Patents by Inventor Mark Jeffrey Jaroszeski

Mark Jeffrey Jaroszeski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ELECTROTRANSFER METHODS FOR TREATING TUMORS
    Publication number: 20240075145
    Abstract: Disclosed herein are electrotransfer (ET) methods for delivering therapeutic agents to tumors. Also disclosed are methods of using the ET methods for differential delivery of an agent to more than one tissue. For example, the ET methods can be used to deliver soluble peptides of PD1 to tumor tissue to block normal PD1-PDL1 binding while separately using the ET methods to deliver PD1 or PDL1 antigen to another tissue, such as skin or muscle, to induce systemic and polyclonal checkpoint inhibitor antibodies.
    Type: Application
    Filed: January 24, 2022
    Publication date: March 7, 2024
    Inventors: Loree C. HELLER, Richard HELLER, Mark Jeffrey JAROSZESKI
  • Method for electroporation controlled by electrical impedence measurements
    Patent number: 11911611
    Abstract: The present invention provides a system and method for measuring an impedance of one or more target cells before and after an electroporation protocol has been applied to the one or more target cells. The result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize the electrical treatment for a particular target cell or cellular tissue.
    Type: Grant
    Filed: May 2, 2022
    Date of Patent: February 27, 2024
    Assignee: University of South Florida
    Inventors: Mark Jeffrey Jaroszeski, Timothy Fawcett, Richard Jason Connolly, Andrew M. Hoff, Reginald Morley Atkins, Douglas Walter Brown, Richard A. Gilbert
  • METHOD FOR ELECTROPORATION CONTROLLED BY ELECTRICAL IMPEDENCE MEASUREMENTS
    Publication number: 20220266006
    Abstract: The present invention provides a system and method for measuring the impedance of one more target cells before and after an electroporation protocol has been applied to the cells. The result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize the electrical treatment for a particular target cell or cellular tissue.
    Type: Application
    Filed: May 2, 2022
    Publication date: August 25, 2022
    Inventors: Mark Jeffrey Jaroszeski, Timothy Fawcett, Richard Jason Connolly, Andrew M. Hoff, Reginald Morley Atkins, Douglas Walter Brown, Richard A. Gilbert
  • System and method for electroporation controlled by electrical impedance measurements
    Patent number: 11318304
    Abstract: The present invention provides a system and a method for measuring an impedance of one or more target cells before and after an electroporation protocol has been applied to the one or more target cells. A result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize an electrical treatment for a particular target cell or cellular tissue.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: May 3, 2022
    Assignee: University of South Florida
    Inventors: Mark Jeffrey Jaroszeski, Timothy Fawcett, Richard Jason Connolly, Andrew M. Hoff, Reginald Morley Atkins, Douglas Walter Brown, Richard A. Gilbert