Patents by Inventor Mark Jay Hoser

Mark Jay Hoser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isothermal nucleic acid amplification
    Patent number: 10472659
    Abstract: The present disclosure relates to methods and compositions for ATP regeneration system for use in conjunction with the strand invasion step of an isothermal nucleic acid amplification which uses recombinases that utilize ATP as an energy source.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: November 12, 2019
    Assignee: GENEFORM TECHNOLOGIES LIMITED
    Inventor: Mark Jay Hoser
  • ISOTHERMAL NUCLEIC ACID AMPLIFICATION
    Publication number: 20170298401
    Abstract: An isothermal process for amplifying a nucleic acid target molecule that relies on an upstream primer, a downstream primer, a strand invasion system and an oligonucleotide, wherein the upstream and downstream primers are not substrates for the strand invasion system during the amplification process and do not amplify the target molecule independently of the strand invasion system, wherein the oligonucleotide is a substrate for the strand invasion system.
    Type: Application
    Filed: April 12, 2017
    Publication date: October 19, 2017
    Inventor: Mark Jay HOSER
  • Isothermal nucleic acid amplification
    Patent number: 9657340
    Abstract: A kit for performing isothermal amplification of a nucleic acid target molecule, where the amplification relies on an upstream primer, a downstream primer, a strand invasion system and an oligonucleotide, wherein the upstream and downstream primers are not substrates for the strand invasion system during the amplification process and do not amplify the target molecule independently of the strand invasion system, wherein the oligonucleotide is a substrate for the strand invasion system.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: May 23, 2017
    Assignee: ORION PHARMA (UK) LIMITED
    Inventor: Mark Jay Hoser
  • ISOTHERMAL NUCLEIC ACID AMPLIFICATION
    Publication number: 20150307928
    Abstract: A kit for performing isothermal amplification of a nucleic acid target molecule, where the amplification relies on an upstream primer, a downstream primer, a strand invasion system and an oligonucleotide, wherein the upstream and downstream primers are not substrates for the strand invasion system during the amplification process and do not amplify the target molecule independently of the strand invasion system, wherein the oligonucleotide is a substrate for the strand invasion system.
    Type: Application
    Filed: May 12, 2015
    Publication date: October 29, 2015
    Inventor: Mark Jay HOSER
  • Isothermal nucleic acid amplification
    Patent number: 9062344
    Abstract: The disclosure relates to an isothermal process for amplifying a double-stranded nucleic acid target molecule. The process comprises providing an upstream primer, a downstream primer, a strand invasion system and an oligonucleotide. The upstream and downstream primers are not substrates for the strand invasion system during the amplification process and do not amplify the target molecule independently of the strand invasion system, and the oligonucleotide is a substrate for the strand invasion system.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: June 23, 2015
    Assignee: GENEFORM TECHNOLOGIES LIMITED
    Inventor: Mark Jay Hoser
  • ISOTHERMAL NUCLEIC ACID AMPLIFICATION
    Publication number: 20110123991
    Abstract: An isothermal process for amplifying a nucleic acid target molecule that relies on an upstream primer, a downstream primer, a strand invasion system and an oligonucleotide, wherein the upstream and downstream primers are not substrates for the strand invasion system during the amplification process and do not amplify the target molecule independently of the strand invasion system, wherein the oligonucleotide is a substrate for the strand invasion system.
    Type: Application
    Filed: June 11, 2009
    Publication date: May 26, 2011
    Inventor: Mark Jay Hoser
  • Isothermal amplification of nucleic acids
    Patent number: 7824890
    Abstract: A process of amplifying a nucleic acid template dependent on partial destruction of primer molecules which have extended onto the template molecule followed by strand invasion of the partially destroyed primer template by a replacement primer. The destruction of the primer molecule may be performed by either endonuclease or exonuclease digestion. A signal generation from the amplified products may be obtained by the use of adaptors capable of binding probe molecules as well as the amplified product.
    Type: Grant
    Filed: February 17, 2006
    Date of Patent: November 2, 2010
    Assignee: Avacta Group PLC
    Inventors: Mark Jay Hoser, Christian Kurtis
  • Isothermal Amplification of Nucleic Acids
    Publication number: 20080286835
    Abstract: A process of amplifying a nucleic acid template dependent on partial destruction of primer molecules which have extended onto the template molecule followed by strand invasion of the partially destroyed primer template by a replacement primer. The destruction of the primer molecule may be performed by either endonuclease or exonuclease digestion. A signal generation from the amplified products may be obtained by the use of adaptors capable of binding probe molecules as well as the amplified product.
    Type: Application
    Filed: February 17, 2006
    Publication date: November 20, 2008
    Applicant: GeneForm Technologies Limited
    Inventors: Mark Jay Hoser, Christian Kurtis