Patents by Inventor Mark Jason Hughes

Mark Jason Hughes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 6-?,9-?-difluoro-17-?-((2-furanylcarbonyl)oxy)-11-?-hydroxy-16-?-methy1-3-oxo-androsta-1,4-diene-17-?- -carbothioic acid S-fluoromethyl
    Patent number: 8309713
    Abstract: A novel process for preparing a compound of formula (I) which comprises converting a compound of formula (II) to a compound of formula (I) via a compound of formula (III), or a salt thereof, without isolating any intermediates.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: November 13, 2012
    Assignee: Glaxo Group Limited
    Inventors: Malcolm Brian Berry, Mark Jason Hughes, David Parry-Jones, Stephen John Skittrall
  • Process for the Preparation of 6-alpha,9-alpha-difluoro-17-alpha-((2-furanylcarbonyl)oxy)-11-beta-hydroxy-16-alpha-methyl-3-oxo-androsta-1,4-diene-17-beta- -carbothioic acid S-fluoromethyl
    Publication number: 20090118495
    Abstract: A novel process for preparing a compound of formula (I) which comprises converting a compound of formula (II) to a compound of formula (I) via a compound of formula (III), or a salt thereof, without isolating any intermediates.
    Type: Application
    Filed: June 13, 2007
    Publication date: May 7, 2009
    Applicant: GLAXO GROUP LIMITED
    Inventors: Malcolm Brian Berry, Mark Jason Hughes, David Parry-Jones, Stephen John Skittrall
  • Novel processes for the preparation of 4-phenylpiperidine derivatives
    Publication number: 20040087795
    Abstract: A process for preparing compound (E) from compound (A), with or without isolation of intermediate products, characterised by one or more of the following steps:
    Type: Application
    Filed: June 24, 2003
    Publication date: May 6, 2004
    Inventors: Gary Thomas Borrett, Michael Fedouloff, Mark Jason Hughes, Andrew Colin Share, John Bryce Strachan, Peter Szeto, Martyn Voyle
  • Nitrosation process
    Patent number: 6596869
    Abstract: A process for preparing compounds of formula (I), by nitrosating compounds of formula (II), compounds of formula (I) having pharmaceutical activity.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: July 22, 2003
    Assignee: SmithKline Beecham plc
    Inventors: Mark Jason Hughes, John Kitteringham
  • Nitrosation process
    Publication number: 20020143185
    Abstract: 1
    Type: Application
    Filed: May 30, 2002
    Publication date: October 3, 2002
    Inventors: Mark Jason Hughes, John Kitteringham
  • Novel process
    Publication number: 20020010155
    Abstract: A process for the preparation of a 4-aryl-3-oxymethyl-piperidine of structure (1) 1
    Type: Application
    Filed: August 3, 2001
    Publication date: January 24, 2002
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Mark Jason Hughes, John Kitteringham, Victor Witold Jacewicz, Gillian Elizabeth Smith, Martyn Voyle, Evgeny Shapiro
  • Process for the preparation of azabicyclic derivatives
    Patent number: 5808075
    Abstract: A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R.sub.1 represents (a) in which r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1; R.sub.2 is a group OR.sub.4, where R.sub.4 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl or a group OCOR.sub.5 where R.sub.5 is hydrogen or R.sub.4 ; and R.sub.3 is CN; said process comprising reacting a compound of formula (II) wherein R.sub.1 ' is R.sub.1 or a group convertible thereto, and R.sub.3 ' is an electron withdrawing group, with a source of nitrous acid, and thereafter converting the resulting .dbd.NOH group to .dbd.NR.sub.2 wherein R.sub.2 is as defined in formula (I), converting R.sub.1 ' and R.sub.3 ' when other than R.sub.1 and R.sub.3 to R.sub.1 and R.sub.3, and thereafter optionally forming a pharmaceutically acceptable salt.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: September 15, 1998
    Inventors: Steven Mark Bromidge, Martyn Voyle, Erol Ali Faruk, Mark Jason Hughes, John Kitteringham, Gary Thomas Borrett
  • Process for the preparation of azabicycloc derivatives
    Patent number: 5773619
    Abstract: A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sub.1 represents ##STR2## in which r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1;R.sub.2 is a group OR.sub.4, where R.sub.4 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl or a group OCOR.sub.5 where R.sub.5 is hydrogen or R.sub.4 ; andR.sub.3 is CN;said process comprising reacting a compound of formula (II): ##STR3## wherein R.sub.1 ' is R.sub.1 or a group convertible thereto, and R.sub.3 ' is an electron withdrawing group, with a source of nitrous acid, and thereafter converting the resulting .dbd.NOH group to .dbd.NR.sub.2 wherein R.sub.2 is as defined in formula (I), converting R.sub.1 ' and R.sub.3 ' when other than R.sub.1 and R.sub.3 to R.sub.1 and R.sub.3, and thereafter optionally forming a pharmaceutically acceptable salt.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: June 30, 1998
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Steven Mark Bromidge, Martyn Voyle, Erol Ali Faruk, Mark Jason Hughes, John Kitteringham, Gary Thomas Borrett
  • Derivatives of quinuclidine n-oxide as muscarinic receptor ligands
    Patent number: 5675007
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof (I) wherein R.sub.1 represents (a), R.sub.2 is a group OCH.sub.3, and R.sub.3 is cyano, for use in the treatment and/or prophylaxis of dementia in mammals.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: October 7, 1997
    Assignee: SmithKline Beecham p.l.c.
    Inventors: John Keogh, Gary Thomas Borrett, Steven Mark Bromidge, Erol Ali Faruk, Mark Jason Hughes, John Kitteringham, Martyn Voyle