Patents by Inventor Mark J. Rieder

Mark J. Rieder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods using randomer-containing synthetic molecules
    Patent number: 11248253
    Abstract: Methods are provided for correction of amplification bias and quantitation of adaptive immune cells in a sample using synthetic templates that include random oligonucleotide sequences.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: February 15, 2022
    Assignee: Adaptive Biotechnologies Corporation
    Inventors: Anna M. Sherwood, Ryan O. Emerson, Harlan S. Robins, Mark J. Rieder, Joe Parsons
  • METHODS FOR DIAGNOSING INFECTIOUS DISEASE AND DETERMINING HLA STATUS USING IMMUNE REPERTOIRE SEQUENCING
    Publication number: 20210381050
    Abstract: Methods are provided for predicting a subject's infection status using high-throughput T cell receptor sequencing to match the subject's TCR repertoire to a known set of disease-associated T cell receptor sequences. The methods of the present invention may be used to predict the status of several infectious agents in a single sample from a subject. Methods are also provided for predicting a subject's HLA status using high-throughput immune receptor sequencing.
    Type: Application
    Filed: June 9, 2021
    Publication date: December 9, 2021
    Inventors: Ryan O. Emerson, Harlan S. Robins, Mark J. Rieder, William S. Dewitt, III, Christopher S. Carlson
  • Methods Using Randomer-Containing Synthetic Molecules
    Publication number: 20200325526
    Abstract: Methods are provided for correction of amplification bias and quantitation of adaptive immune cells in a sample using synthetic templates that include random oligonucleotide sequences.
    Type: Application
    Filed: May 1, 2020
    Publication date: October 15, 2020
    Inventors: Anna M. SHERWOOD, Ryan O. EMERSON, Harlan S. ROBINS, Mark J. RIEDER, Joe PARSONS
  • Quantification of adaptive immune cell genomes in a complex mixture of cells
    Patent number: 10150996
    Abstract: A relative representation of adaptive immune cells in a biological sample is quantified using multiplex PCR and sequencing of adaptive immune cells, control genes, and synthetic template molecules. Disclosed herein are methods for quantifying a number of adaptive immune cells in a biological sample, and methods for quantifying a relative representation of adaptive immune cells in a biological sample that comprises a mixture of cells comprising adaptive immune cells and cells that are not adaptive immune cells. Methods are provided for amplifying by multiplex PCR and sequencing a first set of synthetic templates each comprising one TCR or IgV segment and one TCR of Ig J or C segment and a unique bar code.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: December 11, 2018
    Assignee: ADAPTIVE BIOTECHNOLOGIES CORP.
    Inventors: Harlan Saul Robins, Christopher Scott Carlson, Mark J. Rieder, Anna M. Sherwood, Ryan O. Emerson
  • METHODS USING RANDOMER-CONTAINING SYNTHETIC MOLECULES
    Publication number: 20170292149
    Abstract: Methods are provided for correction of amplification bias and quantitation of adaptive immune cells in a sample using synthetic templates that include random oligonucleotide sequences.
    Type: Application
    Filed: March 5, 2015
    Publication date: October 12, 2017
    Inventors: Anna M. SHERWOOD, Ryan O. EMERSON, Harlan S. ROBINS, Mark J. RIEDER, Joe PARSONS
  • QUANTIFICATION OF ADAPTIVE IMMUNE CELL GENOMES IN A COMPLEX MIXTURE OF CELLS
    Publication number: 20170037469
    Abstract: A relative representation of adaptive immune cells in a biological sample is quantified using multiplex PCR and sequencing of adaptive immune cells, control genes, and synthetic template molecules. Disclosed herein are methods for quantifying a number of adaptive immune cells in a biological sample, and methods for quantifying a relative representation of adaptive immune cells in a biological sample that comprises a mixture of cells comprising adaptive immune cells and cells that are not adaptive immune cells. Methods are provided for amplifying by multiplex PCR and sequencing a first set of synthetic templates each comprising one TCR or IgV segment and one TCR of Ig J or C segment and a unique bar code.
    Type: Application
    Filed: March 5, 2015
    Publication date: February 9, 2017
    Inventors: Harlan Saul ROBINS, Christopher Scott CARLSON, Mark J. RIEDER, Anna M. SHERWOOD, Ryan O. EMERSON
  • Methods and compositions for predicting drug responses
    Patent number: 9074257
    Abstract: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: July 7, 2015
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Mark J. Rieder, Allan Rettie
  • METHODS AND COMPOSITIONS FOR PREDICTING DRUG RESPONSES
    Publication number: 20140148505
    Abstract: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.
    Type: Application
    Filed: November 7, 2013
    Publication date: May 29, 2014
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Mark J. Rieder, Allan Rettie
  • Methods and compositions for predicting drug responses
    Patent number: 8614060
    Abstract: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: December 24, 2013
    Assignee: University of Washington
    Inventors: Mark J. Rieder, Allan Rettie
  • Methods and compositions for predicting drug responses
    Patent number: 8153366
    Abstract: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: April 10, 2012
    Assignee: University of Washington
    Inventors: Mark J. Rieder, Allan Rettie
  • METHODS AND COMPOSITIONS FOR PREDICTING DRUG RESPONSES
    Publication number: 20110251272
    Abstract: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.
    Type: Application
    Filed: January 18, 2011
    Publication date: October 13, 2011
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Mark J. Rieder, Allan Rettie
  • Methods and compositions for predicting drug responses
    Patent number: 7888016
    Abstract: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: February 15, 2011
    Assignee: The University of Washington
    Inventors: Mark J. Rieder, Allan Rettie
  • Methods and compositions for predicting drug responses
    Patent number: 7829282
    Abstract: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: November 9, 2010
    Assignee: The University of Washington
    Inventors: Mark J. Rieder, Allan Rettie
  • METHODS AND COMPOSITIONS FOR PREDICTING DRUG RESPONSES
    Publication number: 20080318219
    Abstract: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.
    Type: Application
    Filed: March 16, 2007
    Publication date: December 25, 2008
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Mark J. RIEDER, Allan RETTIE
  • Methods and compositions for detecting VKORC1 single nucleotide polymorphisms
    Patent number: 7445896
    Abstract: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: November 4, 2008
    Assignee: University of Washington
    Inventors: Mark J. Rieder, Allan Rettie