Patents by Inventor Mark J. Zylka

Mark J. Zylka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATING ANGELMAN SYNDROME
    Publication number: 20210054370
    Abstract: This invention relates to methods and compositions for treating Angelman syndrome, including administering to a subject an effective amount of a clustered regularly interspersed short palindromic repeat (CRISPR)-associated endonuclease and one or more than one guide RNA molecules having complementarity to a target nucleotide sequence in UBE3A-ATS in cells of the subject.
    Type: Application
    Filed: February 27, 2019
    Publication date: February 25, 2021
    Inventors: Mark J. Zylka, Justin Matthew Wolter, Giulia Fragola, Jeremy Mark Simon, Hangqian Mao
  • Assay employing G protein-coupled receptor expressed in dorsal root ganglia
    Patent number: 7510845
    Abstract: The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: March 31, 2009
    Assignee: California Institute of Technology
    Inventors: David J. Anderson, Xinzhong Dong, Mark J. Zylka, Sang-Kyou Han, Melvin I. Simon