Abstract: Methods and systems for performing dose regimen modification are provided. The methods and systems perform operations comprising: receiving prescription related data for treating a patient with an expected level of efficacy, the prescription related data comprising medication regimen information including dose and interval; determining, using a model, a first amount of drug waste based on the prescription related data; comparing the first amount of drug waste to a threshold value; and in response to determining that the first amount of drug waste transgresses the threshold value, identifying an alternate medication regimen that is associated with a treatment having a given level of efficacy corresponding to the expected level of efficacy, the alternate medication regimen being associated with a second amount of drug waste that is lower than the first amount of drug waste; and triggering a notification associated with the alternate medication regimen.

Abstract: The invention relates to a method for producing isocyanates by reacting at least one amine or the salt thereof with a stoichiometric excess of phosgene in the condensed phase in the presence of a solvent, having the steps of: A) transitioning to a hot phosgenation process and B) expelling remaining phosgene and/or hydrogen chloride. The invention is characterized in that the reaction is carried out in batches in at least two reactors which are arranged parallel to one another and in that step A) and/or step B) is carried out asynchronously in at least two of the reactors arranged parallel to one another.

Abstract: The invention relates to a method for preparing isocyanates by reacting corresponding amines with phosgene. The invention further relates to an apparatus for separating exhaust gas flows from a phosgenation reaction.

Abstract: Methods and systems for performing dose regimen modification are provided. The methods and systems perform operations comprising: receiving prescription related data for treating a patient with an expected level of efficacy, the prescription related data comprising medication regimen information including dose and interval; determining, using a model, a first amount of drug waste based on the prescription related data; comparing the first amount of drug waste to a threshold value; and in response to determining that the first amount of drug waste transgresses the threshold value, identifying an alternate medication regimen that is associated with a treatment having a given level of efficacy corresponding to the expected level of efficacy, the alternate medication regimen being associated with a second amount of drug waste that is lower than the first amount of drug waste; and triggering a notification associated with the alternate medication regimen.

Abstract: Methods and systems for performing dose regimen modification are provided. The methods and systems perform operations comprising: receiving prescription related data for treating a patient with an expected level of efficacy, the prescription related data comprising medication regimen information including dose and interval; determining, using a model, a first amount of drug waste based on the prescription related data; comparing the first amount of drug waste to a threshold value; and in response to determining that the first amount of drug waste transgresses the threshold value, identifying an alternate medication regimen that is associated with a treatment having a given level of efficacy corresponding to the expected level of efficacy, the alternate medication regimen being associated with a second amount of drug waste that is lower than the first amount of drug waste; and triggering a notification associated with the alternate medication regimen.

Abstract: Methods and systems for performing dose regimen modification are provided. The methods and systems perform operations comprising: receiving prescription related data for treating a patient with an expected level of efficacy, the prescription related data comprising medication regimen information including dose and interval; determining, using a model, a first amount of drug waste based on the prescription related data; comparing the first amount of drug waste to a threshold value; and in response to determining that the first amount of drug waste transgresses the threshold value, identifying an alternate medication regimen that is associated with a treatment having a given level of efficacy corresponding to the expected level of efficacy, the alternate medication regimen being associated with a second amount of drug waste that is lower than the first amount of drug waste; and triggering a notification associated with the alternate medication regimen.

Abstract: Methods and apparatus for peer to peer network communication. In one implementation, a method of communicating between a first client system and a second client system includes: discovering first address information for a first client system connected to a first network address translation device; sharing the first address information with a second client system; receiving second address information for the second client system; and establishing communication between the first client system and the second client system using the second address information.

Abstract: The present invention provides a self-contained power management device, such as a power management IC or an IC including power management functions, which allow sequenced start up of power supplies without the need for an external sequencer and with a simple user configurable arrangement.

Abstract: The present invention provides a self-contained power management device, such as a power management IC or an IC including power management functions, which allow sequenced start up of power supplies without the need for an external sequencer and with a simple user configurable arrangement.

Abstract: A method for use in processing audio includes receiving audio data associated with each of two or more characters in a virtual world, determining a proximity of the other characters in the virtual world for each of the characters, altering the received audio data based on the determined proximity of another one of the characters for each of the characters, and providing the altered audio data to a client associated with the other character for which the audio data was altered for each of the characters.

Abstract: Methods and apparatus for peer to peer network communication. In one implementation, a method of communicating between a first client system and a second client system includes: discovering first address information for a first client system connected to a first network address translation device; sharing the first address information with a second client system; receiving second address information for the second client system; and establishing communication between the first client system and the second client system using the second address information.

Abstract: Methods and apparatus for peer to peer network communication. In one implementation, a method of communicating between a first client system and a second client system includes: discovering first address information for a first client system connected to a first network address translation device; sharing the first address information with a second client system; receiving second address information for the second client system; and establishing communication between the first client system and the second client system using the second address information.