Patents by Inventor Mark James Nelson

Mark James Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pseudomonas putida amidase polypeptide useful for the production of chiral amides and acids
    Patent number: 6251650
    Abstract: The present invention provides a nitrile hydratase nucleic acid fragment isolated from Pseudomonas putida which encodes a nitrile hydratase activity capable of catalyzing the hydrolysis of certain racemic nitriles to the corresponding R- or S-amides. Also provided are transformed microorganisms capable of the active expression of said nitrile hydratase activity. Additionally, the invention provides a transformant harboring the nitrile hydratase gene in conjunction with an amidase gene, both of which may be co-expressed producing active nitrile hydratase and amidase enzymes respectively. Methods for the production of such enantiomeric materials are also provided.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: June 26, 2001
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert Donald Fallon, Mark James Nelson, Mark Scott Payne
  • Polypeptides and polypeptide subunits of a stereospecific nitrile hydratase enzyme
    Patent number: 6133421
    Abstract: 350 The present invention provides a nitrile hydratase nucleic acid fragment isolated from Pseudomonas putida which encodes a nitrile hydratase activity capable of catalyzing the hydrolysis of certain racemic nitriles to the corresponding R- or S-amides. Also provided are transformed microorganisms capable of the active expression of said nitrile hydratase activity. Additionally, the invention provides a transformant harboring the nitrile hydratase gene in conjunction with an amidase gene, both of which may be co-expressed producing active nitrile hydratase and amidase enzymes respectively. Methods for the production of such enantiomeric materials are also provided.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: October 17, 2000
    Assignee: E. I. du Pont de Nemours & Company
    Inventors: Robert Donald Fallon, Mark James Nelson, Mark Scott Payne
  • Method for using hydratase or a hydratase-amidase fusion for stereospecifically bioconverting certain racemic nitriles to the corresponding enatiomeric R--or S-amide or s-carboxylic acid
    Patent number: 5888785
    Abstract: The present invention provides a nitrile hydratase nucleic acid fragment isolated from Pseudomonas putida which encodes a nitrile hydratase activity capable of catalyzing the hydrolysis of certain racemic nitrites to the corresponding R- or S-amides. Also provided are transformed microorganisms capable of the active expression of said nitrile hydratase activity. Additionally, the invention provides a transformant harboring the nitrile hydratase gene in conjunction with an amidase gene, both of which may be co-expressed producing active nitrile hydratase and amidase enzymes respectively. Methods for the production of such enantiomeric materials are also provided.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: March 30, 1999
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert Donald Fallon, Mark James Nelson, Mark Scott Payne
  • Nucleic acid fragments encoding stereospecific nitrile hydratase and amidase enzymes and recombinant organisms expressing those enzymes useful for the production of chiral amides and acids
    Patent number: 5811286
    Abstract: The present invention provides a nitrile hydratase nucleic acid fragment isolated from Pseudomonas putida which encodes a nitrile hydratase activity capable of catalyzing the hydrolysis of certain racemic nitriles to the corresponding R- or S-amides. Also provided are transformed microorganisms capable of the active expression of said nitrile hydratase activity. Additionally, the invention provides a transformant harboring the nitrile hydratase gene in conjunction with an amidase gene, both of which may be co-expressed producing active nitrile hydratase and amidase enzymes respectively. Methods for the production of such enantiomeric materials are also provided.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: September 22, 1998
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert Donald Fallon, Mark James Nelson, Mark Scott Payne