Abstract: Provided herein are methods of identifying genomic region(s) predictive of an outcome of treatment with a cell therapy and/or of a phenotype of function of the cells. In some embodiments, the methods include epigenetic and/or epigenomic analyses of the cells in connection with methods for preparing engineered cells for cell therapy and/or predicting response to a cell therapy, e.g., engineered cells for cell therapy. In some embodiments, the methods include steps to assess, characterize and analyze changes or modifications in an epigenetic property of gene region or regions, such as chromatin accessibility, nucleosome occupancy, histone modification, spatial chromosomal conformation, transcription factor occupancy and/or DNA methylation. In some embodiments, the epigenetic and/or epigenomic analysis includes determining the epigenetic properties of a cell, e.g., an engineered cell for cell therapy.

Abstract: An interface for positive pressure respiratory therapy includes a mask assembly having a mask seal and a mask shell. The mask assembly is positioned lower than and exposes a bridge of the user's nose. The mask seal includes first and second portions on respective first and second sides of a nasal region that contact opposing sides of the user's nose. The first and second portions each include supports that help maintain a shape of the mask seal. A pair of covers can be supported relative to the mask assembly and adjacent a respective one of the first and second portions of the mask seal. The covers limit expansion of the first and second portions of the mask seal in response to pressurized air within the mask seal. The supports of the first and second portions can transfer load from the mask seal to the covers.

Abstract: The invention concerns a process to convert di-rhamnolipid to mono-rhamnolipid, using an ?-L-rhamnosidase enzyme which has a sequence identity of at least 70% with either SEQ ID. 1 or SEQ. ID 2.

Abstract: The invention concerns a process to convert di-rhamnolipid to mono-rhamnolipid comprising the following process steps: —(a) contact of a starting di-rhamnolipid material with an ?-L-rhamnosidase enzyme which is immobilised on a support; (b) separation of the produced mono-rhamnolipid from the reaction medium and/or side products; wherein the ?-L-rhamnosidase enzyme does not have ?-D-glucosidase activity.

Abstract: A secure data fabric (SDF) can include a security platform for sharing data, access and discovery of data, and audit traceability, across disparate data stores and networks. A SDF can leverage blockchain with attribute-based access control (ABAC). A SDF platform can include an immutable data storage medium, a data sharing node, a central processing unit, and memory having software, which can be configured to implement a blockchain and an ABAC module. The immutable data storage medium can be part of a network. The immutable data storage medium can be immutable off-chain data storage for the SDF, and a multi-layered ABAC security policy can be implemented for the SDF. The SDF can have a cross-domain topology model. A multi-party workflow for account keys and digital signatures management can be further implemented. A microservices-based access control module can be configured to dynamically evaluate digital security policies for a secure data fabric.

Abstract: A mining method (10) by which graphitic ore is produced in a form that constitutes an appropriate feedstock for an electrolytic process (20) for the production of graphitic materials through exfoliation. The graphitic ore feedstock may be utilised directly as an electrode in the electrolytic process (20). Also disclosed is a graphitic feedstock for an electrolytic process for the production of graphitic material through exfoliation of that feedstock, wherein the feedstock is less than about 99% graphite (w/w) and of a sufficiently cohesive and conductive nature as to allow electrochemical exfoliation therethroughout without fracturing that might result in collapse of a significant portion of the feedstock or that may result in a loss of conductivity throughout a significant portion of the feedstock.

Abstract: A mining method (10) by which graphitic ore is produced in a form that constitutes an appropriate feedstock for an electrolytic process (20) for the production of graphitic materials through exfoliation. The graphitic ore feedstock may be utilised directly as an electrode in the electrolytic process (20). Also disclosed is a graphitic feedstock for an electrolytic process for the production of graphitic material through exfoliation of that feedstock, wherein the feedstock is less than about 99% graphite (w/w) and of a sufficiently cohesive and conductive nature as to allow electrochemical exfoliation therethroughout without fracturing that might result in collapse of a significant portion of the feedstock or that may result in a loss of conductivity throughout a significant portion of the feedstock.