Patents by Inventor Mark J Schnitzer
Mark J Schnitzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230323342Abstract: Provided herein are materials and methods useful for facilitating transgene recombination. The present disclosure relates to, for example, techniques for manipulating recombination frequencies and generating organisms that contain multiple transgenic elements docking at the same locus on a single chromosome. The time consumed by the entire recombination process is proportional to the logarithm of the number of transgenes to be recombined.Type: ApplicationFiled: October 15, 2021Publication date: October 12, 2023Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Junjie LUO, Mark J. SCHNITZER, Cheng HUANG
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Publication number: 20230200656Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.Type: ApplicationFiled: August 26, 2022Publication date: June 29, 2023Inventors: Kunal Ghosh, Laurie D. Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
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Patent number: 11259703Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.Type: GrantFiled: October 26, 2020Date of Patent: March 1, 2022Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kunal Ghosh, Laurie D. Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
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Publication number: 20210267458Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.Type: ApplicationFiled: October 26, 2020Publication date: September 2, 2021Inventors: Kunal Ghosh, Laurie D. Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
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Patent number: 10813552Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.Type: GrantFiled: February 27, 2017Date of Patent: October 27, 2020Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kunal Ghosh, Laurie D. Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
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Publication number: 20200100659Abstract: Biological tissue such as skeletal and cardiac muscle can be imaged by using an objective-based probe in the tissue and scanning at a sufficiently fast rate to mitigate motion artifacts due to physiological motion. According to one example embodiment, such a probe is part of a system that is capable of reverse-direction high-resolution imaging without needing to stain or otherwise introduce a foreign element used to generate or otherwise increase the sensed light. The probe can include a light generator for generating light pulses that are directed towards structures located within the thick tissue. The system can additionally include aspects that lessen adverse image-quality degradation. Further, the system can additionally be constructed as a hand-held device.Type: ApplicationFiled: September 27, 2019Publication date: April 2, 2020Inventors: Gabriel Nestor Sanchez, Scott L. Delp, Mark J. Schnitzer, Michael E. Llewellyn
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Patent number: 10499797Abstract: Biological tissue such as skeletal and cardiac muscle can be imaged by using an objective-based probe in the tissue and scanning at a sufficiently fast rate to mitigate motion artifacts due to physiological motion. According to one example embodiment, such a probe is part of a system that is capable of reverse-direction high-resolution imaging without needing to stain or otherwise introduce a foreign element used to generate or otherwise increase the sensed light. The probe can include a light generator for generating light pulses that are directed towards structures located within the thick tissue. The system can additionally include aspects that lessen adverse image-quality degradation. Further, the system can additionally be constructed as a hand-held device.Type: GrantFiled: November 18, 2014Date of Patent: December 10, 2019Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Gabriel Nestor Sanchez, Scott L. Delp, Mark J. Schnitzer, Michael E. Llewellyn
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Patent number: 10292592Abstract: A system and method for monitoring biological parameters in freely moving animals that, in the illustrative embodiment, comprises a two-color optical measurement/recording system that is combined with a fluorescent protein reporter of cellular membrane potentials and a fluorescent protein that is insensitive to such cellular membrane potentials. The two wavelengths are used to un-mix physiological artifacts in recordings that occur in freely moving animals.Type: GrantFiled: November 12, 2015Date of Patent: May 21, 2019Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Jesse D. Marshall, Mark J. Schnitzer
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Publication number: 20190133449Abstract: Analysis of live beings is facilitated. According to an example embodiment of the present invention, a light-directing arrangement such as an endoscope is mounted to a live being. Optics in the light-directing arrangement are implemented to pass source light (e.g., laser excitation light) into the live being, and to pass light from the live being for detection thereof. The light from the live being may include, for example, photons emitted in response to the laser excitation light (i.e., fluoresced). The detected light is then used to detect a characteristic of the live being.Type: ApplicationFiled: September 24, 2018Publication date: May 9, 2019Inventors: Benjamin A. Flusberg, Eric David Cocker, Juergen Claus Jung, Mark J. Schnitzer
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Publication number: 20170296060Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.Type: ApplicationFiled: February 27, 2017Publication date: October 19, 2017Inventors: Kunal Ghosh, Laurie D. Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
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Patent number: 9629554Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.Type: GrantFiled: September 17, 2015Date of Patent: April 25, 2017Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kunal Ghosh, Laurie Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
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Patent number: 9498135Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.Type: GrantFiled: October 15, 2015Date of Patent: November 22, 2016Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kunal Ghosh, Laurie Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
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Patent number: 9474448Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.Type: GrantFiled: October 15, 2015Date of Patent: October 25, 2016Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kunal Ghosh, Laurie Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
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Publication number: 20160135754Abstract: A system and method for monitoring biological parameters in freely moving animals that, in the illustrative embodiment, comprises a two-color optical measurement/recording system that is combined with a fluorescent protein reporter of cellular membrane potentials and a fluorescent protein that is insensitive to such cellular membrane potentials. The two wavelengths are used to un-mix physiological artifacts in recordings that occur in freely moving animals.Type: ApplicationFiled: November 12, 2015Publication date: May 19, 2016Inventors: Jesse D. Marshall, Mark J. Schnitzer
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Publication number: 20160033752Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.Type: ApplicationFiled: October 15, 2015Publication date: February 4, 2016Inventors: Kunal Ghosh, Laurie Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
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Publication number: 20160029893Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.Type: ApplicationFiled: October 15, 2015Publication date: February 4, 2016Inventors: Kunal Ghosh, Laurie Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
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Publication number: 20160004063Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.Type: ApplicationFiled: September 17, 2015Publication date: January 7, 2016Inventors: Kunal Ghosh, Laurie Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
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Patent number: 9195043Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.Type: GrantFiled: August 25, 2011Date of Patent: November 24, 2015Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kunal Ghosh, Laurie Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
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Publication number: 20150141846Abstract: Biological tissue such as skeletal and cardiac muscle can be imaged by using an objective-based probe in the tissue and scanning at a sufficiently fast rate to mitigate motion artifacts due to physiological motion. According to one example embodiment, such a probe is part of a system that is capable of reverse-direction high-resolution imaging without needing to stain or otherwise introduce a foreign element used to generate or otherwise increase the sensed light. The probe can include a light generator for generating light pulses that are directed towards structures located within the thick tissue. The system can additionally include aspects that lessen adverse image-quality degradation. Further, the system can additionally be constructed as a hand-held device.Type: ApplicationFiled: November 18, 2014Publication date: May 21, 2015Inventors: Gabriel Nestor Sanchez, Scott L. Delp, Mark J. Schnitzer, Michael E. Llewellyn
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Patent number: 8897858Abstract: Biological tissue such as skeletal and cardiac muscle can be imaged by using an objective-based probe in the tissue and scanning at a sufficiently fast rate to mitigate motion artifacts due to physiological motion. According to one example embodiment, such a probe is part of a system that is capable of reverse-direction high-resolution imaging without needing to stain or otherwise introduce a foreign element used to generate or otherwise increase the sensed light. The probe can include a light generator for generating light pulses that are directed towards structures located within the thick tissue. The system can additionally include aspects that lessen adverse image-quality degradation. Further, the system can additionally be constructed as a hand-held device.Type: GrantFiled: November 28, 2011Date of Patent: November 25, 2014Assignee: The Board of Trustees of the Leland Stanford Junior UniverityInventors: Gabriel Nestor Sanchez, Scott L. Delp, Mark J. Schnitzer, Michael E. Llewellyn