Patents by Inventor Mark J. Sartain

Mark J. Sartain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biomarkers of tuberculosis that distinguish disease categories: use as serodiagnostic antigens
    Patent number: 7776341
    Abstract: Mycobacterial proteins from culture filtrate or cytosol are disclosed as being useful B cell antigens for early diagnosis of mycobacterial disease, particularly in humans. These proteins include four that had not previously been recognized as B cell antigens (LppZ protein encoded by Mtb gene Rv3006; SodC protein encoded by Mtb gene Rv0432; BfrB protein encoded by Mtb gene Rv3841 and TrxC protein encoded by Mtb gene Rv3914). Antigenic compositions include these proteins and/or peptide fragments thereof, in various combinations with each other or with one or more of a set of 10 additional Mtb proteins known to be antigens (in particular early antigens. Methods and kits for using these antigenic composition for early diagnosis of mycobacterial infection and disease are also disclosed.
    Type: Grant
    Filed: August 10, 2007
    Date of Patent: August 17, 2010
    Assignees: Colorado State University Research Foundation, New York University
    Inventors: John T. Belisle, Mark J. Sartain, Suman Laal
  • BIOMARKERS OF TUBERCULOSIS THAT DISTINGUISH DISEASE CATEGORIES: USE AS SERODIAGNOSTIC ANTIGENS
    Publication number: 20080171345
    Abstract: Mycobacterial proteins from culture filtrate or cytosol are disclosed as being useful B cell antigens for early diagnosis of mycobacterial disease, particularly in humans. These proteins include four that had not previously been recognized as B cell antigens (LppZ protein encoded by Mtb gene Rv3006; SodC protein encoded by Mtb gene Rv0432; BfrB protein encoded by Mtb gene Rv3841 and TrxC protein encoded byMtb gene Rv3914). Antigenic compositions include these proteins and/or peptide fragments thereof, in various combinations with each other or with one or more of a set of 10 additional Mtb proteins known to be antigens (in paricular early antigens. Methods and kits for using these antigenic composition for early diagnosis of mycobacterial infection and disease are also disclosed.
    Type: Application
    Filed: August 10, 2007
    Publication date: July 17, 2008
    Applicants: Colorado State University Research Foundation, New York University
    Inventors: John T. BELISLE, Mark J. Sartain, Suman Laal