    Inventors: Beau R. Webber, Mark J. Osborn, Jakub Tolar, Bruce R. Blazar
  • TALEN-based gene correction
    Patent number: 9393257
    Abstract: The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: July 19, 2016
    Assignee: Regents of the University of Minnesota
    Inventors: Mark J. Osborn, Jakub Tolar, Bruce Blazar, Daniel F. Voytas
  • TALEN-BASED GENE CORRECTION
    Publication number: 20140256798
    Abstract: The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 11, 2014
    Inventors: Mark J. Osborn, Jakub Tolar, Bruce Blazar, Daniel F. Voytas