Patents by Inventor Mark Jeffery Jaroszeski

Mark Jeffery Jaroszeski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted delivery of molecules using impedance-based monitoring at elevated temperatures
    Patent number: 11123554
    Abstract: A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature. The method may be used to deliver a molecule such as a vaccine or therapeutic to a biological structure, such as for prevention or treatment of SARS-CoV-2 infection.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: September 21, 2021
    Assignees: University of South Florida, Old Dominion University
    Inventors: Richard Heller, Loree C. Heller, Mark Jeffery Jaroszeski
  • Targeted delivery of molecules using impedence-based monitoring at elevated temperatures
    Patent number: 10974045
    Abstract: A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: April 13, 2021
    Assignees: University of South Florida, Old Dominion University
    Inventors: Mark Jeffery Jaroszeski, Richard Heller
  • TARGETED DELIVERY OF MOLECULES USING IMPEDENCE-BASED MONITORING AT ELEVATED TEMPERATURES
    Publication number: 20210101003
    Abstract: A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature. The method may be used to deliver a molecule such as a vaccine or therapeutic to a biological structure, such as for prevention or treatment of SARS-CoV-2 infection.
    Type: Application
    Filed: November 25, 2020
    Publication date: April 8, 2021
    Inventors: Richard Heller, Loree C. Heller, Mark Jeffery Jaroszeski
  • Targeted delivery of molecules using impedance-based monitoring at elevated temperatures
    Patent number: 10814129
    Abstract: A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: October 27, 2020
    Assignees: University of South Florida, Old Dominion University
    Inventors: Mark Jeffery Jaroszeski, Richard Heller