Abstract: A cartridge for administration of a bioactive agent may include a plurality of chambers, including at least a first chamber and a second chamber. Each of the chambers may contain a component of a composition to be administered to a tissue site of a subject. For example, the first chamber may contain the bioactive agent and the second chamber may contain a liquid for suspending the bioactive agent prior to administration to the tissue site. An apparatus for administering or delivering a bioactive agent may include the cartridge and may further include an energy source for providing an electrical pulse to the tissue site. The apparatus may further cause mixing of the bioactive agent with the liquid in the cartridge. For example, the apparatus may impact the cartridge to result in mixing of the bioactive agent with the liquid. A method for combining a bioactive agent with a liquid forms a composition for delivering to a tissue site.