Patents by Inventor Mark J. Soloski

Mark J. Soloski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ASSAYS FOR DETECTION OF ACUTE LYME DISEASE
    Publication number: 20230399698
    Abstract: The present disclosure relates to measuring gene expression of cells of a blood sample obtained from a mammalian subject suspected of having a tick-borne disease. In particular, the present disclosure provides tools for determining whether a human subject has acute Lyme disease by transcriptome profiling a peripheral blood mononuclear cell sample from the subject.
    Type: Application
    Filed: June 9, 2023
    Publication date: December 14, 2023
    Applicants: The Regents of the University of California, The Johns Hopkins University
    Inventors: Charles Y. CHIU, Jerome BOUQUET, Mark J. SOLOSKI, John N. AUCOTT
  • ASSAYS FOR DETECTION OF ACUTE LYME DISEASE
    Publication number: 20200291477
    Abstract: The present disclosure relates to measuring gene expression of cells of a blood sample obtained from a mammalian subject suspected of having a tick-borne disease. In particular, the present disclosure provides tools for determining whether a human subject has acute Lyme disease by transcriptome profiling a peripheral blood mononuclear cell sample from the subject.
    Type: Application
    Filed: November 27, 2018
    Publication date: September 17, 2020
    Inventors: Charles Y. CHIU, Jerome BOUQUET, Mark J. SOLOSKI, John N. AUCOTT
  • Elevated CCL19 after completion of therapy for acute lyme disease identifies patients at risk for development of post-treatment lyme disease syndrome who will benefit from further antibiotic therapy
    Patent number: 10481165
    Abstract: The present invention relates to the field of Lyme disease. More specifically, the present invention provides methods and composition useful for the treatment of Lyme disease. In one aspect, the present invention provides compositions and methods for treating a patient at risk for or likely to develop post-treatment Lyme disease syndrome (PTLDS). In certain embodiments, the patient is already undergoing a first course of antibiotic treatment for Lyme disease. In a specific embodiment, a method comprises the step of prescribing or administering a second course of antibiotic treatment to a patient who is determined to have an increased level of CCL19 as compared to a control after completing a first course of antibiotics for Lyme disease.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: November 19, 2019
    Assignee: The Johns Hopkins University
    Inventors: John N. Aucott, Mark J. Soloski
  • ELEVATED CCL19 AFTER COMPLETION OF THERAPY FOR ACUTE LYME DISEASE IDENTIFIES PATIENTS AT RISK FOR DEVELOPMENT OF POST-TREATMENT LYME DISEASE SYNDROME WHO WILL BENEFIT FROM FURTHER ANTIBIOTIC THERAPY
    Publication number: 20190178893
    Abstract: The present invention relates to the field of Lyme disease. More specifically, the present invention provides methods and composition useful for the treatment of Lyme disease. In one aspect, the present invention provides compositions and methods for treating a patient at risk for or likely to develop post-treatment Lyme disease syndrome (PTLDS). In certain embodiments, the patient is already undergoing a first course of antibiotic treatment for Lyme disease. In a specific embodiment, a method comprises the step of prescribing or administering a second course of antibiotic treatment to a patient who is determined to have an increased level of CCL19 as compared to a control after completing a first course of antibiotics for Lyme disease.
    Type: Application
    Filed: August 8, 2018
    Publication date: June 13, 2019
    Inventors: John N. Aucott, Mark J. Soloski
  • ELEVATED CCL19 AFTER COMPLETION OF THERAPY FOR ACUTE LYME DISEASE IDENTIFIES PATIENTS AT RISK FOR DEVELOPMENT OF POST-TREATMENT LYME DISEASE SYNDROME WHO WILL BENEFIT FROM FURTHER ANTIBIOTIC THERAPY
    Publication number: 20160305956
    Abstract: The present invention relates to the field of Lyme disease. More specifically, the present invention provides methods and composition useful for the treatment of Lyme disease. In one aspect, the present invention provides compositions and methods for treating a patient at risk for or likely to develop post-treatment Lyme disease syndrome (PTLDS). In certain embodiments, the patient is already undergoing a first course of antibiotic treatment for Lyme disease. In a specific embodiment, a method comprises the step of prescribing or administering a second course of antibiotic treatment to a patient who is determined to have an increased level of CCL19 as compared to a control after completing a first course of antibiotics for Lyme disease.
    Type: Application
    Filed: April 18, 2016
    Publication date: October 20, 2016
    Inventors: John N. Aucott, Mark J. Soloski